Tracing the Origin of Cell-Free DNA Molecules through Tissue-Specific Epigenetic Signatures

Tracing the Origin of Cell-Free DNA Molecules through Tissue-Specific Epigenetic Signatures

All cell and tissue types constantly release DNA fragments into human body fluids by various mechanisms including programmed cell death, accidental cell degradation and active extrusion. Particularly, cell-free DNA (cfDNA) in plasma or serum has been utilized for minimally invasive molecular diagnos...

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Bibliographic Details
Main Authors: Angela Oberhofer, Abel J. Bronkhorst, Carsten Uhlig, Vida Ungerer, Stefan Holdenrieder
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Diagnostics
Subjects:
cell-free DNA
epigenetics
liquid biopsy
tissue-of-origin
Online Access:https://www.mdpi.com/2075-4418/12/8/1834

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