Basilar artery plaque distribution is associated with pontine infarction and vertebrobasilar artery geometry
BackgroundBasilar artery (BA) atherosclerosis is a common cause of posterior-circulation ischemic stroke. In this study, we investigate the relationship between BA plaque distribution and pontine infarction (PI), further, explore the influence of vertebrobasilar artery (VBA) geometries on BA plaque...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1079905/full |
| _version_ | 1827992518014271488 |
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| author | Jinmei Zheng Bin Sun Ruolan Lin Yongqi Teng Enshuang Zheng Xihai Zhao Yunjing Xue |
| author_facet | Jinmei Zheng Bin Sun Ruolan Lin Yongqi Teng Enshuang Zheng Xihai Zhao Yunjing Xue |
| author_sort | Jinmei Zheng |
| collection | DOAJ |
| description | BackgroundBasilar artery (BA) atherosclerosis is a common cause of posterior-circulation ischemic stroke. In this study, we investigate the relationship between BA plaque distribution and pontine infarction (PI), further, explore the influence of vertebrobasilar artery (VBA) geometries on BA plaque distribution.Materials and methods303 patients were performed with MRI in this study, patients were divided into three groups: no cerebral infarction (NCI), anterior circulation cerebral infarction (ACCI), and posterior circulation cerebral infarction (PCCI), the VBA geometry was classified into four configurations: Walking, Tuning Fork, Lambda, and No Confluence. The AP-Mid-BA, Lateral-Mid-BA, and VA-BA angles were measured on three-dimensional time-of-flight magnetic resonance angiography. Patients underwent high-resolution magnetic resonance imaging to evaluate the BA plaque distribution (either anterior, posterior, or lateral wall). Acute and subacute cerebral infarction [including pontine infarction (PI)] were identified by T2 weighted imaging-fluid-attenuated inversion recovery and diffusion-weighted imaging.ResultsThe presence of BA plaque (P < 0.001) were associated with PCCI. Eighty-six patients all with BA plaque were further analyzed, compared with patients without pontine infarction, patients with pontine infarction were more likely to have plaque distributed at the posterior wall (P = 0.009) and have larger VA-BA anger (38.72° ± 26.01° vs. 26.59° ± 17.33°, P = 0.035). BA plaques in patients with pontine infarction were more frequently located at the posterior wall (50.00%) than at the anterior (10.00%) and lateral (37.50%) walls (P = 0.028). In Walking, Lambda and No Confluence geometry, BA plaques were prone to located at the lateral wall than at the anterior and posterior walls (all P ≤ 0.05). In the Tuning Fork group, BA plaques were evenly distributed.ConclusionBA plaque was related to PCCI, BA plaque distribution was associated with PI, and VBA configuration strongly influences BA plaque distribution. |
| first_indexed | 2024-04-10T04:05:32Z |
| format | Article |
| id | doaj.art-e55732fd755c4ae2a7546f2547189312 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T04:05:32Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-e55732fd755c4ae2a7546f25471893122023-03-13T06:27:09ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-03-011410.3389/fneur.2023.10799051079905Basilar artery plaque distribution is associated with pontine infarction and vertebrobasilar artery geometryJinmei Zheng0Bin Sun1Ruolan Lin2Yongqi Teng3Enshuang Zheng4Xihai Zhao5Yunjing Xue6Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaDepartment of Radiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaDepartment of Radiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaDepartment of Radiology, Changle District Hospital of Fuzhou, Fuzhou, Fujian, ChinaDepartment of Radiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaDepartment of Biomedical Engineering, Center for Biomedical Imaging Research, Tsinghua University School of Medicine, Beijing, ChinaDepartment of Radiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaBackgroundBasilar artery (BA) atherosclerosis is a common cause of posterior-circulation ischemic stroke. In this study, we investigate the relationship between BA plaque distribution and pontine infarction (PI), further, explore the influence of vertebrobasilar artery (VBA) geometries on BA plaque distribution.Materials and methods303 patients were performed with MRI in this study, patients were divided into three groups: no cerebral infarction (NCI), anterior circulation cerebral infarction (ACCI), and posterior circulation cerebral infarction (PCCI), the VBA geometry was classified into four configurations: Walking, Tuning Fork, Lambda, and No Confluence. The AP-Mid-BA, Lateral-Mid-BA, and VA-BA angles were measured on three-dimensional time-of-flight magnetic resonance angiography. Patients underwent high-resolution magnetic resonance imaging to evaluate the BA plaque distribution (either anterior, posterior, or lateral wall). Acute and subacute cerebral infarction [including pontine infarction (PI)] were identified by T2 weighted imaging-fluid-attenuated inversion recovery and diffusion-weighted imaging.ResultsThe presence of BA plaque (P < 0.001) were associated with PCCI. Eighty-six patients all with BA plaque were further analyzed, compared with patients without pontine infarction, patients with pontine infarction were more likely to have plaque distributed at the posterior wall (P = 0.009) and have larger VA-BA anger (38.72° ± 26.01° vs. 26.59° ± 17.33°, P = 0.035). BA plaques in patients with pontine infarction were more frequently located at the posterior wall (50.00%) than at the anterior (10.00%) and lateral (37.50%) walls (P = 0.028). In Walking, Lambda and No Confluence geometry, BA plaques were prone to located at the lateral wall than at the anterior and posterior walls (all P ≤ 0.05). In the Tuning Fork group, BA plaques were evenly distributed.ConclusionBA plaque was related to PCCI, BA plaque distribution was associated with PI, and VBA configuration strongly influences BA plaque distribution.https://www.frontiersin.org/articles/10.3389/fneur.2023.1079905/fullbasilar artery atherosclerosisplaque distributionpontine infarctionvertebrobasilar arterygeometry |
| spellingShingle | Jinmei Zheng Bin Sun Ruolan Lin Yongqi Teng Enshuang Zheng Xihai Zhao Yunjing Xue Basilar artery plaque distribution is associated with pontine infarction and vertebrobasilar artery geometry Frontiers in Neurology basilar artery atherosclerosis plaque distribution pontine infarction vertebrobasilar artery geometry |
| title | Basilar artery plaque distribution is associated with pontine infarction and vertebrobasilar artery geometry |
| title_full | Basilar artery plaque distribution is associated with pontine infarction and vertebrobasilar artery geometry |
| title_fullStr | Basilar artery plaque distribution is associated with pontine infarction and vertebrobasilar artery geometry |
| title_full_unstemmed | Basilar artery plaque distribution is associated with pontine infarction and vertebrobasilar artery geometry |
| title_short | Basilar artery plaque distribution is associated with pontine infarction and vertebrobasilar artery geometry |
| title_sort | basilar artery plaque distribution is associated with pontine infarction and vertebrobasilar artery geometry |
| topic | basilar artery atherosclerosis plaque distribution pontine infarction vertebrobasilar artery geometry |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1079905/full |
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