Substituted N-Phenylpyrazine-2-carboxamides: Synthesis and Antimycobacterial Evaluation

Substituted N-Phenylpyrazine-2-carboxamides: Synthesis and Antimycobacterial Evaluation

The condensation of chlorides of substituted pyrazinecarboxylic acids with ringsubstituted anilines yielded twelve substituted pyrazinecarboxylic acid amides. The synthetic approach, analytical, and lipophilicity data of the newly synthesized compounds are presented. Two antituberculosis assays were...

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Bibliographic Details
Main Authors: Michaela Svobodová, Jiří Kuneš, Martin Doležal, Diana Kešetovičová, Jan Zitko
Format: Article
Language:English
Published: MDPI AG 2009-10-01
Series:Molecules
Subjects:
pyrazinecarboxamide synthesis
in vitro antimycobacterial screening
lipophilicity
SAR
Online Access:http://www.mdpi.com/1420-3049/14/10/4180/

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