Gold Nanoparticles for Vectorization of Nucleic Acids for Cancer Therapeutics
Cancer remains a complex medical challenge and one of the leading causes of death worldwide. Nanomedicines have been proposed as innovative platforms to tackle these complex diseases, where the combination of several treatment strategies might enhance therapy success. Among these nanomedicines, nano...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/15/3489 |
| _version_ | 1797560733630726144 |
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| author | Daniela Ferreira David Fontinha Catarina Martins David Pires Alexandra R. Fernandes Pedro V. Baptista |
| author_facet | Daniela Ferreira David Fontinha Catarina Martins David Pires Alexandra R. Fernandes Pedro V. Baptista |
| author_sort | Daniela Ferreira |
| collection | DOAJ |
| description | Cancer remains a complex medical challenge and one of the leading causes of death worldwide. Nanomedicines have been proposed as innovative platforms to tackle these complex diseases, where the combination of several treatment strategies might enhance therapy success. Among these nanomedicines, nanoparticle mediated delivery of nucleic acids has been put forward as key instrument to modulate gene expression, be it targeted gene silencing, interference RNA mechanisms and/or gene edition. These novel delivery systems have strongly relied on nanoparticles and, in particular, gold nanoparticles (AuNPs) have paved the way for efficient delivery systems due to the possibility to fine-tune their size, shape and surface properties, coupled to the ease of functionalization with different biomolecules. Herein, we shall address the different molecular tools for modulation of expression of oncogenes and tumor suppressor genes and discuss the state-of-the-art of AuNP functionalization for nucleic acid delivery both in vitro and in vivo models. Furthermore, we shall highlight the clinical applications of these spherical AuNP based conjugates for gene delivery, current challenges, and future perspectives in nanomedicine. |
| first_indexed | 2024-03-10T18:04:41Z |
| format | Article |
| id | doaj.art-e538cb31c737457f971e5e655087c704 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T18:04:41Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e538cb31c737457f971e5e655087c7042023-11-20T08:39:18ZengMDPI AGMolecules1420-30492020-07-012515348910.3390/molecules25153489Gold Nanoparticles for Vectorization of Nucleic Acids for Cancer TherapeuticsDaniela Ferreira0David Fontinha1Catarina Martins2David Pires3Alexandra R. Fernandes4Pedro V. Baptista5UCIBIO, Dept. of Life Sciences, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus de Caparica, 2829-516 Caparica, PortugalUCIBIO, Dept. of Life Sciences, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus de Caparica, 2829-516 Caparica, PortugalUCIBIO, Dept. of Life Sciences, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus de Caparica, 2829-516 Caparica, PortugalUCIBIO, Dept. of Life Sciences, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus de Caparica, 2829-516 Caparica, PortugalUCIBIO, Dept. of Life Sciences, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus de Caparica, 2829-516 Caparica, PortugalUCIBIO, Dept. of Life Sciences, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus de Caparica, 2829-516 Caparica, PortugalCancer remains a complex medical challenge and one of the leading causes of death worldwide. Nanomedicines have been proposed as innovative platforms to tackle these complex diseases, where the combination of several treatment strategies might enhance therapy success. Among these nanomedicines, nanoparticle mediated delivery of nucleic acids has been put forward as key instrument to modulate gene expression, be it targeted gene silencing, interference RNA mechanisms and/or gene edition. These novel delivery systems have strongly relied on nanoparticles and, in particular, gold nanoparticles (AuNPs) have paved the way for efficient delivery systems due to the possibility to fine-tune their size, shape and surface properties, coupled to the ease of functionalization with different biomolecules. Herein, we shall address the different molecular tools for modulation of expression of oncogenes and tumor suppressor genes and discuss the state-of-the-art of AuNP functionalization for nucleic acid delivery both in vitro and in vivo models. Furthermore, we shall highlight the clinical applications of these spherical AuNP based conjugates for gene delivery, current challenges, and future perspectives in nanomedicine.https://www.mdpi.com/1420-3049/25/15/3489gene editinggene silencinggold nanoparticlesnanomedicinetherapeutic nucleic acid |
| spellingShingle | Daniela Ferreira David Fontinha Catarina Martins David Pires Alexandra R. Fernandes Pedro V. Baptista Gold Nanoparticles for Vectorization of Nucleic Acids for Cancer Therapeutics Molecules gene editing gene silencing gold nanoparticles nanomedicine therapeutic nucleic acid |
| title | Gold Nanoparticles for Vectorization of Nucleic Acids for Cancer Therapeutics |
| title_full | Gold Nanoparticles for Vectorization of Nucleic Acids for Cancer Therapeutics |
| title_fullStr | Gold Nanoparticles for Vectorization of Nucleic Acids for Cancer Therapeutics |
| title_full_unstemmed | Gold Nanoparticles for Vectorization of Nucleic Acids for Cancer Therapeutics |
| title_short | Gold Nanoparticles for Vectorization of Nucleic Acids for Cancer Therapeutics |
| title_sort | gold nanoparticles for vectorization of nucleic acids for cancer therapeutics |
| topic | gene editing gene silencing gold nanoparticles nanomedicine therapeutic nucleic acid |
| url | https://www.mdpi.com/1420-3049/25/15/3489 |
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