Cell-cycle-gated feedback control mediates desensitization to interferon stimulation
Cells use molecular circuits to interpret and respond to extracellular cues, such as hormones and cytokines, which are often released in a temporally varying fashion. In this study, we combine microfluidics, time-lapse microscopy, and computational modeling to investigate how the type I interferon (...
Main Authors: | Anusorn Mudla, Yanfei Jiang, Kei-ichiro Arimoto, Bingxian Xu, Adarsh Rajesh, Andy P Ryan, Wei Wang, Matthew D Daugherty, Dong-Er Zhang, Nan Hao |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-09-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/58825 |
Similar Items
-
Distinct transcriptomic and metabolomic profiles characterize NSAID-induced urticaria/angioedema patients undergoing aspirin desensitization
by: Tay, Sen Hee, et al.
Published: (2023) -
Desensitization to allopurinol in patients with gout and cutaneous reactions /
by: Fam, Adel G. -
Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel
by: Ailing Tong, et al.
Published: (2019-11-01) -
Clofarabine desensitization: A case report
by: Sarah M. Hayes, et al.
Published: (2017-01-01) -
Case report: Insulin desensitization as the only option for managing insulin allergy in a Sudanese patient
by: Rihan Said, et al.
Published: (2023-05-01)