<b>Testis evaluation of adult Wistar rats after neonatal treatment with fluoxetine</b> - doi: 10.4025/actascibiolsci.v35i1.10946
In current assay the serotoninergic system in newly-born Wistar rats underwent pharmacological modification by fluoxetine, a selective serotonin reuptake inhibitor (SSRI), to investigate its repercussion on testicular parameters in adult animals. Thirty animals were distributed according to treatmen...
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| Format: | Article |
| Language: | English |
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Universidade Estadual de Maringá
2012-08-01
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| Series: | Acta Scientiarum: Biological Sciences |
| Subjects: | |
| Online Access: | https://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/10946 |
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| author | Valdemiro Amaro da Silva Junior Waldo Oliveira Monteiro Filho Catarina Ferreira Pinto Sandra Maria de Torres Bruno Mendes Tenorio |
| author_facet | Valdemiro Amaro da Silva Junior Waldo Oliveira Monteiro Filho Catarina Ferreira Pinto Sandra Maria de Torres Bruno Mendes Tenorio |
| author_sort | Valdemiro Amaro da Silva Junior |
| collection | DOAJ |
| description | In current assay the serotoninergic system in newly-born Wistar rats underwent pharmacological modification by fluoxetine, a selective serotonin reuptake inhibitor (SSRI), to investigate its repercussion on testicular parameters in adult animals. Thirty animals were distributed according to treatment: control animals (n = 6), animals treated with 1 mg kg-1 (n = 6), 5 mg kg-1 (n = 6), 10 mg kg-1 (n = 6) and 20 mg kg-1 (n = 6) of fluoxetine (IP). When 150 days old, the animals were anesthetized and perfused intra-cardiacally with fixative solution. Testes were routinely processed for inclusion in plastic resin (methacrylate glycol). Further, 4 µm-thick histological sections were stained with toluidine blue/sodium borate 1% and analyzed histometrically. Pharmacological intervention on the serotoninergic system during the postnatal period of the testes development in Wistar rats with fluoxetine chlorohydrate reduced parameters, such as testicular weight, testis liquid weight and seminiferous tubules diameter. However, testicular parameters, such as daily sperm production (DSP), spermatogenesis efficiency (DSP/g/testis) and cell population in stage VII of adult animals, were not influenced by fluoxetine chlorohydrate usage during neonatal period. Results show that administration of fluoxetine during 21 days after birth may induce adverse changes in the spermatogenesis of adult rats.
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| first_indexed | 2024-12-12T15:01:30Z |
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| institution | Directory Open Access Journal |
| issn | 1679-9283 1807-863X |
| language | English |
| last_indexed | 2024-12-12T15:01:30Z |
| publishDate | 2012-08-01 |
| publisher | Universidade Estadual de Maringá |
| record_format | Article |
| series | Acta Scientiarum: Biological Sciences |
| spelling | doaj.art-e539e91f385a43a781b269156993d49a2022-12-22T00:20:48ZengUniversidade Estadual de MaringáActa Scientiarum: Biological Sciences1679-92831807-863X2012-08-0135110.4025/actascibiolsci.v35i1.10946<b>Testis evaluation of adult Wistar rats after neonatal treatment with fluoxetine</b> - doi: 10.4025/actascibiolsci.v35i1.10946Valdemiro Amaro da Silva Junior0Waldo Oliveira Monteiro Filho1Catarina Ferreira Pinto2Sandra Maria de Torres3Bruno Mendes Tenorio4Universidade Federal Rural de PernambucoUniversidade Federal Rural de PernambucoUniversidade Federal Rural de PernambucoUniversidade Federal Rural de PernambucoUniversidade Federal Rural de PernambucoIn current assay the serotoninergic system in newly-born Wistar rats underwent pharmacological modification by fluoxetine, a selective serotonin reuptake inhibitor (SSRI), to investigate its repercussion on testicular parameters in adult animals. Thirty animals were distributed according to treatment: control animals (n = 6), animals treated with 1 mg kg-1 (n = 6), 5 mg kg-1 (n = 6), 10 mg kg-1 (n = 6) and 20 mg kg-1 (n = 6) of fluoxetine (IP). When 150 days old, the animals were anesthetized and perfused intra-cardiacally with fixative solution. Testes were routinely processed for inclusion in plastic resin (methacrylate glycol). Further, 4 µm-thick histological sections were stained with toluidine blue/sodium borate 1% and analyzed histometrically. Pharmacological intervention on the serotoninergic system during the postnatal period of the testes development in Wistar rats with fluoxetine chlorohydrate reduced parameters, such as testicular weight, testis liquid weight and seminiferous tubules diameter. However, testicular parameters, such as daily sperm production (DSP), spermatogenesis efficiency (DSP/g/testis) and cell population in stage VII of adult animals, were not influenced by fluoxetine chlorohydrate usage during neonatal period. Results show that administration of fluoxetine during 21 days after birth may induce adverse changes in the spermatogenesis of adult rats. https://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/10946spermatogenesisSertoli cellsperm productionfluoxetine chlorohydrate |
| spellingShingle | Valdemiro Amaro da Silva Junior Waldo Oliveira Monteiro Filho Catarina Ferreira Pinto Sandra Maria de Torres Bruno Mendes Tenorio <b>Testis evaluation of adult Wistar rats after neonatal treatment with fluoxetine</b> - doi: 10.4025/actascibiolsci.v35i1.10946 Acta Scientiarum: Biological Sciences spermatogenesis Sertoli cell sperm production fluoxetine chlorohydrate |
| title | <b>Testis evaluation of adult Wistar rats after neonatal treatment with fluoxetine</b> - doi: 10.4025/actascibiolsci.v35i1.10946 |
| title_full | <b>Testis evaluation of adult Wistar rats after neonatal treatment with fluoxetine</b> - doi: 10.4025/actascibiolsci.v35i1.10946 |
| title_fullStr | <b>Testis evaluation of adult Wistar rats after neonatal treatment with fluoxetine</b> - doi: 10.4025/actascibiolsci.v35i1.10946 |
| title_full_unstemmed | <b>Testis evaluation of adult Wistar rats after neonatal treatment with fluoxetine</b> - doi: 10.4025/actascibiolsci.v35i1.10946 |
| title_short | <b>Testis evaluation of adult Wistar rats after neonatal treatment with fluoxetine</b> - doi: 10.4025/actascibiolsci.v35i1.10946 |
| title_sort | b testis evaluation of adult wistar rats after neonatal treatment with fluoxetine b doi 10 4025 actascibiolsci v35i1 10946 |
| topic | spermatogenesis Sertoli cell sperm production fluoxetine chlorohydrate |
| url | https://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/10946 |
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