HIV-1 Nucleocapsid Protein Binds Double-Stranded DNA in Multiple Modes to Regulate Compaction and Capsid Uncoating

HIV-1 Nucleocapsid Protein Binds Double-Stranded DNA in Multiple Modes to Regulate Compaction and Capsid Uncoating

The HIV-1 nucleocapsid protein (NC) is a multi-functional protein necessary for viral replication. Recent studies have demonstrated reverse transcription occurs inside the fully intact viral capsid and that the timing of reverse transcription and uncoating are correlated. How a nearly 10 kbp viral D...

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Bibliographic Details
Main Authors: Helena Gien, Michael Morse, Micah J. McCauley, Jonathan P. Kitzrow, Karin Musier-Forsyth, Robert J. Gorelick, Ioulia Rouzina, Mark C. Williams
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Viruses
Subjects:
DNA condensation
optical tweezers
atomic force microscopy
capsid uncoating
HIV-1 nucleocapsid protein
Online Access:https://www.mdpi.com/1999-4915/14/2/235

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