Biological activity reduction and mitochondrial and lysosomal dysfunction of mesenchymal stem cells aging in vitro

Biological activity reduction and mitochondrial and lysosomal dysfunction of mesenchymal stem cells aging in vitro

Abstract Background Mesenchymal stem cells (MSCs) have been extensively used for the treatment of various diseases in preclinical and clinical trials. In vitro propagation is needed to attain enough cells for clinical use. However, cell aging and viability reduction caused by long-time culture have...

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Bibliographic Details
Main Authors: Ge Zhang, Yuli Wang, Jianhua Lin, Bo Wang, Ali Mohsin, Zhimin Cheng, Weijie Hao, Wei-Qiang Gao, Huiming Xu, Meijin Guo
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Stem Cell Research & Therapy
Subjects:
Human umbilical cord mesenchymal stem cells
Cell activity
Mitochondrial dysfunction
Lysosomal dysfunction
Online Access:https://doi.org/10.1186/s13287-022-03107-4

Internet

https://doi.org/10.1186/s13287-022-03107-4

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