Urticaria and basophils
Chronic spontaneous urticaria (CSU) is a common skin disease without an etiology in the vast majority of cases. The similarity of symptoms and pathology to allergen-induced skin reactions supports that skin mast cell IgE receptor activation is also involved in CSU. Accumulating evidence also support...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Allergology International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S132389302300045X |
| _version_ | 1827916533281587200 |
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| author | Sarbjit S. Saini |
| author_facet | Sarbjit S. Saini |
| author_sort | Sarbjit S. Saini |
| collection | DOAJ |
| description | Chronic spontaneous urticaria (CSU) is a common skin disease without an etiology in the vast majority of cases. The similarity of symptoms and pathology to allergen-induced skin reactions supports that skin mast cell IgE receptor activation is also involved in CSU. Accumulating evidence also supports a role for blood basophils in disease expression. Blood basopenia is noted in active CSU disease with the recruitment of blood basophils to skin lesion sites. Blood basophils further display altered IgE receptor mediated degranulation patterns in two phenotypes that improve in remission. In active CSU subjects, changes in IgE receptor signaling molecule expression levels accompany the altered degranulation function in blood basophils. The success of therapies targeting IgE in CSU patients have also shown that altered blood basophil phenotypes and enumeration have potential use as a disease biomarker. |
| first_indexed | 2024-03-13T03:15:31Z |
| format | Article |
| id | doaj.art-e540c3a0ad5643b685ed208b8daec86b |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-03-13T03:15:31Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-e540c3a0ad5643b685ed208b8daec86b2023-06-26T04:13:40ZengElsevierAllergology International1323-89302023-07-01723369374Urticaria and basophilsSarbjit S. Saini0Division of Allergy & Clinical Immunology, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Room 2B 71B, Baltimore, MD, 21224, USAChronic spontaneous urticaria (CSU) is a common skin disease without an etiology in the vast majority of cases. The similarity of symptoms and pathology to allergen-induced skin reactions supports that skin mast cell IgE receptor activation is also involved in CSU. Accumulating evidence also supports a role for blood basophils in disease expression. Blood basopenia is noted in active CSU disease with the recruitment of blood basophils to skin lesion sites. Blood basophils further display altered IgE receptor mediated degranulation patterns in two phenotypes that improve in remission. In active CSU subjects, changes in IgE receptor signaling molecule expression levels accompany the altered degranulation function in blood basophils. The success of therapies targeting IgE in CSU patients have also shown that altered blood basophil phenotypes and enumeration have potential use as a disease biomarker.http://www.sciencedirect.com/science/article/pii/S132389302300045XBasophilsFceRIHivesIgEUrticaria |
| spellingShingle | Sarbjit S. Saini Urticaria and basophils Allergology International Basophils FceRI Hives IgE Urticaria |
| title | Urticaria and basophils |
| title_full | Urticaria and basophils |
| title_fullStr | Urticaria and basophils |
| title_full_unstemmed | Urticaria and basophils |
| title_short | Urticaria and basophils |
| title_sort | urticaria and basophils |
| topic | Basophils FceRI Hives IgE Urticaria |
| url | http://www.sciencedirect.com/science/article/pii/S132389302300045X |
| work_keys_str_mv | AT sarbjitssaini urticariaandbasophils |