The Boron Advantage: The Evolution and Diversification of Boron’s Applications in Medicinal Chemistry
In this review, the history of boron’s early use in drugs, and the history of the use of boron functional groups in medicinal chemistry applications are discussed. This includes diazaborines, boronic acids, benzoxaboroles, boron clusters, and carboranes. Furthermore, critical developments from these...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/15/3/264 |
| _version_ | 1797443729498308608 |
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| author | Katia Messner Billy Vuong Geoffrey K. Tranmer |
| author_facet | Katia Messner Billy Vuong Geoffrey K. Tranmer |
| author_sort | Katia Messner |
| collection | DOAJ |
| description | In this review, the history of boron’s early use in drugs, and the history of the use of boron functional groups in medicinal chemistry applications are discussed. This includes diazaborines, boronic acids, benzoxaboroles, boron clusters, and carboranes. Furthermore, critical developments from these functional groups are highlighted along with recent developments, which exemplify potential prospects. Lastly, the application of boron in the form of a prodrug, softdrug, and as a nanocarrier are discussed to showcase boron’s emergence into new and exciting fields. Overall, we emphasize the evolution of organoboron therapeutic agents as privileged structures in medicinal chemistry and outline the impact that boron has had on drug discovery and development. |
| first_indexed | 2024-03-09T13:02:14Z |
| format | Article |
| id | doaj.art-e549f4fc79564bc8bf28c262211d56cd |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T13:02:14Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-e549f4fc79564bc8bf28c262211d56cd2023-11-30T21:53:42ZengMDPI AGPharmaceuticals1424-82472022-02-0115326410.3390/ph15030264The Boron Advantage: The Evolution and Diversification of Boron’s Applications in Medicinal ChemistryKatia Messner0Billy Vuong1Geoffrey K. Tranmer2Rady Faculty of Health Science, College of Pharmacy, University of Manitoba, Winnipeg, MB R3E 0T5, CanadaRady Faculty of Health Science, College of Pharmacy, University of Manitoba, Winnipeg, MB R3E 0T5, CanadaRady Faculty of Health Science, College of Pharmacy, University of Manitoba, Winnipeg, MB R3E 0T5, CanadaIn this review, the history of boron’s early use in drugs, and the history of the use of boron functional groups in medicinal chemistry applications are discussed. This includes diazaborines, boronic acids, benzoxaboroles, boron clusters, and carboranes. Furthermore, critical developments from these functional groups are highlighted along with recent developments, which exemplify potential prospects. Lastly, the application of boron in the form of a prodrug, softdrug, and as a nanocarrier are discussed to showcase boron’s emergence into new and exciting fields. Overall, we emphasize the evolution of organoboron therapeutic agents as privileged structures in medicinal chemistry and outline the impact that boron has had on drug discovery and development.https://www.mdpi.com/1424-8247/15/3/264boronmedicinal chemistrydiazaborinesboronic acidsboron clusterscarboranes |
| spellingShingle | Katia Messner Billy Vuong Geoffrey K. Tranmer The Boron Advantage: The Evolution and Diversification of Boron’s Applications in Medicinal Chemistry Pharmaceuticals boron medicinal chemistry diazaborines boronic acids boron clusters carboranes |
| title | The Boron Advantage: The Evolution and Diversification of Boron’s Applications in Medicinal Chemistry |
| title_full | The Boron Advantage: The Evolution and Diversification of Boron’s Applications in Medicinal Chemistry |
| title_fullStr | The Boron Advantage: The Evolution and Diversification of Boron’s Applications in Medicinal Chemistry |
| title_full_unstemmed | The Boron Advantage: The Evolution and Diversification of Boron’s Applications in Medicinal Chemistry |
| title_short | The Boron Advantage: The Evolution and Diversification of Boron’s Applications in Medicinal Chemistry |
| title_sort | boron advantage the evolution and diversification of boron s applications in medicinal chemistry |
| topic | boron medicinal chemistry diazaborines boronic acids boron clusters carboranes |
| url | https://www.mdpi.com/1424-8247/15/3/264 |
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