Targeting apoptosis signaling pathways for anticancer therapy
Treatment approaches for cancer, for example chemotherapy, radiotherapy or immunotherapy, primarily act by inducing cell death in cancer cells. Consequently, the inability to trigger cell death pathways or alternatively, evasion of cancer cells to the induction of cell death pathways can result in r...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2011-08-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00023/full |
| _version_ | 1818651991409164288 |
|---|---|
| author | Simone eFulda |
| author_facet | Simone eFulda |
| author_sort | Simone eFulda |
| collection | DOAJ |
| description | Treatment approaches for cancer, for example chemotherapy, radiotherapy or immunotherapy, primarily act by inducing cell death in cancer cells. Consequently, the inability to trigger cell death pathways or alternatively, evasion of cancer cells to the induction of cell death pathways can result in resistance of cancers to current treatment protocols. Therefore, in order to overcome treatment resistance a better understanding of the underlying mechanisms that regulate cell death and survival pathways in cancers and in response to cancer therapy is necessary to develop molecular-targeted therapies. This strategy should lead to more effective and individualized treatment strategies that selectively target deregulated signaling pathways in a tumor type- and patient-specific manner. |
| first_indexed | 2024-12-17T02:14:54Z |
| format | Article |
| id | doaj.art-e54fcbf0c9784e55926b8f76d8089d9c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-17T02:14:54Z |
| publishDate | 2011-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e54fcbf0c9784e55926b8f76d8089d9c2022-12-21T22:07:26ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2011-08-01110.3389/fonc.2011.0002312543Targeting apoptosis signaling pathways for anticancer therapySimone eFulda0Goethe-University FrankfurtTreatment approaches for cancer, for example chemotherapy, radiotherapy or immunotherapy, primarily act by inducing cell death in cancer cells. Consequently, the inability to trigger cell death pathways or alternatively, evasion of cancer cells to the induction of cell death pathways can result in resistance of cancers to current treatment protocols. Therefore, in order to overcome treatment resistance a better understanding of the underlying mechanisms that regulate cell death and survival pathways in cancers and in response to cancer therapy is necessary to develop molecular-targeted therapies. This strategy should lead to more effective and individualized treatment strategies that selectively target deregulated signaling pathways in a tumor type- and patient-specific manner.http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00023/fullApoptosisCancersignaling |
| spellingShingle | Simone eFulda Targeting apoptosis signaling pathways for anticancer therapy Frontiers in Oncology Apoptosis Cancer signaling |
| title | Targeting apoptosis signaling pathways for anticancer therapy |
| title_full | Targeting apoptosis signaling pathways for anticancer therapy |
| title_fullStr | Targeting apoptosis signaling pathways for anticancer therapy |
| title_full_unstemmed | Targeting apoptosis signaling pathways for anticancer therapy |
| title_short | Targeting apoptosis signaling pathways for anticancer therapy |
| title_sort | targeting apoptosis signaling pathways for anticancer therapy |
| topic | Apoptosis Cancer signaling |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00023/full |
| work_keys_str_mv | AT simoneefulda targetingapoptosissignalingpathwaysforanticancertherapy |