Neoadjuvant treatment for pancreatic cancer: Controversies and advances
Despite the advancements in the treatment of localized pancreatic cancer, several unresolved issues persist in clinical practice, especially in the neoadjuvant setting. These include determining the criteria for selecting patients for treatment, identifying the most effective chemotherapy regimens,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Cancer Treatment and Research Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468294224000169 |
| _version_ | 1797253941218508800 |
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| author | Douglas Dias e Silva Vincent Chung |
| author_facet | Douglas Dias e Silva Vincent Chung |
| author_sort | Douglas Dias e Silva |
| collection | DOAJ |
| description | Despite the advancements in the treatment of localized pancreatic cancer, several unresolved issues persist in clinical practice, especially in the neoadjuvant setting. These include determining the criteria for selecting patients for treatment, identifying the most effective chemotherapy regimens, understanding the role of radiotherapy, and accurately assessing how patients respond to treatment. Current strategies for assessing patients before surgery involve thoroughly evaluating their overall health status, analyzing tumor markers, and using advanced imaging techniques. However, existing methods for staging the disease still have limitations when it comes to accurately detecting metastatic cancer. The ongoing debate between performing surgery upfront or administering neoadjuvant therapy highlights the need for robust clinical evidence to guide treatment decisions effectively. This review analyzes the evidence regarding controversial topics in neoadjuvant pancreatic cancer treatment and discusses further research efforts to enhance patient outcomes. To improve the outcomes found with surgery alone, multimodal treatment with chemotherapy. |
| first_indexed | 2024-04-24T21:42:03Z |
| format | Article |
| id | doaj.art-e544bc858c8a410d9324365281b863da |
| institution | Directory Open Access Journal |
| issn | 2468-2942 |
| language | English |
| last_indexed | 2024-04-24T21:42:03Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Treatment and Research Communications |
| spelling | doaj.art-e544bc858c8a410d9324365281b863da2024-03-21T05:37:16ZengElsevierCancer Treatment and Research Communications2468-29422024-01-0139100804Neoadjuvant treatment for pancreatic cancer: Controversies and advancesDouglas Dias e Silva0Vincent Chung1City of Hope, 1500 E. Duarte Road, Duarte, CA 91010, United StatesCorresponding author.; City of Hope, 1500 E. Duarte Road, Duarte, CA 91010, United StatesDespite the advancements in the treatment of localized pancreatic cancer, several unresolved issues persist in clinical practice, especially in the neoadjuvant setting. These include determining the criteria for selecting patients for treatment, identifying the most effective chemotherapy regimens, understanding the role of radiotherapy, and accurately assessing how patients respond to treatment. Current strategies for assessing patients before surgery involve thoroughly evaluating their overall health status, analyzing tumor markers, and using advanced imaging techniques. However, existing methods for staging the disease still have limitations when it comes to accurately detecting metastatic cancer. The ongoing debate between performing surgery upfront or administering neoadjuvant therapy highlights the need for robust clinical evidence to guide treatment decisions effectively. This review analyzes the evidence regarding controversial topics in neoadjuvant pancreatic cancer treatment and discusses further research efforts to enhance patient outcomes. To improve the outcomes found with surgery alone, multimodal treatment with chemotherapy.http://www.sciencedirect.com/science/article/pii/S2468294224000169Pancreas cancerNeoadjuvant therapy |
| spellingShingle | Douglas Dias e Silva Vincent Chung Neoadjuvant treatment for pancreatic cancer: Controversies and advances Cancer Treatment and Research Communications Pancreas cancer Neoadjuvant therapy |
| title | Neoadjuvant treatment for pancreatic cancer: Controversies and advances |
| title_full | Neoadjuvant treatment for pancreatic cancer: Controversies and advances |
| title_fullStr | Neoadjuvant treatment for pancreatic cancer: Controversies and advances |
| title_full_unstemmed | Neoadjuvant treatment for pancreatic cancer: Controversies and advances |
| title_short | Neoadjuvant treatment for pancreatic cancer: Controversies and advances |
| title_sort | neoadjuvant treatment for pancreatic cancer controversies and advances |
| topic | Pancreas cancer Neoadjuvant therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2468294224000169 |
| work_keys_str_mv | AT douglasdiasesilva neoadjuvanttreatmentforpancreaticcancercontroversiesandadvances AT vincentchung neoadjuvanttreatmentforpancreaticcancercontroversiesandadvances |