Cutoffs of different body measurement indexes of central obesity in patients with type 2 diabetes
Abstract Few research discuss whether the body measurement indexs of obesity in general populations is applicable to patients with type 2 diabetes. We explore the optimal cutoffs of visceral fat area (VFA) and subcutaneous fat area (SFA) in the diagnosis of central obesity and the cutoffs of corresp...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-01-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-52645-9 |
| _version_ | 1797276576972275712 |
|---|---|
| author | Ai Luo Zheng Tang XiaoJia Xu Chao Li Die Zhou Dong Xiao Yongjie Lu Rutao Liang Guifen Guan Wangen Li Zhuoqing Hu |
| author_facet | Ai Luo Zheng Tang XiaoJia Xu Chao Li Die Zhou Dong Xiao Yongjie Lu Rutao Liang Guifen Guan Wangen Li Zhuoqing Hu |
| author_sort | Ai Luo |
| collection | DOAJ |
| description | Abstract Few research discuss whether the body measurement indexs of obesity in general populations is applicable to patients with type 2 diabetes. We explore the optimal cutoffs of visceral fat area (VFA) and subcutaneous fat area (SFA) in the diagnosis of central obesity and the cutoffs of corresponding waist circumference (WC) and body mass index (BMI) in patients with Type 2 Diabetes (T2D). Cross-sectional cohort study. 1057 patients with T2D (550 males and 507 females) aged 18 or above that satisfied the criteria were included. The definition and diagnostic criteria of Metabolic syndrome (Mets) were analyzed according to the 2020 Chinese Diabetes Society (CDS) Guideline. The VFA and SFA were measured by bioelectrical impedance analysis (BIA). The optimal VFA and SFA cutoffs and corresponding WC and BMI when two or more nonadipose components of MetS (without central obesity) were met were analyzed by ROC curve. Among all of the T2D patients, the optimal VFA cutoff for identifying two or more nonadipose components of MetS was 73.30 cm2 for females and 69.20 cm2 for males, while the optimal SFA cutoff was 186.70 cm2 for females and 123.30 cm2 for males. The ROC area under curve (AUC) of VFA for identifying two or more nonadipose components of MetS was higher than that of SFA (Female: 0.65 vs. 0.58, P = 0.01). The VFA cutoff of newly diagnosed T2D patients (females = 86.10 cm2, males = 69.00 cm2) was higher than that of non-newly diagnosed T2D patients (females = 73.30 cm2, males = 65.40 cm2). A stratification analysis of gender and whether newly diagnosed with T2D or not showed that the WCs corresponding to VFA were 85.00 cm and BMI was about 24.00 kg/m2. VFA measured by BIA can be a non-invasive method to detect central obesity in patients with T2D, the corresponding WC were 85.00 cm and BMI was 24.00 kg/m2. |
| first_indexed | 2024-03-07T15:31:10Z |
| format | Article |
| id | doaj.art-e540fa1338d24fffb6dcdb6f6a48f7d6 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:31:10Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e540fa1338d24fffb6dcdb6f6a48f7d62024-03-05T16:28:04ZengNature PortfolioScientific Reports2045-23222024-01-0114111010.1038/s41598-024-52645-9Cutoffs of different body measurement indexes of central obesity in patients with type 2 diabetesAi Luo0Zheng Tang1XiaoJia Xu2Chao Li3Die Zhou4Dong Xiao5Yongjie Lu6Rutao Liang7Guifen Guan8Wangen Li9Zhuoqing Hu10Department of Endocrinology, The Second Affiliated Hospital of Guangzhou Medical UniversityGuangdong Medical UniversityDepartment of Endocrinology, The Second Affiliated Hospital of Guangzhou Medical UniversityGuangdong Medical UniversityDepartment of Laboratory, The Second Affiliated Hospital of Guangzhou Medical UniversityDepartment of Endocrinology, The Second Affiliated Hospital of Guangzhou Medical UniversitySchool of Public Health, Guangzhou Medical UniversityGuangdong Medical UniversityDepartment of Endocrinology, The Second Affiliated Hospital of Guangzhou Medical UniversityDepartment of Endocrinology, The Second Affiliated Hospital of Guangzhou Medical UniversityDepartment of Endocrinology, The Second Affiliated Hospital of Guangzhou Medical UniversityAbstract Few research discuss whether the body measurement indexs of obesity in general populations is applicable to patients with type 2 diabetes. We explore the optimal cutoffs of visceral fat area (VFA) and subcutaneous fat area (SFA) in the diagnosis of central obesity and the cutoffs of corresponding waist circumference (WC) and body mass index (BMI) in patients with Type 2 Diabetes (T2D). Cross-sectional cohort study. 1057 patients with T2D (550 males and 507 females) aged 18 or above that satisfied the criteria were included. The definition and diagnostic criteria of Metabolic syndrome (Mets) were analyzed according to the 2020 Chinese Diabetes Society (CDS) Guideline. The VFA and SFA were measured by bioelectrical impedance analysis (BIA). The optimal VFA and SFA cutoffs and corresponding WC and BMI when two or more nonadipose components of MetS (without central obesity) were met were analyzed by ROC curve. Among all of the T2D patients, the optimal VFA cutoff for identifying two or more nonadipose components of MetS was 73.30 cm2 for females and 69.20 cm2 for males, while the optimal SFA cutoff was 186.70 cm2 for females and 123.30 cm2 for males. The ROC area under curve (AUC) of VFA for identifying two or more nonadipose components of MetS was higher than that of SFA (Female: 0.65 vs. 0.58, P = 0.01). The VFA cutoff of newly diagnosed T2D patients (females = 86.10 cm2, males = 69.00 cm2) was higher than that of non-newly diagnosed T2D patients (females = 73.30 cm2, males = 65.40 cm2). A stratification analysis of gender and whether newly diagnosed with T2D or not showed that the WCs corresponding to VFA were 85.00 cm and BMI was about 24.00 kg/m2. VFA measured by BIA can be a non-invasive method to detect central obesity in patients with T2D, the corresponding WC were 85.00 cm and BMI was 24.00 kg/m2.https://doi.org/10.1038/s41598-024-52645-9 |
| spellingShingle | Ai Luo Zheng Tang XiaoJia Xu Chao Li Die Zhou Dong Xiao Yongjie Lu Rutao Liang Guifen Guan Wangen Li Zhuoqing Hu Cutoffs of different body measurement indexes of central obesity in patients with type 2 diabetes Scientific Reports |
| title | Cutoffs of different body measurement indexes of central obesity in patients with type 2 diabetes |
| title_full | Cutoffs of different body measurement indexes of central obesity in patients with type 2 diabetes |
| title_fullStr | Cutoffs of different body measurement indexes of central obesity in patients with type 2 diabetes |
| title_full_unstemmed | Cutoffs of different body measurement indexes of central obesity in patients with type 2 diabetes |
| title_short | Cutoffs of different body measurement indexes of central obesity in patients with type 2 diabetes |
| title_sort | cutoffs of different body measurement indexes of central obesity in patients with type 2 diabetes |
| url | https://doi.org/10.1038/s41598-024-52645-9 |
| work_keys_str_mv | AT ailuo cutoffsofdifferentbodymeasurementindexesofcentralobesityinpatientswithtype2diabetes AT zhengtang cutoffsofdifferentbodymeasurementindexesofcentralobesityinpatientswithtype2diabetes AT xiaojiaxu cutoffsofdifferentbodymeasurementindexesofcentralobesityinpatientswithtype2diabetes AT chaoli cutoffsofdifferentbodymeasurementindexesofcentralobesityinpatientswithtype2diabetes AT diezhou cutoffsofdifferentbodymeasurementindexesofcentralobesityinpatientswithtype2diabetes AT dongxiao cutoffsofdifferentbodymeasurementindexesofcentralobesityinpatientswithtype2diabetes AT yongjielu cutoffsofdifferentbodymeasurementindexesofcentralobesityinpatientswithtype2diabetes AT rutaoliang cutoffsofdifferentbodymeasurementindexesofcentralobesityinpatientswithtype2diabetes AT guifenguan cutoffsofdifferentbodymeasurementindexesofcentralobesityinpatientswithtype2diabetes AT wangenli cutoffsofdifferentbodymeasurementindexesofcentralobesityinpatientswithtype2diabetes AT zhuoqinghu cutoffsofdifferentbodymeasurementindexesofcentralobesityinpatientswithtype2diabetes |