Prospective multicentre Italian pregnancy cohort study (SIMPLE) on the associations of maternal first trimester SIMPLE nutritional score with early placental function markers and pregnancy outcomes
Introduction Currently, the adherence to nutritional guidelines is low, with alarming rates of obesity worldwide and micronutrient deficiencies documented even in industrialised countries. As a consequence, nutritional screening and counselling represent a critical subject in early pregnancy, aiming...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2022-10-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/10/e062940.full |
| _version_ | 1811197028498145280 |
|---|---|
| author | A Lanzone F Zullo S Angioni A Spinillo E Cicinelli Irene Cetin P Greco Francesca Parisi N Di Simone M Franchi M Guido F Facchinetti F Petraglia T Simoncini Chiara Coco V Savasi M Vignali G Di Renzo C Benedetto R D’Anna L Nappi N Colacurci S Guerriero |
| author_facet | A Lanzone F Zullo S Angioni A Spinillo E Cicinelli Irene Cetin P Greco Francesca Parisi N Di Simone M Franchi M Guido F Facchinetti F Petraglia T Simoncini Chiara Coco V Savasi M Vignali G Di Renzo C Benedetto R D’Anna L Nappi N Colacurci S Guerriero |
| collection | DOAJ |
| description | Introduction Currently, the adherence to nutritional guidelines is low, with alarming rates of obesity worldwide and micronutrient deficiencies documented even in industrialised countries. As a consequence, nutritional screening and counselling represent a critical subject in early pregnancy, aiming to improve pregnancy outcomes and population health.Methods and analysis In this setting, the development of a simple and reproducible nutritional checklist is of utmost importance. The Simple Study is a longitudinal prospective multicentre study aiming to identify the associations between maternal nutritional habits in the first trimester, early markers of placental function and pregnancy outcomes on a large population of singleton pregnancies in Italy.Ongoing healthy singleton pregnancies will be enrolled at the ultrasound scan of the first trimester combined screening test (11+0–13+6 gestational weeks). A nutritional score measuring the adherence to a healthy diet and nutritional deficiencies will be collected at recruitment. Fetal (crown-rump length, nuchal translucency (NT), biparietal diameter, femur length) and utero placental (placental volume, uterine arteries Doppler velocimetry) ultrasound data and biochemical placental markers (pregnancy-associated plasma protein A, free ß-human chorionic gonadotropin) will be collected. Second and third trimester ultrasound records and birth outcomes will be recorded from medical registers. This study will set the stage for introducing a reproducible, time-saving and low-cost nutritional screening in pregnancy. The nutritional score will allow the implementation of specific corrective measures with potential large impact on placentation and pregnancy outcomes.Ethical and dissemination Ethical approval for this study was obtained from the Milano Area 1 Ethics Committee (No 46091, 7 November 2018) prior to the commencement of the research.The dissemination plan includes the presentation of abstracts and findings at national and international scientific meetings. |
| first_indexed | 2024-04-12T01:09:25Z |
| format | Article |
| id | doaj.art-e549d9c5173f42cf85e1cbcea954c2c5 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-12T01:09:25Z |
| publishDate | 2022-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-e549d9c5173f42cf85e1cbcea954c2c52022-12-22T03:54:10ZengBMJ Publishing GroupBMJ Open2044-60552022-10-01121010.1136/bmjopen-2022-062940Prospective multicentre Italian pregnancy cohort study (SIMPLE) on the associations of maternal first trimester SIMPLE nutritional score with early placental function markers and pregnancy outcomes A LanzoneF ZulloS AngioniA SpinilloE CicinelliIrene Cetin0P GrecoFrancesca Parisi1N Di SimoneM FranchiM GuidoF FacchinettiF PetragliaT SimonciniChiara Coco2V SavasiM VignaliG Di RenzoC BenedettoR D’AnnaL NappiN ColacurciS GuerrieroObstetrics and Gynecology, Vittore Buzzi Children`s Hospital, Milano, ItalyObstetrics and Gynecology, Vittore Buzzi Children`s Hospital, Milano, ItalyObstetrics and Gynecology, Vittore Buzzi Children`s Hospital, Milano, ItalyIntroduction Currently, the adherence to nutritional guidelines is low, with alarming rates of obesity worldwide and micronutrient deficiencies documented even in industrialised countries. As a consequence, nutritional screening and counselling represent a critical subject in early pregnancy, aiming to improve pregnancy outcomes and population health.Methods and analysis In this setting, the development of a simple and reproducible nutritional checklist is of utmost importance. The Simple Study is a longitudinal prospective multicentre study aiming to identify the associations between maternal nutritional habits in the first trimester, early markers of placental function and pregnancy outcomes on a large population of singleton pregnancies in Italy.Ongoing healthy singleton pregnancies will be enrolled at the ultrasound scan of the first trimester combined screening test (11+0–13+6 gestational weeks). A nutritional score measuring the adherence to a healthy diet and nutritional deficiencies will be collected at recruitment. Fetal (crown-rump length, nuchal translucency (NT), biparietal diameter, femur length) and utero placental (placental volume, uterine arteries Doppler velocimetry) ultrasound data and biochemical placental markers (pregnancy-associated plasma protein A, free ß-human chorionic gonadotropin) will be collected. Second and third trimester ultrasound records and birth outcomes will be recorded from medical registers. This study will set the stage for introducing a reproducible, time-saving and low-cost nutritional screening in pregnancy. The nutritional score will allow the implementation of specific corrective measures with potential large impact on placentation and pregnancy outcomes.Ethical and dissemination Ethical approval for this study was obtained from the Milano Area 1 Ethics Committee (No 46091, 7 November 2018) prior to the commencement of the research.The dissemination plan includes the presentation of abstracts and findings at national and international scientific meetings.https://bmjopen.bmj.com/content/12/10/e062940.full |
| spellingShingle | A Lanzone F Zullo S Angioni A Spinillo E Cicinelli Irene Cetin P Greco Francesca Parisi N Di Simone M Franchi M Guido F Facchinetti F Petraglia T Simoncini Chiara Coco V Savasi M Vignali G Di Renzo C Benedetto R D’Anna L Nappi N Colacurci S Guerriero Prospective multicentre Italian pregnancy cohort study (SIMPLE) on the associations of maternal first trimester SIMPLE nutritional score with early placental function markers and pregnancy outcomes BMJ Open |
| title | Prospective multicentre Italian pregnancy cohort study (SIMPLE) on the associations of maternal first trimester SIMPLE nutritional score with early placental function markers and pregnancy outcomes |
| title_full | Prospective multicentre Italian pregnancy cohort study (SIMPLE) on the associations of maternal first trimester SIMPLE nutritional score with early placental function markers and pregnancy outcomes |
| title_fullStr | Prospective multicentre Italian pregnancy cohort study (SIMPLE) on the associations of maternal first trimester SIMPLE nutritional score with early placental function markers and pregnancy outcomes |
| title_full_unstemmed | Prospective multicentre Italian pregnancy cohort study (SIMPLE) on the associations of maternal first trimester SIMPLE nutritional score with early placental function markers and pregnancy outcomes |
| title_short | Prospective multicentre Italian pregnancy cohort study (SIMPLE) on the associations of maternal first trimester SIMPLE nutritional score with early placental function markers and pregnancy outcomes |
| title_sort | prospective multicentre italian pregnancy cohort study simple on the associations of maternal first trimester simple nutritional score with early placental function markers and pregnancy outcomes |
| url | https://bmjopen.bmj.com/content/12/10/e062940.full |
| work_keys_str_mv | AT prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT alanzone prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT fzullo prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT sangioni prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT aspinillo prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT ecicinelli prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT irenecetin prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT pgreco prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT francescaparisi prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT ndisimone prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT mfranchi prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT mguido prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT ffacchinetti prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT fpetraglia prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT tsimoncini prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT chiaracoco prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT vsavasi prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT mvignali prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT gdirenzo prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT cbenedetto prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT rdanna prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT lnappi prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT ncolacurci prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes AT sguerriero prospectivemulticentreitalianpregnancycohortstudysimpleontheassociationsofmaternalfirsttrimestersimplenutritionalscorewithearlyplacentalfunctionmarkersandpregnancyoutcomes |