Synergistic interactions with PI3K inhibition that induce apoptosis

Synergistic interactions with PI3K inhibition that induce apoptosis

Activating mutations involving the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest, leaving a significant reservoir of tumor cells that may acquire or exhibit resistance. We searched for genes that are required for the survival of PI3K muta...

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Bibliographic Details
Main Authors: Yaara Zwang, Oliver Jonas, Casandra Chen, Mikael L Rinne, John G Doench, Federica Piccioni, Li Tan, Hai-Tsang Huang, Jinhua Wang, Young Jin Ham, Joyce O'Connell, Patrick Bhola, Mihir Doshi, Matthew Whitman, Michael Cima, Anthony Letai, David E Root, Robert S Langer, Nathanael Gray, William C Hahn
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-05-01
Series:eLife
Subjects:
PI3K inhibition
genome-scale shRNA screen
response modifying genes
Online Access:https://elifesciences.org/articles/24523

Internet

https://elifesciences.org/articles/24523

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