Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology
Abstract Cancer is a major threat to human health. Among various treatment methods, precision therapy has received significant attention since the inception, due to its ability to efficiently inhibit tumor growth, while curtailing common shortcomings from conventional cancer treatment, leading towar...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-11-01
|
| Series: | Signal Transduction and Targeted Therapy |
| Online Access: | https://doi.org/10.1038/s41392-022-01243-0 |
| _version_ | 1797983944417738752 |
|---|---|
| author | Jingjing Yang Anthony Griffin Zhe Qiang Jie Ren |
| author_facet | Jingjing Yang Anthony Griffin Zhe Qiang Jie Ren |
| author_sort | Jingjing Yang |
| collection | DOAJ |
| description | Abstract Cancer is a major threat to human health. Among various treatment methods, precision therapy has received significant attention since the inception, due to its ability to efficiently inhibit tumor growth, while curtailing common shortcomings from conventional cancer treatment, leading towards enhanced survival rates. Particularly, organelle-targeted strategies enable precise accumulation of therapeutic agents in organelles, locally triggering organelle-mediated cell death signals which can greatly reduce the therapeutic threshold dosage and minimize side-effects. In this review, we comprehensively discuss history and recent advances in targeted therapies on organelles, specifically including nucleus, mitochondria, lysosomes and endoplasmic reticulum, while focusing on organelle structures, organelle-mediated cell death signal pathways, and design guidelines of organelle-targeted nanomedicines based on intervention mechanisms. Furthermore, a perspective on future research and clinical opportunities and potential challenges in precision oncology is presented. Through demonstrating recent developments in organelle-targeted therapies, we believe this article can further stimulate broader interests in multidisciplinary research and technology development for enabling advanced organelle-targeted nanomedicines and their corresponding clinic translations. |
| first_indexed | 2024-04-11T06:55:06Z |
| format | Article |
| id | doaj.art-e5501bef0e5244d2807cd4b1e1459eb8 |
| institution | Directory Open Access Journal |
| issn | 2059-3635 |
| language | English |
| last_indexed | 2024-04-11T06:55:06Z |
| publishDate | 2022-11-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Signal Transduction and Targeted Therapy |
| spelling | doaj.art-e5501bef0e5244d2807cd4b1e1459eb82022-12-22T04:39:04ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352022-11-017112710.1038/s41392-022-01243-0Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncologyJingjing Yang0Anthony Griffin1Zhe Qiang2Jie Ren3Institute of Nano and Biopolymeric Materials, School of Materials Science and Engineering, Tongji UniversitySchool of Polymer Science and Engineering, University of Southern MississippiSchool of Polymer Science and Engineering, University of Southern MississippiInstitute of Nano and Biopolymeric Materials, School of Materials Science and Engineering, Tongji UniversityAbstract Cancer is a major threat to human health. Among various treatment methods, precision therapy has received significant attention since the inception, due to its ability to efficiently inhibit tumor growth, while curtailing common shortcomings from conventional cancer treatment, leading towards enhanced survival rates. Particularly, organelle-targeted strategies enable precise accumulation of therapeutic agents in organelles, locally triggering organelle-mediated cell death signals which can greatly reduce the therapeutic threshold dosage and minimize side-effects. In this review, we comprehensively discuss history and recent advances in targeted therapies on organelles, specifically including nucleus, mitochondria, lysosomes and endoplasmic reticulum, while focusing on organelle structures, organelle-mediated cell death signal pathways, and design guidelines of organelle-targeted nanomedicines based on intervention mechanisms. Furthermore, a perspective on future research and clinical opportunities and potential challenges in precision oncology is presented. Through demonstrating recent developments in organelle-targeted therapies, we believe this article can further stimulate broader interests in multidisciplinary research and technology development for enabling advanced organelle-targeted nanomedicines and their corresponding clinic translations.https://doi.org/10.1038/s41392-022-01243-0 |
| spellingShingle | Jingjing Yang Anthony Griffin Zhe Qiang Jie Ren Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology Signal Transduction and Targeted Therapy |
| title | Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology |
| title_full | Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology |
| title_fullStr | Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology |
| title_full_unstemmed | Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology |
| title_short | Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology |
| title_sort | organelle targeted therapies a comprehensive review on system design for enabling precision oncology |
| url | https://doi.org/10.1038/s41392-022-01243-0 |
| work_keys_str_mv | AT jingjingyang organelletargetedtherapiesacomprehensivereviewonsystemdesignforenablingprecisiononcology AT anthonygriffin organelletargetedtherapiesacomprehensivereviewonsystemdesignforenablingprecisiononcology AT zheqiang organelletargetedtherapiesacomprehensivereviewonsystemdesignforenablingprecisiononcology AT jieren organelletargetedtherapiesacomprehensivereviewonsystemdesignforenablingprecisiononcology |