Mesenchymal stem cell-derived extracellular vesicles ameliorate renal interstitial fibrosis via the miR-13474/ADAM17 axis

Mesenchymal stem cell-derived extracellular vesicles ameliorate renal interstitial fibrosis via the miR-13474/ADAM17 axis

Abstract Renal interstitial fibrosis (RIF) is a prevalent consequence of chronic renal diseases, characterized by excessive extracellular matrix (ECM) deposition. A Disintegrin and Metalloprotease 17 (ADAM17), a transmembrane metalloproteinase, plays a central role in driving renal fibrosis progress...

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Bibliographic Details
Main Authors: Linru Shi, Yuyan Hu, Houcheng Zeng, Hui Shi, Wenrong Xu, Yaoxiang Sun, Hong Chu, Cheng Ji, Hui Qian
Format: Article
Language:English
Published: Nature Portfolio 2024-07-01
Series:Scientific Reports
Subjects:
Renal fibrosis
HucMSC
Extracellular vesicles
miR-13474
ADAM17
Online Access:https://doi.org/10.1038/s41598-024-67339-5

Internet

https://doi.org/10.1038/s41598-024-67339-5

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