Insights into Diphthamide, Key Diphtheria Toxin Effector
Diphtheria toxin (DT) inhibits eukaryotic translation elongation factor 2 (eEF2) by ADP-ribosylation in a fashion that requires diphthamide, a modified histidine residue on eEF2. In budding yeast, diphthamide formation involves seven genes, DPH1-DPH7. In an effort to further study diphthamide synthe...
Main Authors: | Raffael Schaffrath, Michael J. R. Stark, Shanow Uthman, Viktor Scheidt, Wael Abdel-Fattah |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2013-05-01
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Series: | Toxins |
Subjects: | |
Online Access: | http://www.mdpi.com/2072-6651/5/5/958 |
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