Synergistic interactions with PI3K inhibition that induce apoptosis

Synergistic interactions with PI3K inhibition that induce apoptosis

Activating mutations involving the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest, leaving a significant reservoir of tumor cells that may acquire or exhibit resistance. We searched for genes that are required for the survival of PI3K muta...

Full description

Bibliographic Details
Main Authors:	Yaara Zwang, Oliver Jonas, Casandra Chen, Mikael L Rinne, John G Doench, Federica Piccioni, Li Tan, Hai-Tsang Huang, Jinhua Wang, Young Jin Ham, Joyce O'Connell, Patrick Bhola, Mihir Doshi, Matthew Whitman, Michael Cima, Anthony Letai, David E Root, Robert S Langer, Nathanael Gray, William C Hahn
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2017-05-01
Series:	eLife
Subjects:	PI3K inhibition genome-scale shRNA screen response modifying genes
Online Access:	https://elifesciences.org/articles/24523

Similar Items

Synergistic interactions with PI3K inhibition that induce apoptosis
by: Zwang, Yaara, et al.
Published: (2017)

Optimized models for design of efficient miR30-based shRNAs
by: Olga V Matveeva, et al.
Published: (2012-08-01)

Effect of shRNA Survivin-mediated Inhibition of Proliferation in A549 Cells
by: Lihong WU, et al.
Published: (2011-12-01)

Stable silencing of β-lactoglobulin (BLG) gene by lentivirus-mediated RNAi in goat fetal fibroblasts
by: Shumin Zhang, et al.
Published: (2012-01-01)

Focal adhesion kinase is a phospho-regulated repressor of Rac and proliferation in human endothelial cells
by: Patrick W. Bryant, et al.
Published: (2012-06-01)

Stable silencing of β-lactoglobulin (BLG) gene by lentivirus-mediated RNAi in goat fetal fibroblasts
by: Shumin Zhang, et al.
Published: (2012-01-01)

Short hairpin RNA targeting 2B gene of coxsackievirus B3 exhibits potential antiviral effects both <it>in vitro</it> and <it>in vivo</it>
by: Yao Hailan, et al.
Published: (2012-08-01)

Subtype of Neuroblastoma Cells with High KIT Expression Are Dependent on KIT and Its Knockdown Induces Compensatory Activation of Pro-Survival Signaling
by: Timofey Lebedev, et al.
Published: (2022-07-01)

Expression of Chitinase and shRNA Gene Exhibits Resistance to Fungi and Virus
by: Samia Parveen, et al.
Published: (2023-05-01)

Carfilzomib Enhances the Suppressive Effect of Ruxolitinib in Myelofibrosis
by: Simone Claudiani, et al.
Published: (2021-09-01)

Potential genetic robustness of Prnp and Sprn double knockout mouse embryos towards ShRNA-lentiviral inoculation
by: Andrea Rau, et al.
Published: (2022-07-01)

RNA interference targeting virion core protein ORF095 inhibits Goatpox virus replication in Vero cells
by: Zhao Zhixun, et al.
Published: (2012-02-01)

Potent Dystrophin knock-Down in Vitro and in Vivo Using RNAi Technonlogy and Expression Signature of Myotubes with Dystrophin knocked Down: Attempts at Unravelling the Mystery
by: MM Ghahramani Seno, et al.
Published: (2005-10-01)

Finding an Appropriate Mouse Model to Study the Impact of a Treatment for Friedreich Ataxia on the Behavioral Phenotype
by: Camille Bouchard, et al.
Published: (2023-08-01)

Alginate-Chitosan Hydrogels Containing shRNA Plasmid for Inhibition of CTNNB1 Expression in Breast Cancer Cells
by: Birnur Cömez, et al.
Published: (2023-07-01)

Oral Gene Therapy of HFD-Obesity via Nonpathogenic Yeast Microcapsules Mediated shRNA Delivery
by: Li Zhang, et al.
Published: (2021-09-01)

Harnessing Intronic microRNA Structures to Improve Tolerance and Expression of shRNAs in Animal Cells
by: Arjun Challagulla, et al.
Published: (2022-02-01)

Functional Genomic Screening in Human Pluripotent Stem Cells Reveals New Roadblocks in Early Pancreatic Endoderm Formation
by: Jana Krüger, et al.
Published: (2022-02-01)

Effect of shRNA Mediated Silencing of YB-1 Protein on the Expression of Matrix Collagenases in Malignant Melanoma Cell In Vitro
by: Wisam Nabeel Ibrahim, et al.
Published: (2018-01-01)

Stable expression of shRNA for the control of recombinant adenovirus replication
by: M.V.G. Lana, et al.
Published: (2023-07-01)

Electrotransfer of Plasmid DNA Encoding an Anti-Mouse Endoglin (CD105) shRNA to B16 Melanoma Tumors with Low and High Metastatic Potential Results in Pronounced Anti-Tumor Effects
by: Tanja Dolinsek, et al.
Published: (2015-12-01)

Knockdown of SPON2 inhibits the growth of triple-negative breast cancer
by: Xueyi Hu, et al.
Published: (2023-03-01)

Designing Ago2-specific siRNA/shRNA to Avoid Competition with Endogenous miRNAs
by: Hongming Ma, et al.
Published: (2014-01-01)

Inhibition of induced-hepatic cancer in vivo through IQGAP1-shRNA gene therapy and modulation of TRAIL-induced apoptosis pathway
by: Khairy M. A. Zoheir, et al.
Published: (2022-10-01)

Interleukin-6-knockdown of chimeric antigen receptor-modified T cells significantly reduces IL-6 release from monocytes
by: Liqing Kang, et al.
Published: (2020-06-01)

AAV Delivery of shRNA Against TRPC6 in Mouse Hippocampus Impairs Cognitive Function
by: Ruxin Xie, et al.
Published: (2021-07-01)

Genetic Manipulation of Sirtuin 3 Causes Alterations of Key Metabolic Regulators in Melanoma
by: Chandra K. Singh, et al.
Published: (2021-04-01)

Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis
by: Satish K Nandakumar, et al.
Published: (2019-05-01)

Histone deacetylase inhibitors induce medulloblastoma cell death independent of HDACs recruited in REST repression complexes
by: Abdulelah S. Alshawli, et al.
Published: (2020-10-01)

SSD - a free software for designing multimeric mono-, bi- and trivalent shRNAs
by: Gabriel José de Carli, et al.
Published: (2020-03-01)

Recent Findings Concerning PAMAM Dendrimer Conjugates with Cyclodextrins as Carriers of DNA and RNA
by: Keiichi Motoyama, et al.
Published: (2009-08-01)

Reducing farnesyl diphosphate synthase levels activates Vγ9Vδ2 T cells and improves tumor suppression in murine xenograft cancer models
by: Mei-Ling Liou, et al.
Published: (2022-10-01)

Multiplex shRNA Screening of Germ Cell Development by in Vivo Transfection of Mouse Testis
by: Nicholas R. Y. Ho, et al.
Published: (2017-01-01)

Using shRNA experiments to validate gene regulatory networks
by: Catharina Olsen, et al.
Published: (2015-06-01)

Cationic vesicles for efficient shRNA transfection in the MCF-7 breast cancer cell line
by: Mokhtary P, et al.
Published: (2018-11-01)

Enhanced Antiviral Ability by a Combination of Zidovudine and Short Hairpin RNA Targeting Avian Leukosis Virus
by: Qun Wang, et al.
Published: (2022-02-01)

Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration
by: Frank Arnold, et al.
Published: (2021-07-01)

Minimal-length Synthetic shRNAs Formulated with Lipid Nanoparticles are Potent Inhibitors of Hepatitis C Virus IRES-linked Gene Expression in Mice
by: Anne Dallas, et al.
Published: (2013-01-01)

Deep Sequencing Insights in Therapeutic shRNA Processing and siRNA Target Cleavage Precision
by: Hubert Denise, et al.
Published: (2014-01-01)

Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity
by: Sofie Otzen Bagger, et al.
Published: (2018-12-01)