PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2
Cardiomyocyte maturation and the acquisition of phenotypes is poorly understood at the single cell level. Here, the authors analyse the transcriptome of single cells from neonatal to adult heart and reveal that peroxisome proliferator-activated receptor coactivator-1 mediates the phenotypic shift.
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21957-z |
| _version_ | 1818684134474645504 |
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| author | Sean A. Murphy Matthew Miyamoto Anaïs Kervadec Suraj Kannan Emmanouil Tampakakis Sandeep Kambhampati Brian Leei Lin Sam Paek Peter Andersen Dong-Ik Lee Renjun Zhu Steven S. An David A. Kass Hideki Uosaki Alexandre R. Colas Chulan Kwon |
| author_facet | Sean A. Murphy Matthew Miyamoto Anaïs Kervadec Suraj Kannan Emmanouil Tampakakis Sandeep Kambhampati Brian Leei Lin Sam Paek Peter Andersen Dong-Ik Lee Renjun Zhu Steven S. An David A. Kass Hideki Uosaki Alexandre R. Colas Chulan Kwon |
| author_sort | Sean A. Murphy |
| collection | DOAJ |
| description | Cardiomyocyte maturation and the acquisition of phenotypes is poorly understood at the single cell level. Here, the authors analyse the transcriptome of single cells from neonatal to adult heart and reveal that peroxisome proliferator-activated receptor coactivator-1 mediates the phenotypic shift. |
| first_indexed | 2024-12-17T10:45:48Z |
| format | Article |
| id | doaj.art-e529861439104233888f042c1cc8bff3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:45:48Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e529861439104233888f042c1cc8bff32022-12-21T21:52:07ZengNature PortfolioNature Communications2041-17232021-03-0112111210.1038/s41467-021-21957-zPGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2Sean A. Murphy0Matthew Miyamoto1Anaïs Kervadec2Suraj Kannan3Emmanouil Tampakakis4Sandeep Kambhampati5Brian Leei Lin6Sam Paek7Peter Andersen8Dong-Ik Lee9Renjun Zhu10Steven S. An11David A. Kass12Hideki Uosaki13Alexandre R. Colas14Chulan Kwon15Division of Cardiology, Department of Medicine, Johns Hopkins University School of MedicineDivision of Cardiology, Department of Medicine, Johns Hopkins University School of MedicineSanford Burnham Prebys Medical Discovery InstituteDivision of Cardiology, Department of Medicine, Johns Hopkins University School of MedicineDivision of Cardiology, Department of Medicine, Johns Hopkins University School of MedicineDivision of Cardiology, Department of Medicine, Johns Hopkins University School of MedicineDivision of Cardiology, Department of Medicine, Johns Hopkins University School of MedicineRutgers Institute for Translational Medicine and ScienceDivision of Cardiology, Department of Medicine, Johns Hopkins University School of MedicineDivision of Cardiology, Department of Medicine, Johns Hopkins University School of MedicineDivision of Cardiology, Department of Medicine, Johns Hopkins University School of MedicineRutgers Institute for Translational Medicine and ScienceDivision of Cardiology, Department of Medicine, Johns Hopkins University School of MedicineDivision of Cardiology, Department of Medicine, Johns Hopkins University School of MedicineSanford Burnham Prebys Medical Discovery InstituteDivision of Cardiology, Department of Medicine, Johns Hopkins University School of MedicineCardiomyocyte maturation and the acquisition of phenotypes is poorly understood at the single cell level. Here, the authors analyse the transcriptome of single cells from neonatal to adult heart and reveal that peroxisome proliferator-activated receptor coactivator-1 mediates the phenotypic shift.https://doi.org/10.1038/s41467-021-21957-z |
| spellingShingle | Sean A. Murphy Matthew Miyamoto Anaïs Kervadec Suraj Kannan Emmanouil Tampakakis Sandeep Kambhampati Brian Leei Lin Sam Paek Peter Andersen Dong-Ik Lee Renjun Zhu Steven S. An David A. Kass Hideki Uosaki Alexandre R. Colas Chulan Kwon PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2 Nature Communications |
| title | PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2 |
| title_full | PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2 |
| title_fullStr | PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2 |
| title_full_unstemmed | PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2 |
| title_short | PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2 |
| title_sort | pgc1 ppar drive cardiomyocyte maturation at single cell level via yap1 and sf3b2 |
| url | https://doi.org/10.1038/s41467-021-21957-z |
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