Fluid shear stress impacts ovarian cancer cell viability, subcellular organization, and promotes genomic instability.

Fluid shear stress impacts ovarian cancer cell viability, subcellular organization, and promotes genomic instability.

Ovarian cancer cells are exposed to physical stress in the peritoneal cavity during both tumor growth and dissemination. Ascites build-up in metastatic ovarian cancer further increases the exposure to fluid shear stress. Here, we used a murine, in vitro ovarian cancer progression model in parallel w...

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Bibliographic Details
Main Authors: Alexandra R Hyler, Nicolaas C Baudoin, Megan S Brown, Mark A Stremler, Daniela Cimini, Rafael V Davalos, Eva M Schmelz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5864000?pdf=render

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