Highlighting Hemodynamic Risks for Bioresorbable Stents in Coronary Arteries
A three-dimensional, transient computational fluid dynamics analysis was conducted on an idealised geometry of a coronary artery fitted with representative geometries of an Absorb bioresorbable vascular scaffold (BVS) or a Xience drug-eluting stent (DES) in order to identify and compare areas of dis...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Fluids |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2311-5521/8/9/241 |
| _version_ | 1797580115392069632 |
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| author | Marcus S. Elliott Jonathan S. Cole Ross W. Blair Gary H. Menary |
| author_facet | Marcus S. Elliott Jonathan S. Cole Ross W. Blair Gary H. Menary |
| author_sort | Marcus S. Elliott |
| collection | DOAJ |
| description | A three-dimensional, transient computational fluid dynamics analysis was conducted on an idealised geometry of a coronary artery fitted with representative geometries of an Absorb bioresorbable vascular scaffold (BVS) or a Xience drug-eluting stent (DES) in order to identify and compare areas of disturbed flow and potential risk sites. A non-Newtonian viscosity model was used with a transient velocity boundary condition programmed with user-defined functions. At-risk areas were quantified in terms of several parameters linked to restenosis: wall shear stress, time-averaged wall shear stress, oscillatory shear index, particle residence time, and shear rate. Results indicated that 71% of the BVS stented surface area had time-averaged wall shear stress values under 0.4 Pa compared to 45% of the DES area. Additionally, high particle residence times were present in 23% and 8% of the BVS and DES areas, respectively, with risk areas identified as being more prominent in close proximity to crowns and link struts. These results suggest an increased risk for thrombosis and neointimal hyperplasia for the BVS compared to the DES, which is in agreement with the outcomes of clinical trials. It is intended that the results of this study may be used as a pre-clinical tool to aid in the design of bioresorbable coronary stents. |
| first_indexed | 2024-03-10T22:46:45Z |
| format | Article |
| id | doaj.art-e5348ea583274aca9103552fba882c8b |
| institution | Directory Open Access Journal |
| issn | 2311-5521 |
| language | English |
| last_indexed | 2024-03-10T22:46:45Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Fluids |
| spelling | doaj.art-e5348ea583274aca9103552fba882c8b2023-11-19T10:41:15ZengMDPI AGFluids2311-55212023-08-018924110.3390/fluids8090241Highlighting Hemodynamic Risks for Bioresorbable Stents in Coronary ArteriesMarcus S. Elliott0Jonathan S. Cole1Ross W. Blair2Gary H. Menary3School of Mechanical and Aerospace Engineering, Queen’s University Belfast, Belfast BT7 1NN, UKSchool of Mechanical and Aerospace Engineering, Queen’s University Belfast, Belfast BT7 1NN, UKSchool of Mechanical and Aerospace Engineering, Queen’s University Belfast, Belfast BT7 1NN, UKSchool of Mechanical and Aerospace Engineering, Queen’s University Belfast, Belfast BT7 1NN, UKA three-dimensional, transient computational fluid dynamics analysis was conducted on an idealised geometry of a coronary artery fitted with representative geometries of an Absorb bioresorbable vascular scaffold (BVS) or a Xience drug-eluting stent (DES) in order to identify and compare areas of disturbed flow and potential risk sites. A non-Newtonian viscosity model was used with a transient velocity boundary condition programmed with user-defined functions. At-risk areas were quantified in terms of several parameters linked to restenosis: wall shear stress, time-averaged wall shear stress, oscillatory shear index, particle residence time, and shear rate. Results indicated that 71% of the BVS stented surface area had time-averaged wall shear stress values under 0.4 Pa compared to 45% of the DES area. Additionally, high particle residence times were present in 23% and 8% of the BVS and DES areas, respectively, with risk areas identified as being more prominent in close proximity to crowns and link struts. These results suggest an increased risk for thrombosis and neointimal hyperplasia for the BVS compared to the DES, which is in agreement with the outcomes of clinical trials. It is intended that the results of this study may be used as a pre-clinical tool to aid in the design of bioresorbable coronary stents.https://www.mdpi.com/2311-5521/8/9/241stentcoronary arterybioresorbable vascular scaffoldcomputational fluid dynamics |
| spellingShingle | Marcus S. Elliott Jonathan S. Cole Ross W. Blair Gary H. Menary Highlighting Hemodynamic Risks for Bioresorbable Stents in Coronary Arteries Fluids stent coronary artery bioresorbable vascular scaffold computational fluid dynamics |
| title | Highlighting Hemodynamic Risks for Bioresorbable Stents in Coronary Arteries |
| title_full | Highlighting Hemodynamic Risks for Bioresorbable Stents in Coronary Arteries |
| title_fullStr | Highlighting Hemodynamic Risks for Bioresorbable Stents in Coronary Arteries |
| title_full_unstemmed | Highlighting Hemodynamic Risks for Bioresorbable Stents in Coronary Arteries |
| title_short | Highlighting Hemodynamic Risks for Bioresorbable Stents in Coronary Arteries |
| title_sort | highlighting hemodynamic risks for bioresorbable stents in coronary arteries |
| topic | stent coronary artery bioresorbable vascular scaffold computational fluid dynamics |
| url | https://www.mdpi.com/2311-5521/8/9/241 |
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