The comparison of preemptive effects of propofol, remifentanil and ketamine on post-operative pain scores and analgesic requirements in elective lower abdominal surgery under general anesthesia: A randomized, double-blinded study
Background: In this randomized, double-blinded study, we investigated the preemptive effects of propofol, remifentanil or ketamine on post-operative pain scores and analgesic requirements in elective lower abdominal surgeries under general anesthesia during the first 24 h of post-operative period. M...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Journal of Research in Medical Sciences |
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| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2013;volume=18;issue=7;spage=567;epage=572;aulast=Naghibi |
| _version_ | 1818611573525053440 |
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| author | Khosrou Naghibi Parviz Kashefi Amir Mohamad Abtahi |
| author_facet | Khosrou Naghibi Parviz Kashefi Amir Mohamad Abtahi |
| author_sort | Khosrou Naghibi |
| collection | DOAJ |
| description | Background: In this randomized, double-blinded study, we investigated the preemptive effects of propofol, remifentanil or ketamine on post-operative pain scores and analgesic requirements in elective lower abdominal surgeries under general anesthesia during the first 24 h of post-operative period. Materials and Methods: Seventy five patients, American Society of Anesthesiologists physical status I or II candidate for elective lower abdominal surgery under general anesthesia were randomized to three groups (25 each). According to their allocated group, patients received either propofol 0.25 mg/kg, remifentanil 0.25 mic/kg or ketamine 0.3 mg/kg as preemptive analgesia immediately after the induction of general anesthesia. Post-operative pain scores with a numerical rating scale (visual analogue scale 0-10) were assessed and analgesic requirements and side-effects were compared through analysis using the SPSS version 18 in the post-operative period; post-anesthesia care unit 2, 6, 12 and 24 h. Results: Patients′ demographics were similar in all groups. The pain scores were significantly lower in remifentanil group immediately after recovery and also at 2 and 6 h post-operatively, but it reversed at 12 and 24 h after recovery comparing with propofol and ketamine. However, the mean of administered morphine in the first 24 h was significantly lower in propofol group (18.97 6.6) comparing with remifentanil group (21.96 6.55) and ketamine group (24.26 5.84) (P value, 0.01). Conclusion: Prophylactic preemptive single dose of intravenous (IV) 0.25 mg/kg propofol significantly decreased post-operative analgesia requirements comparing with IV 0.3 mg/kg ketamine or 0.25 μg/kg remifentanil. |
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| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-16T15:32:29Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-e52db0f0ab32458896f17226c8662e062022-12-21T22:26:18ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362013-01-01187567572The comparison of preemptive effects of propofol, remifentanil and ketamine on post-operative pain scores and analgesic requirements in elective lower abdominal surgery under general anesthesia: A randomized, double-blinded studyKhosrou NaghibiParviz KashefiAmir Mohamad AbtahiBackground: In this randomized, double-blinded study, we investigated the preemptive effects of propofol, remifentanil or ketamine on post-operative pain scores and analgesic requirements in elective lower abdominal surgeries under general anesthesia during the first 24 h of post-operative period. Materials and Methods: Seventy five patients, American Society of Anesthesiologists physical status I or II candidate for elective lower abdominal surgery under general anesthesia were randomized to three groups (25 each). According to their allocated group, patients received either propofol 0.25 mg/kg, remifentanil 0.25 mic/kg or ketamine 0.3 mg/kg as preemptive analgesia immediately after the induction of general anesthesia. Post-operative pain scores with a numerical rating scale (visual analogue scale 0-10) were assessed and analgesic requirements and side-effects were compared through analysis using the SPSS version 18 in the post-operative period; post-anesthesia care unit 2, 6, 12 and 24 h. Results: Patients′ demographics were similar in all groups. The pain scores were significantly lower in remifentanil group immediately after recovery and also at 2 and 6 h post-operatively, but it reversed at 12 and 24 h after recovery comparing with propofol and ketamine. However, the mean of administered morphine in the first 24 h was significantly lower in propofol group (18.97 6.6) comparing with remifentanil group (21.96 6.55) and ketamine group (24.26 5.84) (P value, 0.01). Conclusion: Prophylactic preemptive single dose of intravenous (IV) 0.25 mg/kg propofol significantly decreased post-operative analgesia requirements comparing with IV 0.3 mg/kg ketamine or 0.25 μg/kg remifentanil.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2013;volume=18;issue=7;spage=567;epage=572;aulast=NaghibiAnalgesic requirementketaminepost-operative pain scorepreemptive analgesiapropofolremifentanil |
| spellingShingle | Khosrou Naghibi Parviz Kashefi Amir Mohamad Abtahi The comparison of preemptive effects of propofol, remifentanil and ketamine on post-operative pain scores and analgesic requirements in elective lower abdominal surgery under general anesthesia: A randomized, double-blinded study Journal of Research in Medical Sciences Analgesic requirement ketamine post-operative pain score preemptive analgesia propofol remifentanil |
| title | The comparison of preemptive effects of propofol, remifentanil and ketamine on post-operative pain scores and analgesic requirements in elective lower abdominal surgery under general anesthesia: A randomized, double-blinded study |
| title_full | The comparison of preemptive effects of propofol, remifentanil and ketamine on post-operative pain scores and analgesic requirements in elective lower abdominal surgery under general anesthesia: A randomized, double-blinded study |
| title_fullStr | The comparison of preemptive effects of propofol, remifentanil and ketamine on post-operative pain scores and analgesic requirements in elective lower abdominal surgery under general anesthesia: A randomized, double-blinded study |
| title_full_unstemmed | The comparison of preemptive effects of propofol, remifentanil and ketamine on post-operative pain scores and analgesic requirements in elective lower abdominal surgery under general anesthesia: A randomized, double-blinded study |
| title_short | The comparison of preemptive effects of propofol, remifentanil and ketamine on post-operative pain scores and analgesic requirements in elective lower abdominal surgery under general anesthesia: A randomized, double-blinded study |
| title_sort | comparison of preemptive effects of propofol remifentanil and ketamine on post operative pain scores and analgesic requirements in elective lower abdominal surgery under general anesthesia a randomized double blinded study |
| topic | Analgesic requirement ketamine post-operative pain score preemptive analgesia propofol remifentanil |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2013;volume=18;issue=7;spage=567;epage=572;aulast=Naghibi |
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