(Hetero)aryl substituted thiazol-2,4-yl scaffold as human carbonic anhydrase I, II, VII and XIV activators

(Hetero)aryl substituted thiazol-2,4-yl scaffold as human carbonic anhydrase I, II, VII and XIV activators

Using histamine as lead molecule, a library of (hetero)aryl substituted thiazol-2,4-yl derivatives incorporating pyridine as proton shuttling moiety were obtained and investigated as activators of human carbonic anhydrase (CA, EC 4.2.1.1) isoforms I, II, VII and XIV. Some derivatives displayed good...

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Bibliographic Details
Main Authors: Marouan Rami, Jean-Yves Winum, Claudiu T. Supuran, Patricia Melnyk, Saïd Yous
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
thiazole scaffold
carbonic anhydrase activators
isozymes
drug design
synthesis
Online Access:http://dx.doi.org/10.1080/14756366.2018.1543292

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