Drugs associated with DIP
Drug-induced parkinsonism (DIP) is one of the most frequent extrapyramidal disorders that develops against the background of prescribing a large number of medications. Initially, DIP was described as an adverse drug reactions (ADRs) against the background of the use of antipsychotic drugs, but later...
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| Format: | Article |
| Sprog: | Russian |
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Remedium Group LLC
2021-12-01
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| Serier: | Медицинский совет |
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| Online adgang: | https://www.med-sovet.pro/jour/article/view/6539 |
| _version_ | 1827962029117276160 |
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| author | T. M. Ostroumova O. D. Ostroumova A. S. Soloveva |
| author_facet | T. M. Ostroumova O. D. Ostroumova A. S. Soloveva |
| author_sort | T. M. Ostroumova |
| collection | DOAJ |
| description | Drug-induced parkinsonism (DIP) is one of the most frequent extrapyramidal disorders that develops against the background of prescribing a large number of medications. Initially, DIP was described as an adverse drug reactions (ADRs) against the background of the use of antipsychotic drugs, but later recognized as ADRs of a number of other drugs, including prokinetics, antidepressants, calcium channel blockers and antiepileptic drugs. The relative risk of developing LIP on the background of taking typical antipsychotics increased by 2.92 times compared to patients who do not take these drugs. The risk of developing DIP in patients receiving flunarizine is increased by 2.75-4.07 times. The risk of DIP with the use of antidepressants is increased by 2.14 times, among the drugs of this group with an increased risk of DIP, the use of selective serotonin reuptake inhibitors is most often associated with DIP (relative risk 1.24). Among other antidepressants, there is evidence of the development of DIP against the background of the use of duloxetine, mirtazapine, amitriptyll clomipramine, venlafaxine, trazodone. Among anticonvulsants, DIP can rarely develop against the background of the appointment of valproic acid, gabapentin, pregabalin, carbamazepine, oxcarbazepine. The risk of DIP in patients receiving metoclopramide is extremely low (0.06%), but it is 2.16 times higher compared to people who do not take this drug. Among drugs from other groups, DIP can occur against the background of the use of lithium carbonate, tacrolimus, cyclosporine, amiodarone, captopril, amphotericin B. If DIP develops, it is necessary, if possible, to reduce the dose or cancel the inducer drug, or replace it with another drug with minimal risk of DIP. Symptoms of DIP most often regress within a few weeks or months after dose reduction or withdrawal of the drug inducer. If the symptoms persist longer, it is necessary to exclude the presence of Parkinson’s disease or dementia with with Lewy bodies. |
| first_indexed | 2024-04-09T16:36:29Z |
| format | Article |
| id | doaj.art-e53950c2a20a4e2c99b03e2e4079daa0 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:36:29Z |
| publishDate | 2021-12-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-e53950c2a20a4e2c99b03e2e4079daa02023-04-23T06:56:53ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902021-12-0101910911810.21518/2079-701X-2021-19-109-1185902Drugs associated with DIPT. M. Ostroumova0O. D. Ostroumova1A. S. Soloveva2Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University); Russian Medical Academy of Continuing Professional EducationSechenov First Moscow State Medical University (Sechenov University)Drug-induced parkinsonism (DIP) is one of the most frequent extrapyramidal disorders that develops against the background of prescribing a large number of medications. Initially, DIP was described as an adverse drug reactions (ADRs) against the background of the use of antipsychotic drugs, but later recognized as ADRs of a number of other drugs, including prokinetics, antidepressants, calcium channel blockers and antiepileptic drugs. The relative risk of developing LIP on the background of taking typical antipsychotics increased by 2.92 times compared to patients who do not take these drugs. The risk of developing DIP in patients receiving flunarizine is increased by 2.75-4.07 times. The risk of DIP with the use of antidepressants is increased by 2.14 times, among the drugs of this group with an increased risk of DIP, the use of selective serotonin reuptake inhibitors is most often associated with DIP (relative risk 1.24). Among other antidepressants, there is evidence of the development of DIP against the background of the use of duloxetine, mirtazapine, amitriptyll clomipramine, venlafaxine, trazodone. Among anticonvulsants, DIP can rarely develop against the background of the appointment of valproic acid, gabapentin, pregabalin, carbamazepine, oxcarbazepine. The risk of DIP in patients receiving metoclopramide is extremely low (0.06%), but it is 2.16 times higher compared to people who do not take this drug. Among drugs from other groups, DIP can occur against the background of the use of lithium carbonate, tacrolimus, cyclosporine, amiodarone, captopril, amphotericin B. If DIP develops, it is necessary, if possible, to reduce the dose or cancel the inducer drug, or replace it with another drug with minimal risk of DIP. Symptoms of DIP most often regress within a few weeks or months after dose reduction or withdrawal of the drug inducer. If the symptoms persist longer, it is necessary to exclude the presence of Parkinson’s disease or dementia with with Lewy bodies.https://www.med-sovet.pro/jour/article/view/6539parkinsonismdrug-induced parkinsonismmovement disordersdrugsadverse drug reactions |
| spellingShingle | T. M. Ostroumova O. D. Ostroumova A. S. Soloveva Drugs associated with DIP Медицинский совет parkinsonism drug-induced parkinsonism movement disorders drugs adverse drug reactions |
| title | Drugs associated with DIP |
| title_full | Drugs associated with DIP |
| title_fullStr | Drugs associated with DIP |
| title_full_unstemmed | Drugs associated with DIP |
| title_short | Drugs associated with DIP |
| title_sort | drugs associated with dip |
| topic | parkinsonism drug-induced parkinsonism movement disorders drugs adverse drug reactions |
| url | https://www.med-sovet.pro/jour/article/view/6539 |
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