Synergistic and antagonistic drug combinations depend on network topology.

Synergistic and antagonistic drug combinations depend on network topology.

Drug combinations may exhibit synergistic or antagonistic effects. Rational design of synergistic drug combinations remains a challenge despite active experimental and computational efforts. Because drugs manifest their action via their targets, the effects of drug combinations should depend on the...

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Bibliographic Details
Main Authors: Ning Yin, Wenzhe Ma, Jianfeng Pei, Qi Ouyang, Chao Tang, Luhua Lai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3979733?pdf=render

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