Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain
Neuropathic pain (NP) is a complex, debilitating, chronic pain state, heterogeneous in nature and caused by a lesion or disease affecting the somatosensory system. Its pathogenesis involves a wide range of molecular pathways. NP treatment is extremely challenging, due to its complex underlying disea...
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MDPI AG
2021-05-01
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author | Hari Prasad Joshi Hyun-Jung Jo Yong-Ho Kim Seong-Bae An Chul-Kyu Park Inbo Han |
author_facet | Hari Prasad Joshi Hyun-Jung Jo Yong-Ho Kim Seong-Bae An Chul-Kyu Park Inbo Han |
author_sort | Hari Prasad Joshi |
collection | DOAJ |
description | Neuropathic pain (NP) is a complex, debilitating, chronic pain state, heterogeneous in nature and caused by a lesion or disease affecting the somatosensory system. Its pathogenesis involves a wide range of molecular pathways. NP treatment is extremely challenging, due to its complex underlying disease mechanisms. Current pharmacological and nonpharmacological approaches can provide long-lasting pain relief to a limited percentage of patients and lack safe and effective treatment options. Therefore, scientists are focusing on the introduction of novel treatment approaches, such as stem cell therapy. A growing number of reports have highlighted the potential of stem cells for treating NP. In this review, we briefly introduce NP, current pharmacological and nonpharmacological treatments, and preclinical studies of stem cells to treat NP. In addition, we summarize stem cell mechanisms—including neuromodulation in treating NP. Literature searches were conducted using PubMed to provide an overview of the neuroprotective effects of stem cells with particular emphasis on recent translational research regarding stem cell-based treatment of NP, highlighting its potential as a novel therapeutic approach. |
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id | doaj.art-e559ac74a16f488b91d02da63a9f6799 |
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issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-10T11:43:50Z |
publishDate | 2021-05-01 |
publisher | MDPI AG |
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series | International Journal of Molecular Sciences |
spelling | doaj.art-e559ac74a16f488b91d02da63a9f67992023-11-21T18:18:13ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-01229485310.3390/ijms22094853Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic PainHari Prasad Joshi0Hyun-Jung Jo1Yong-Ho Kim2Seong-Bae An3Chul-Kyu Park4Inbo Han5Department of Neurosurgery, School of Medicine, CHA University, CHA Bundang Medical Center, Seongnam-si 13496, Gyeonggi-do, KoreaGachon Pain Center, Department of Physiology, College of Medicine, Gachon University, Incheon 21999, Gyeonggi-do, KoreaGachon Pain Center, Department of Physiology, College of Medicine, Gachon University, Incheon 21999, Gyeonggi-do, KoreaDepartment of Neurosurgery, School of Medicine, CHA University, CHA Bundang Medical Center, Seongnam-si 13496, Gyeonggi-do, KoreaGachon Pain Center, Department of Physiology, College of Medicine, Gachon University, Incheon 21999, Gyeonggi-do, KoreaDepartment of Neurosurgery, School of Medicine, CHA University, CHA Bundang Medical Center, Seongnam-si 13496, Gyeonggi-do, KoreaNeuropathic pain (NP) is a complex, debilitating, chronic pain state, heterogeneous in nature and caused by a lesion or disease affecting the somatosensory system. Its pathogenesis involves a wide range of molecular pathways. NP treatment is extremely challenging, due to its complex underlying disease mechanisms. Current pharmacological and nonpharmacological approaches can provide long-lasting pain relief to a limited percentage of patients and lack safe and effective treatment options. Therefore, scientists are focusing on the introduction of novel treatment approaches, such as stem cell therapy. A growing number of reports have highlighted the potential of stem cells for treating NP. In this review, we briefly introduce NP, current pharmacological and nonpharmacological treatments, and preclinical studies of stem cells to treat NP. In addition, we summarize stem cell mechanisms—including neuromodulation in treating NP. Literature searches were conducted using PubMed to provide an overview of the neuroprotective effects of stem cells with particular emphasis on recent translational research regarding stem cell-based treatment of NP, highlighting its potential as a novel therapeutic approach.https://www.mdpi.com/1422-0067/22/9/4853mesenchymal stem cellneural stem cellneuropathic painneuroinflammationneuromodulation |
spellingShingle | Hari Prasad Joshi Hyun-Jung Jo Yong-Ho Kim Seong-Bae An Chul-Kyu Park Inbo Han Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain International Journal of Molecular Sciences mesenchymal stem cell neural stem cell neuropathic pain neuroinflammation neuromodulation |
title | Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain |
title_full | Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain |
title_fullStr | Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain |
title_full_unstemmed | Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain |
title_short | Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain |
title_sort | stem cell therapy for modulating neuroinflammation in neuropathic pain |
topic | mesenchymal stem cell neural stem cell neuropathic pain neuroinflammation neuromodulation |
url | https://www.mdpi.com/1422-0067/22/9/4853 |
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