Delayed PCI is not beneficial for STEMI patients with impaired renal function: a retrospective cohort study
Abstract Background Preexisting impaired renal function (IRF) and contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) are important prognostic parameters, but it is unknown whether delayed PCI is still...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-023-03271-2 |
| _version_ | 1827943626535075840 |
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| author | Yi Lao Kaitong Chen Li Feng Yong Yuan Jin Zhang Liting Zhang Xuansheng Huang Mingxing Li Zidi Wu Jianping Bin Yulin Liao |
| author_facet | Yi Lao Kaitong Chen Li Feng Yong Yuan Jin Zhang Liting Zhang Xuansheng Huang Mingxing Li Zidi Wu Jianping Bin Yulin Liao |
| author_sort | Yi Lao |
| collection | DOAJ |
| description | Abstract Background Preexisting impaired renal function (IRF) and contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) are important prognostic parameters, but it is unknown whether delayed PCI is still beneficial for STEMI patients with IRF. Methods A retrospective single-center cohort study was performed in 164 patients who presented at least 12 h after symptom onset, and were diagnosed with STEMI and IRF. They were assigned to two groups to receive PCI plus optimal medical therapy (OMT) and OMT alone respectively. Clinical outcomes at 30 days and 1 year were compared between two groups, and hazard ratio for survival was analyzed using Cox regression model. A power analysis demanded 34 patients in each group to produce a power of 90% and a P value of 0.05. Results The 30-day mortality was significantly lower in PCI group (n = 126) than in non-PCI group (n = 38) (11.1% versus 28.9%, P = 0.018), while there was no significant difference in the 1-year mortality and incidence of cardiovascular comorbidities between the two groups. Cox regression analysis showed that patients with IRF didn’t benefit from receiving PCI on survival rate (P = 0.267). Conclusions Delayed PCI is not beneficial on one-year clinical outcomes for STEMI patients with IRF. |
| first_indexed | 2024-03-13T10:18:16Z |
| format | Article |
| id | doaj.art-e552168175914fa39e9f07c877c2e80d |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-03-13T10:18:16Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-e552168175914fa39e9f07c877c2e80d2023-05-21T11:08:02ZengBMCBMC Cardiovascular Disorders1471-22612023-05-012311710.1186/s12872-023-03271-2Delayed PCI is not beneficial for STEMI patients with impaired renal function: a retrospective cohort studyYi Lao0Kaitong Chen1Li Feng2Yong Yuan3Jin Zhang4Liting Zhang5Xuansheng Huang6Mingxing Li7Zidi Wu8Jianping Bin9Yulin Liao10Department of Cardiology, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Heart Function and Microcirculation, Nanfang Hospital, Southern Medical UniversityCardiovascular Department, The First Affiliated Hospital of Guangdong Pharmaceutical UniversityDepartment of Cardiology, Zhongshan Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Zhongshan Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Zhongshan Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Zhongshan Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Zhongshan Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Zhongshan Hospital, Sun Yat-sen UniversityDepartment of Cardiology, Zhongshan Hospital, Sun Yat-sen UniversityDepartment of Cardiology, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Heart Function and Microcirculation, Nanfang Hospital, Southern Medical UniversityDepartment of Cardiology, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Heart Function and Microcirculation, Nanfang Hospital, Southern Medical UniversityAbstract Background Preexisting impaired renal function (IRF) and contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) are important prognostic parameters, but it is unknown whether delayed PCI is still beneficial for STEMI patients with IRF. Methods A retrospective single-center cohort study was performed in 164 patients who presented at least 12 h after symptom onset, and were diagnosed with STEMI and IRF. They were assigned to two groups to receive PCI plus optimal medical therapy (OMT) and OMT alone respectively. Clinical outcomes at 30 days and 1 year were compared between two groups, and hazard ratio for survival was analyzed using Cox regression model. A power analysis demanded 34 patients in each group to produce a power of 90% and a P value of 0.05. Results The 30-day mortality was significantly lower in PCI group (n = 126) than in non-PCI group (n = 38) (11.1% versus 28.9%, P = 0.018), while there was no significant difference in the 1-year mortality and incidence of cardiovascular comorbidities between the two groups. Cox regression analysis showed that patients with IRF didn’t benefit from receiving PCI on survival rate (P = 0.267). Conclusions Delayed PCI is not beneficial on one-year clinical outcomes for STEMI patients with IRF.https://doi.org/10.1186/s12872-023-03271-2Acute myocardial infarctionPercutaneous coronary interventionLate reperfusionRenal function |
| spellingShingle | Yi Lao Kaitong Chen Li Feng Yong Yuan Jin Zhang Liting Zhang Xuansheng Huang Mingxing Li Zidi Wu Jianping Bin Yulin Liao Delayed PCI is not beneficial for STEMI patients with impaired renal function: a retrospective cohort study BMC Cardiovascular Disorders Acute myocardial infarction Percutaneous coronary intervention Late reperfusion Renal function |
| title | Delayed PCI is not beneficial for STEMI patients with impaired renal function: a retrospective cohort study |
| title_full | Delayed PCI is not beneficial for STEMI patients with impaired renal function: a retrospective cohort study |
| title_fullStr | Delayed PCI is not beneficial for STEMI patients with impaired renal function: a retrospective cohort study |
| title_full_unstemmed | Delayed PCI is not beneficial for STEMI patients with impaired renal function: a retrospective cohort study |
| title_short | Delayed PCI is not beneficial for STEMI patients with impaired renal function: a retrospective cohort study |
| title_sort | delayed pci is not beneficial for stemi patients with impaired renal function a retrospective cohort study |
| topic | Acute myocardial infarction Percutaneous coronary intervention Late reperfusion Renal function |
| url | https://doi.org/10.1186/s12872-023-03271-2 |
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