The role of opioid receptors in modulating Alzheimer’s Disease

The role of opioid receptors in modulating Alzheimer’s Disease

Alzheimer’s disease (AD) is a complex neurological disorder characterized by accumulation of amyloid plaques and neurofibrillary tangles. Long term investigation of AD pathogenesis suggests that β-site amyloid precursor protein [APP] cleaving enzyme 1 (BACE1) and γ-secretase enzymes promote the amyl...

Full description

Bibliographic Details
Main Authors:	Parthasaradhireddy Tanguturi, John M. Streicher
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-03-01
Series:	Frontiers in Pharmacology
Subjects:	neurodegenerative disorders Alzheimer’s disease opioid receptors β-secretase-1 amyloid-β
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1056402/full

Similar Items

Discovery of Novel Delta Opioid Receptor (DOR) Inverse Agonist and Irreversible (Non-Competitive) Antagonists
by: Parthasaradhireddy Tanguturi, et al.
Published: (2021-11-01)

Scaffold Morphing and In Silico Design of Potential BACE-1 (β-Secretase) Inhibitors: A Hope for a Newer Dawn in Anti-Alzheimer Therapeutics
by: Shiveena Bhatia, et al.
Published: (2023-08-01)

Glycosaminoglycans from <i>Litopenaeus vannamei</i> Inhibit the Alzheimer’s Disease β Secretase, BACE1
by: Courtney J. Mycroft-West, et al.
Published: (2021-04-01)

Neuroprotective Activity of <i>Mentha</i> Species on Hydrogen Peroxide-Induced Apoptosis in SH-SY5Y Cells
by: Doaa M. Hanafy, et al.
Published: (2020-05-01)

Ex vivo analysis platforms for monitoring amyloid precursor protein cleavage
by: Yuji Kamikubo, et al.
Published: (2023-01-01)

Krüppel-like factor 5 accelerates the pathogenesis of Alzheimer’s disease via BACE1-mediated APP processing
by: Yaqi Wang, et al.
Published: (2022-07-01)

Late-long-term potentiation magnitude, but not Aβ levels and amyloid pathology, is associated with behavioral performance in a rat knock-in model of Alzheimer disease
by: Metin Yesiltepe, et al.
Published: (2022-11-01)

The Large Ectodomain of APP Prevents APP from being Directly Cleaved by γ-Secretase
by: Yuan Li, et al.
Published: (2024-02-01)

Synthesis and Characterization of Andrographolide Derivatives as Regulators of βAPP Processing in Human Cells
by: Arpita Dey, et al.
Published: (2021-12-01)

Gamma-secretase modulators: a promising route for the treatment of Alzheimer's disease
by: Gunnar Nordvall, et al.
Published: (2023-10-01)

In silico and in vitro assessment of the anti-β-amyloid aggregation and anti-cholinesterase activities of Ptaeroxylon obliquum and Bauhinia bowkeri extracts
by: Michael C. Ojo, et al.
Published: (2024-03-01)

Modulation of γ-Secretase Activity by a Carborane-Based Flurbiprofen Analogue
by: Stefan Saretz, et al.
Published: (2021-05-01)

Royal Jelly as an Intelligent Anti-Aging Agent—A Focus on Cognitive Aging and Alzheimer’s Disease: A Review
by: Amira Mohammed Ali, et al.
Published: (2020-09-01)

Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol
by: Vladimir Rudajev, et al.
Published: (2023-09-01)

Discovery of Compounds That Selectively Repress the Amyloidogenic Processing of the Amyloid Precursor Protein: Design, Synthesis and Pharmacological Evaluation of Diphenylpyrazoles
by: Christophe Mesangeau, et al.
Published: (2022-10-01)

Trans-Cinnamaldehyde Alleviates Amyloid-Beta Pathogenesis via the SIRT1-PGC1α-PPARγ Pathway in 5XFAD Transgenic Mice
by: Jimin Do, et al.
Published: (2020-06-01)

Synthesis and In Vitro Characterization of Glycopeptide Drug Candidates Related to PACAP<sub>1–23</sub>
by: Christopher R. Apostol, et al.
Published: (2021-08-01)

Sleep disorders and Alzheimer’s disease
by: A. N. Bogolepova
Published: (2018-04-01)

Changes in Aβ42, Neprilysin, and γ-Secretase in the Hippocampus of Male Rats Alzheimer’s model: The Effects of Aerobic Training and Omega-3 Intake
by: Ali Yaghoubi
Published: (2023-06-01)

Microglial Transforming Growth Factor-β Signaling in Alzheimer’s Disease
by: Natascha Vidovic, et al.
Published: (2024-03-01)

The efficacy and safety of anti-Aβ agents for delaying cognitive decline in Alzheimer’s disease: a meta-analysis
by: Jiaxuan Li, et al.
Published: (2023-11-01)

Correction: Tanguturi et al. Discovery of Novel Delta Opioid Receptor (DOR) Inverse Agonist and Irreversible (Non-Competitive) Antagonists. <i>Molecules</i> 2021, <i>26</i>, 6693
by: Parthasaradhireddy Tanguturi, et al.
Published: (2022-03-01)

The Role of Salivary Biomarkers in the Early Diagnosis of Alzheimer’s Disease and Parkinson’s Disease
by: Patrycja Pawlik, et al.
Published: (2021-02-01)

Alzheimer’s Disease: Models and Molecular Mechanisms Informing Disease and Treatments
by: Kaden L. Nystuen, et al.
Published: (2024-01-01)

Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors
by: Keith D. Green, et al.
Published: (2018-12-01)

Alzheimer’s Disease: Current and Future Treatments. A Review
by: Evelyn Chou
Published: (2014-05-01)

Therapeutic Potentials of Microalgae in the Treatment of Alzheimer’s Disease
by: Tosin A. Olasehinde, et al.
Published: (2017-03-01)

Alzheimer’s Disease: A Brief History of Immunotherapies Targeting Amyloid β
by: Anne-Cathrine S. Vogt, et al.
Published: (2023-02-01)

Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer’s Disease: A Narrative Review
by: Silvia Di Giacomo, et al.
Published: (2022-09-01)

Link between Diabetes and Alzheimer’s Disease Due to the Shared Amyloid Aggregation and Deposition Involving Both Neurodegenerative Changes and Neurovascular Damages
by: Gabriela Dumitrita Stanciu, et al.
Published: (2020-06-01)

he amyloid hypothesis of Alzheimer's disease: past and present, hopes and disappointments
by: I. V. Litvinenko, et al.
Published: (2019-11-01)

Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis
by: Lukas P Feilen, et al.
Published: (2022-05-01)

The Anti-Aggregative Peptide KLVFF Mimics Aβ1-40 in the Modulation of Nicotinic Receptors: Implications for Peptide-Based Therapy
by: Hanna Trebesova, et al.
Published: (2022-09-01)

Identification of methylation-regulated genes modulating microglial phagocytosis in hyperhomocysteinemia-exacerbated Alzheimer’s disease
by: Xianwei Wang, et al.
Published: (2023-10-01)

High Cerebrospinal Fluid CX3CL1 Levels in Alzheimer’s Disease Patients but Not in Non-Alzheimer’s Disease Dementia
by: Giulia Bivona, et al.
Published: (2022-09-01)

The Role of PGC1α in Alzheimer’s Disease and Therapeutic Interventions
by: Bibiana C. Mota, et al.
Published: (2021-05-01)

The emerging double-edged sword role of exosomes in Alzheimer’s disease
by: Tao Liang, et al.
Published: (2023-06-01)

Blocking beta 2-adrenergic receptor inhibits dendrite ramification in a mouse model of Alzheimer's disease
by: Qin Wu, et al.
Published: (2017-01-01)

Natural Products Targeting Amyloid Beta in Alzheimer’s Disease
by: Joo-Hee Lee, et al.
Published: (2021-02-01)

Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production
by: Ryota Suzuki, et al.
Published: (2023-02-01)