Biomolecule-functionalized nanoformulations for prostate cancer theranostics
Background: Even with the advancement in the areas of cancer nanotechnology, prostate cancer still poses a major threat to men’s health. Nanomaterials and nanomaterial-derived theranostic systems have been explored for diagnosis, imaging, and therapy for different types of cancer still, for prostate...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Journal of Advanced Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123222002508 |
| _version_ | 1797730011374944256 |
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| author | Pranav Partha Laskar Meena Jaggi Subhash C. Chauhan Murali M. Yallapu |
| author_facet | Pranav Partha Laskar Meena Jaggi Subhash C. Chauhan Murali M. Yallapu |
| author_sort | Pranav |
| collection | DOAJ |
| description | Background: Even with the advancement in the areas of cancer nanotechnology, prostate cancer still poses a major threat to men’s health. Nanomaterials and nanomaterial-derived theranostic systems have been explored for diagnosis, imaging, and therapy for different types of cancer still, for prostate cancer they have not delivered at full potential because of the limitations like in vivo biocompatibility, immune responses, precise targetability, and therapeutic outcome associated with the nanostructured system. Aim of review: Functionalizing nanomaterials with different biomolecules and bioactive agents provides advantages like specificity towards cancerous tumors, improved circulation time, and modulation of the immune response leading to early diagnosis and targeted delivery of cargo at the site of action. Key scientific concepts of review: In this review, we have emphasized the classification and comparison of various nanomaterials based on biofunctionalization strategy and source of biomolecules such that it can be used for possible translation in clinical settings and future developments. This review highlighted the opportunities for embedding highly specific biological targeting moieties (antibody, aptamer, oligonucleotides, biopolymer, peptides, etc.) on nanoparticles which can improve the detection of prostate cancer-associated biomarkers at a very low limit of detection, direct visualization of prostate tumors and lastly for its therapy. Lastly, special emphasis was given to biomimetic nanomaterials which include functionalization with extracellular vesicles, exosomes and viral particles and their application for prostate cancer early detection and drug delivery. The present review paves a new pathway for next-generation biofunctionalized nanomaterials for prostate cancer theranostic application and their possibility in clinical translation. |
| first_indexed | 2024-03-12T11:37:59Z |
| format | Article |
| id | doaj.art-e52db129437f4b59b37ab82d61cb668c |
| institution | Directory Open Access Journal |
| issn | 2090-1232 |
| language | English |
| last_indexed | 2024-03-12T11:37:59Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj.art-e52db129437f4b59b37ab82d61cb668c2023-09-01T05:01:03ZengElsevierJournal of Advanced Research2090-12322023-09-0151197217Biomolecule-functionalized nanoformulations for prostate cancer theranostics Pranav0Partha Laskar1Meena Jaggi2Subhash C. Chauhan3Murali M. Yallapu4Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USADepartment of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USADepartment of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USADepartment of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USACorresponding author at: Department of Immunology and Microbiology, Member, South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, Room 2.249, Biomedical Research Building, McAllen, TX 78504, USA.; Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USABackground: Even with the advancement in the areas of cancer nanotechnology, prostate cancer still poses a major threat to men’s health. Nanomaterials and nanomaterial-derived theranostic systems have been explored for diagnosis, imaging, and therapy for different types of cancer still, for prostate cancer they have not delivered at full potential because of the limitations like in vivo biocompatibility, immune responses, precise targetability, and therapeutic outcome associated with the nanostructured system. Aim of review: Functionalizing nanomaterials with different biomolecules and bioactive agents provides advantages like specificity towards cancerous tumors, improved circulation time, and modulation of the immune response leading to early diagnosis and targeted delivery of cargo at the site of action. Key scientific concepts of review: In this review, we have emphasized the classification and comparison of various nanomaterials based on biofunctionalization strategy and source of biomolecules such that it can be used for possible translation in clinical settings and future developments. This review highlighted the opportunities for embedding highly specific biological targeting moieties (antibody, aptamer, oligonucleotides, biopolymer, peptides, etc.) on nanoparticles which can improve the detection of prostate cancer-associated biomarkers at a very low limit of detection, direct visualization of prostate tumors and lastly for its therapy. Lastly, special emphasis was given to biomimetic nanomaterials which include functionalization with extracellular vesicles, exosomes and viral particles and their application for prostate cancer early detection and drug delivery. The present review paves a new pathway for next-generation biofunctionalized nanomaterials for prostate cancer theranostic application and their possibility in clinical translation.http://www.sciencedirect.com/science/article/pii/S2090123222002508Prostate cancerBiofunctionalizationProstate-specific diagnosisCombinational therapy |
| spellingShingle | Pranav Partha Laskar Meena Jaggi Subhash C. Chauhan Murali M. Yallapu Biomolecule-functionalized nanoformulations for prostate cancer theranostics Journal of Advanced Research Prostate cancer Biofunctionalization Prostate-specific diagnosis Combinational therapy |
| title | Biomolecule-functionalized nanoformulations for prostate cancer theranostics |
| title_full | Biomolecule-functionalized nanoformulations for prostate cancer theranostics |
| title_fullStr | Biomolecule-functionalized nanoformulations for prostate cancer theranostics |
| title_full_unstemmed | Biomolecule-functionalized nanoformulations for prostate cancer theranostics |
| title_short | Biomolecule-functionalized nanoformulations for prostate cancer theranostics |
| title_sort | biomolecule functionalized nanoformulations for prostate cancer theranostics |
| topic | Prostate cancer Biofunctionalization Prostate-specific diagnosis Combinational therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2090123222002508 |
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