In-vivo thrombolytic efficacy of RGD modified protein-polymer conjugated urokinase nanogels

In-vivo thrombolytic efficacy of RGD modified protein-polymer conjugated urokinase nanogels

It has been shown that an arginine-glycine-aspartic acid (RGD) modified pH-triggered delivery system for the urokinase-type plasminogen activator (uPA) is resistant to enzymatic degradation and improves thrombolytic ability in vitro. Herein, we aimed to compare the thrombolytic efficacies of uPA-oxi...

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Bibliographic Details
Main Authors: Xia Liu, Ling-Li Jin, Ling-Ling Zhao, Ya-Chao Wang, Liping Zhang, Zheng-Zheng Huang, Hai-Qiang Jin, Jun-Ying Liu, Zhen-Jiang Liang, Xuan Liu, Hui Tan, Li-Jie Ren
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Polymer Testing
Subjects:
RGD
pH-triggered delivery
Targeted thrombolysis
Stroke
Blood-brain barrier
Online Access:http://www.sciencedirect.com/science/article/pii/S0142941821003378

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