Saliva contact during infancy and allergy development in school-age children
Background: Parent-child saliva contact during infancy might stimulate the child’s immune system for effective allergy prevention. However, few studies have investigated its relation to allergy development in school-age children. Objective: We sought to investigate the relationship between parent-ch...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Journal of Allergy and Clinical Immunology: Global |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772829323000334 |
| _version_ | 1797746008271093760 |
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| author | Yoshimi Kubo, DDS, PhD Nobuo Kanazawa, MD, PhD Hironobu Fukuda, MD, PhD Yutaka Inaba, MD, PhD Naoya Mikita, MD, PhD Masatoshi Jinnin, MD, PhD Fukumi Furukawa, MD, PhD Yasushi Kuraishi, PhD Shigemi Yoshihara, MD, PhD |
| author_facet | Yoshimi Kubo, DDS, PhD Nobuo Kanazawa, MD, PhD Hironobu Fukuda, MD, PhD Yutaka Inaba, MD, PhD Naoya Mikita, MD, PhD Masatoshi Jinnin, MD, PhD Fukumi Furukawa, MD, PhD Yasushi Kuraishi, PhD Shigemi Yoshihara, MD, PhD |
| author_sort | Yoshimi Kubo, DDS, PhD |
| collection | DOAJ |
| description | Background: Parent-child saliva contact during infancy might stimulate the child’s immune system for effective allergy prevention. However, few studies have investigated its relation to allergy development in school-age children. Objective: We sought to investigate the relationship between parent-child saliva contact during infancy and allergy development at school age. Methods: We performed a large multicenter cross-sectional study involving Japanese school children and their parents. The self-administered questionnaires including questions from the International Study of Asthma and Allergies in Childhood were distributed to 3570 elementary and junior high school children in 2 local cities. Data were analyzed for the relationship between saliva contact during infancy (age <12 months) and the risk of allergy development, specifically eczema, allergic rhinitis, and asthma. For detailed Methods, please see the Methods section in this article’s Online Repository at www.jacionline.org. Results: The valid response rate was 94.7%. The mean and median age of children was 10.8 ± 2.7 and 11 (interquartile range, 9-13) years, respectively. Saliva contact via sharing eating utensils during infancy was significantly associated with a lower risk of eczema (odds ratio, 0.53; 95% CI, 0.34-0.83) at school age. Saliva contact via parental sucking of pacifiers was significantly associated with a lower risk of eczema (odds ratio, 0.24; 95% CI, 0.10-0.60) and allergic rhinitis (odds ratio, 0.33; 95% CI, 0.15-0.73), and had a borderline association with the risk of asthma in school-age children. Conclusions: Saliva contact during infancy may reduce the risk of developing eczema and allergic rhinitis in school-age children. |
| first_indexed | 2024-03-12T15:30:58Z |
| format | Article |
| id | doaj.art-e54def3229fc469e8e2aab400a38f040 |
| institution | Directory Open Access Journal |
| issn | 2772-8293 |
| language | English |
| last_indexed | 2024-03-12T15:30:58Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Allergy and Clinical Immunology: Global |
| spelling | doaj.art-e54def3229fc469e8e2aab400a38f0402023-08-10T04:35:09ZengElsevierJournal of Allergy and Clinical Immunology: Global2772-82932023-08-0123100108Saliva contact during infancy and allergy development in school-age childrenYoshimi Kubo, DDS, PhD0Nobuo Kanazawa, MD, PhD1Hironobu Fukuda, MD, PhD2Yutaka Inaba, MD, PhD3Naoya Mikita, MD, PhD4Masatoshi Jinnin, MD, PhD5Fukumi Furukawa, MD, PhD6Yasushi Kuraishi, PhD7Shigemi Yoshihara, MD, PhD8Department of Dermatology, Wakayama Medical University, Kimiidera, Wakayama, Japan; Corresponding author: Yoshimi Kubo, DDS, PhD, Department of Dermatology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan.Department of Dermatology, Wakayama Medical University, Kimiidera, Wakayama, Japan; Department of Dermatology, Hyogo Medical University, Mukogawa, Nishinomiya, Hyogo, JapanDepartment of Pediatrics, Dokkyo Medical University, Kitakobayashi, Mibu, Shimotsuga, Tochigi, Japan; Nasu Kids Clinic, Kutsugake, Nasushiobara, Tochigi, JapanDepartment of Dermatology, Wakayama Medical University, Kimiidera, Wakayama, JapanDepartment of Dermatology, Wakayama Medical University, Kimiidera, Wakayama, JapanDepartment of Dermatology, Wakayama Medical University, Kimiidera, Wakayama, JapanDepartment of Dermatology, Wakayama Medical University, Kimiidera, Wakayama, Japan; Department of Dermatology, Takatsuki Red Cross Hospital, Abuno, Takatsuki, Osaka, JapanUniversity Research Administration, Wakayama Medical University, Kimiidera, Wakayama, JapanDepartment of Pediatrics, Dokkyo Medical University, Kitakobayashi, Mibu, Shimotsuga, Tochigi, JapanBackground: Parent-child saliva contact during infancy might stimulate the child’s immune system for effective allergy prevention. However, few studies have investigated its relation to allergy development in school-age children. Objective: We sought to investigate the relationship between parent-child saliva contact during infancy and allergy development at school age. Methods: We performed a large multicenter cross-sectional study involving Japanese school children and their parents. The self-administered questionnaires including questions from the International Study of Asthma and Allergies in Childhood were distributed to 3570 elementary and junior high school children in 2 local cities. Data were analyzed for the relationship between saliva contact during infancy (age <12 months) and the risk of allergy development, specifically eczema, allergic rhinitis, and asthma. For detailed Methods, please see the Methods section in this article’s Online Repository at www.jacionline.org. Results: The valid response rate was 94.7%. The mean and median age of children was 10.8 ± 2.7 and 11 (interquartile range, 9-13) years, respectively. Saliva contact via sharing eating utensils during infancy was significantly associated with a lower risk of eczema (odds ratio, 0.53; 95% CI, 0.34-0.83) at school age. Saliva contact via parental sucking of pacifiers was significantly associated with a lower risk of eczema (odds ratio, 0.24; 95% CI, 0.10-0.60) and allergic rhinitis (odds ratio, 0.33; 95% CI, 0.15-0.73), and had a borderline association with the risk of asthma in school-age children. Conclusions: Saliva contact during infancy may reduce the risk of developing eczema and allergic rhinitis in school-age children.http://www.sciencedirect.com/science/article/pii/S2772829323000334Allergyeczemaallergic rhinitissaliva contacteating utensilspacifier |
| spellingShingle | Yoshimi Kubo, DDS, PhD Nobuo Kanazawa, MD, PhD Hironobu Fukuda, MD, PhD Yutaka Inaba, MD, PhD Naoya Mikita, MD, PhD Masatoshi Jinnin, MD, PhD Fukumi Furukawa, MD, PhD Yasushi Kuraishi, PhD Shigemi Yoshihara, MD, PhD Saliva contact during infancy and allergy development in school-age children Journal of Allergy and Clinical Immunology: Global Allergy eczema allergic rhinitis saliva contact eating utensils pacifier |
| title | Saliva contact during infancy and allergy development in school-age children |
| title_full | Saliva contact during infancy and allergy development in school-age children |
| title_fullStr | Saliva contact during infancy and allergy development in school-age children |
| title_full_unstemmed | Saliva contact during infancy and allergy development in school-age children |
| title_short | Saliva contact during infancy and allergy development in school-age children |
| title_sort | saliva contact during infancy and allergy development in school age children |
| topic | Allergy eczema allergic rhinitis saliva contact eating utensils pacifier |
| url | http://www.sciencedirect.com/science/article/pii/S2772829323000334 |
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