Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma
Mature B-cell non-Hodgkin lymphoma (B-NHL) constitutes a group of heterogeneous malignant lymphoproliferative diseases ranging from indolent to highly aggressive forms. Although the survival after chemo-immunotherapy treatment of mature B-NHL has increased over the last years, many patients relapse...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/2/396 |
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| author | Estíbaliz Tamayo-Orbegozo Laura Amo Javier Díez-García Elena Amutio Marta Riñón Marta Alonso Paula Arana Natalia Maruri Susana Larrucea |
| author_facet | Estíbaliz Tamayo-Orbegozo Laura Amo Javier Díez-García Elena Amutio Marta Riñón Marta Alonso Paula Arana Natalia Maruri Susana Larrucea |
| author_sort | Estíbaliz Tamayo-Orbegozo |
| collection | DOAJ |
| description | Mature B-cell non-Hodgkin lymphoma (B-NHL) constitutes a group of heterogeneous malignant lymphoproliferative diseases ranging from indolent to highly aggressive forms. Although the survival after chemo-immunotherapy treatment of mature B-NHL has increased over the last years, many patients relapse or remain refractory due to drug resistance, presenting an unfavorable prognosis. Hence, there is an urgent need to identify new prognostic markers and therapeutic targets. Podocalyxin (PODXL), a sialomucin overexpressed in a variety of tumor cell types and associated with their aggressiveness, has been implicated in multiple aspects of cancer progression, although its participation in hematological malignancies remains unexplored. New evidence points to a role for PODXL in mature B-NHL cell proliferation, survival, migration, drug resistance, and metabolic reprogramming, as well as enhanced levels of PODXL in mature B-NHL. Here, we review the current knowledge on the contribution of PODXL to tumorigenesis, highlighting and discussing its role in mature B-NHL progression. |
| first_indexed | 2024-03-12T10:04:55Z |
| format | Article |
| id | doaj.art-e54fd8792a8e4c82824e12f6bc1a8ab6 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T10:04:55Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e54fd8792a8e4c82824e12f6bc1a8ab62023-09-02T11:23:16ZengMDPI AGCancers2072-66942020-02-0112239610.3390/cancers12020396cancers12020396Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin LymphomaEstíbaliz Tamayo-Orbegozo0Laura Amo1Javier Díez-García2Elena Amutio3Marta Riñón4Marta Alonso5Paula Arana6Natalia Maruri7Susana Larrucea8Regulation of the Immune System Group, Biocruces Bizkaia Health Research Institute, Plaza de Cruces 12, 48903 Barakaldo, Bizkaia, SpainRegulation of the Immune System Group, Biocruces Bizkaia Health Research Institute, Plaza de Cruces 12, 48903 Barakaldo, Bizkaia, SpainMicroscopy Facility, Biocruces Bizkaia Health Research Institute, Plaza de Cruces 12, 48903 Barakaldo, Bizkaia, SpainBlood Cancer Group, Biocruces Bizkaia Health Research Institute, Hospital Universitario Cruces, Plaza de Cruces 12, 48903 Barakaldo, Bizkaia, SpainRegulation of the Immune System Group, Biocruces Bizkaia Health Research Institute, Hospital Universitario Cruces, Plaza de Cruces 12, 48903 Barakaldo, Bizkaia, SpainRegulation of the Immune System Group, Biocruces Bizkaia Health Research Institute, Hospital Universitario Cruces, Plaza de Cruces 12, 48903 Barakaldo, Bizkaia, SpainRegulation of the Immune System Group, Biocruces Bizkaia Health Research Institute, Hospital Universitario Cruces, Plaza de Cruces 12, 48903 Barakaldo, Bizkaia, SpainRegulation of the Immune System Group, Biocruces Bizkaia Health Research Institute, Hospital Universitario Cruces, Plaza de Cruces 12, 48903 Barakaldo, Bizkaia, SpainRegulation of the Immune System Group, Biocruces Bizkaia Health Research Institute, Hospital Universitario Cruces, Plaza de Cruces 12, 48903 Barakaldo, Bizkaia, SpainMature B-cell non-Hodgkin lymphoma (B-NHL) constitutes a group of heterogeneous malignant lymphoproliferative diseases ranging from indolent to highly aggressive forms. Although the survival after chemo-immunotherapy treatment of mature B-NHL has increased over the last years, many patients relapse or remain refractory due to drug resistance, presenting an unfavorable prognosis. Hence, there is an urgent need to identify new prognostic markers and therapeutic targets. Podocalyxin (PODXL), a sialomucin overexpressed in a variety of tumor cell types and associated with their aggressiveness, has been implicated in multiple aspects of cancer progression, although its participation in hematological malignancies remains unexplored. New evidence points to a role for PODXL in mature B-NHL cell proliferation, survival, migration, drug resistance, and metabolic reprogramming, as well as enhanced levels of PODXL in mature B-NHL. Here, we review the current knowledge on the contribution of PODXL to tumorigenesis, highlighting and discussing its role in mature B-NHL progression.https://www.mdpi.com/2072-6694/12/2/396podocalyxinb-cell non-hodgkin lymphomacancer progressionmetastasisdrug resistancemetabolic reprogramming |
| spellingShingle | Estíbaliz Tamayo-Orbegozo Laura Amo Javier Díez-García Elena Amutio Marta Riñón Marta Alonso Paula Arana Natalia Maruri Susana Larrucea Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma Cancers podocalyxin b-cell non-hodgkin lymphoma cancer progression metastasis drug resistance metabolic reprogramming |
| title | Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma |
| title_full | Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma |
| title_fullStr | Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma |
| title_full_unstemmed | Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma |
| title_short | Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma |
| title_sort | emerging role of podocalyxin in the progression of mature b cell non hodgkin lymphoma |
| topic | podocalyxin b-cell non-hodgkin lymphoma cancer progression metastasis drug resistance metabolic reprogramming |
| url | https://www.mdpi.com/2072-6694/12/2/396 |
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