In-Silico Characterization of von Willebrand Factor Bound to FVIII

In-Silico Characterization of von Willebrand Factor Bound to FVIII

Factor VIII belongs to the coagulation cascade and is expressed as a long pre-protein (mature form, 2351 amino acids long). FVIII is deficient or defective in hemophilic A patients, who need to be treated with hemoderivatives or recombinant FVIII substitutes, i.e., biologic drugs. The interaction be...

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Bibliographic Details
Main Authors: Valentina Drago, Luisa Di Paola, Claire Lesieur, Renato Bernardini, Claudio Bucolo, Chiara Bianca Maria Platania
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Applied Sciences
Subjects:
hemophilia A
FVIII
von Willebrand Factor
protein contact networks
bioinformatics
biologic drugs
Online Access:https://www.mdpi.com/2076-3417/12/15/7855

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