Normative Data and Determinants of Macular, Disc, and Peripapillary Vascular Density in Healthy Myopic Children Using Optical Coherence Tomography Angiography
ObjectiveTo establish a normative database for the vascular density (VD) in macular, disc, and peripapillary regions in healthy myopic children and to evaluate associated ocular features with optical coherence tomography angiography (OCTA).MethodsThis was an observational, prospective and cross-sect...
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Frontiers Media S.A.
2022-06-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.890294/full |
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| author | Ruru Chen Hengli Lian Colm McAlinden Colm McAlinden Colm McAlinden Colm McAlinden Eirini Skiadaresi Siyu Liu Ting Wan Kai Diao Hongxian Pan Jia Qu Jinhai Huang Jinhai Huang Jinhai Huang Yiyu Li |
| author_facet | Ruru Chen Hengli Lian Colm McAlinden Colm McAlinden Colm McAlinden Colm McAlinden Eirini Skiadaresi Siyu Liu Ting Wan Kai Diao Hongxian Pan Jia Qu Jinhai Huang Jinhai Huang Jinhai Huang Yiyu Li |
| author_sort | Ruru Chen |
| collection | DOAJ |
| description | ObjectiveTo establish a normative database for the vascular density (VD) in macular, disc, and peripapillary regions in healthy myopic children and to evaluate associated ocular features with optical coherence tomography angiography (OCTA).MethodsThis was an observational, prospective and cross-sectional study. 776 Chinese healthy myopic children (375 boys and 401 girls) were enrolled, mean (±SD) age 9.84 ± 1.98 (range 6–16) years. En-face angiogram OCTA was performed on 6 mm × 6 mm retinal and 4.5 mm × 4.5 mm disc regions. VD measurements in the macular retina were segmented into the four regions: superficial capillary plexus (SCP), intermediate capillary plexus (ICP), deep capillary plexus (DCP), and choriocapillaris (CC). Correlations between macular, disc, and peripapillary VD and possible influencing factors [age, gender, axial length (AL), spherical equivalent refraction (SER), right/left eye, and signal strength index (SSI)] were assessed by Pearson’s correlation and multivariate regression analysis.ResultsFor macular scans, the corrected VD in the ICP region was (48.25 ± 4.24)% for the whole macular retina. The macular ICP VD in most sections was lower than the SCP, DCP, and CC (all P < 0.001). The corrected VD in CC was (72.96 ± 4.42)% for the whole macular retina. The macular CC VD in every section was all higher than the SCP, ICP, and DCP (all P < 0.001). The size of foveal avascular zone (FAZ) and foveal VD 300 (FD-300) was 0.28 mm2± 0.10 mm2 and (58.43 ± 4.17)% respectively. For disc scans, the corrected VD was (58.04 ± 2.73)% for the whole disc area. Both AL and SER were strongly correlated with ICP, DCP, and CC VD in all regions (all P < 0.01). Larger SSI was correlated with a lower VD in the SCP and ICP, and a higher VD in DCP and CC (all P < 0.01).ConclusionVascular density values provide large scale normative data on macular, disc, and peripapillary vascular parameters in a large sample of healthy myopic children with OCTA measured in the four different retinal plexuses and regions. The VD in different regions had various influencing factors; mainly a close correlation with AL and SSI. |
| first_indexed | 2024-12-12T16:41:24Z |
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| last_indexed | 2024-12-12T16:41:24Z |
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| spelling | doaj.art-e52b25c3d0244d42b7584954b1466d542022-12-22T00:18:34ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-06-01910.3389/fmed.2022.890294890294Normative Data and Determinants of Macular, Disc, and Peripapillary Vascular Density in Healthy Myopic Children Using Optical Coherence Tomography AngiographyRuru Chen0Hengli Lian1Colm McAlinden2Colm McAlinden3Colm McAlinden4Colm McAlinden5Eirini Skiadaresi6Siyu Liu7Ting Wan8Kai Diao9Hongxian Pan10Jia Qu11Jinhai Huang12Jinhai Huang13Jinhai Huang14Yiyu Li15Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, ChinaEye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, ChinaEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, ChinaNHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, ChinaDepartment of Ophthalmology, Singleton Hospital, Swansea Bay University Health Board, Swansea, United KingdomDepartment of Ophthalmology, Royal Gwent Hospital, Aneurin Bevan University Health Board, Newport, United KingdomDepartment of Ophthalmology, Prince Philip Hospital, Hywel Dda University Health Board, Llanelli, United KingdomEye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, ChinaEye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, ChinaEye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, ChinaEye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, ChinaEye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, ChinaEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, ChinaNHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, ChinaShanghai Research Center of Ophthalmology and Optometry, Shanghai, ChinaEye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, ChinaObjectiveTo establish a normative database for the vascular density (VD) in macular, disc, and peripapillary regions in healthy myopic children and to evaluate associated ocular features with optical coherence tomography angiography (OCTA).MethodsThis was an observational, prospective and cross-sectional study. 776 Chinese healthy myopic children (375 boys and 401 girls) were enrolled, mean (±SD) age 9.84 ± 1.98 (range 6–16) years. En-face angiogram OCTA was performed on 6 mm × 6 mm retinal and 4.5 mm × 4.5 mm disc regions. VD measurements in the macular retina were segmented into the four regions: superficial capillary plexus (SCP), intermediate capillary plexus (ICP), deep capillary plexus (DCP), and choriocapillaris (CC). Correlations between macular, disc, and peripapillary VD and possible influencing factors [age, gender, axial length (AL), spherical equivalent refraction (SER), right/left eye, and signal strength index (SSI)] were assessed by Pearson’s correlation and multivariate regression analysis.ResultsFor macular scans, the corrected VD in the ICP region was (48.25 ± 4.24)% for the whole macular retina. The macular ICP VD in most sections was lower than the SCP, DCP, and CC (all P < 0.001). The corrected VD in CC was (72.96 ± 4.42)% for the whole macular retina. The macular CC VD in every section was all higher than the SCP, ICP, and DCP (all P < 0.001). The size of foveal avascular zone (FAZ) and foveal VD 300 (FD-300) was 0.28 mm2± 0.10 mm2 and (58.43 ± 4.17)% respectively. For disc scans, the corrected VD was (58.04 ± 2.73)% for the whole disc area. Both AL and SER were strongly correlated with ICP, DCP, and CC VD in all regions (all P < 0.01). Larger SSI was correlated with a lower VD in the SCP and ICP, and a higher VD in DCP and CC (all P < 0.01).ConclusionVascular density values provide large scale normative data on macular, disc, and peripapillary vascular parameters in a large sample of healthy myopic children with OCTA measured in the four different retinal plexuses and regions. The VD in different regions had various influencing factors; mainly a close correlation with AL and SSI.https://www.frontiersin.org/articles/10.3389/fmed.2022.890294/fullvascular density (VD)optical coherence tomography angiography (OCTA)maculardiscperipapillary |
| spellingShingle | Ruru Chen Hengli Lian Colm McAlinden Colm McAlinden Colm McAlinden Colm McAlinden Eirini Skiadaresi Siyu Liu Ting Wan Kai Diao Hongxian Pan Jia Qu Jinhai Huang Jinhai Huang Jinhai Huang Yiyu Li Normative Data and Determinants of Macular, Disc, and Peripapillary Vascular Density in Healthy Myopic Children Using Optical Coherence Tomography Angiography Frontiers in Medicine vascular density (VD) optical coherence tomography angiography (OCTA) macular disc peripapillary |
| title | Normative Data and Determinants of Macular, Disc, and Peripapillary Vascular Density in Healthy Myopic Children Using Optical Coherence Tomography Angiography |
| title_full | Normative Data and Determinants of Macular, Disc, and Peripapillary Vascular Density in Healthy Myopic Children Using Optical Coherence Tomography Angiography |
| title_fullStr | Normative Data and Determinants of Macular, Disc, and Peripapillary Vascular Density in Healthy Myopic Children Using Optical Coherence Tomography Angiography |
| title_full_unstemmed | Normative Data and Determinants of Macular, Disc, and Peripapillary Vascular Density in Healthy Myopic Children Using Optical Coherence Tomography Angiography |
| title_short | Normative Data and Determinants of Macular, Disc, and Peripapillary Vascular Density in Healthy Myopic Children Using Optical Coherence Tomography Angiography |
| title_sort | normative data and determinants of macular disc and peripapillary vascular density in healthy myopic children using optical coherence tomography angiography |
| topic | vascular density (VD) optical coherence tomography angiography (OCTA) macular disc peripapillary |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.890294/full |
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