Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain

Neuropathic pain (NP) is a complex, debilitating, chronic pain state, heterogeneous in nature and caused by a lesion or disease affecting the somatosensory system. Its pathogenesis involves a wide range of molecular pathways. NP treatment is extremely challenging, due to its complex underlying disea...

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Main Authors: Hari Prasad Joshi, Hyun-Jung Jo, Yong-Ho Kim, Seong-Bae An, Chul-Kyu Park, Inbo Han
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/22/9/4853
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author Hari Prasad Joshi
Hyun-Jung Jo
Yong-Ho Kim
Seong-Bae An
Chul-Kyu Park
Inbo Han
author_facet Hari Prasad Joshi
Hyun-Jung Jo
Yong-Ho Kim
Seong-Bae An
Chul-Kyu Park
Inbo Han
author_sort Hari Prasad Joshi
collection DOAJ
description Neuropathic pain (NP) is a complex, debilitating, chronic pain state, heterogeneous in nature and caused by a lesion or disease affecting the somatosensory system. Its pathogenesis involves a wide range of molecular pathways. NP treatment is extremely challenging, due to its complex underlying disease mechanisms. Current pharmacological and nonpharmacological approaches can provide long-lasting pain relief to a limited percentage of patients and lack safe and effective treatment options. Therefore, scientists are focusing on the introduction of novel treatment approaches, such as stem cell therapy. A growing number of reports have highlighted the potential of stem cells for treating NP. In this review, we briefly introduce NP, current pharmacological and nonpharmacological treatments, and preclinical studies of stem cells to treat NP. In addition, we summarize stem cell mechanisms—including neuromodulation in treating NP. Literature searches were conducted using PubMed to provide an overview of the neuroprotective effects of stem cells with particular emphasis on recent translational research regarding stem cell-based treatment of NP, highlighting its potential as a novel therapeutic approach.
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spelling doaj.art-e559ac74a16f488b91d02da63a9f67992023-11-21T18:18:13ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-01229485310.3390/ijms22094853Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic PainHari Prasad Joshi0Hyun-Jung Jo1Yong-Ho Kim2Seong-Bae An3Chul-Kyu Park4Inbo Han5Department of Neurosurgery, School of Medicine, CHA University, CHA Bundang Medical Center, Seongnam-si 13496, Gyeonggi-do, KoreaGachon Pain Center, Department of Physiology, College of Medicine, Gachon University, Incheon 21999, Gyeonggi-do, KoreaGachon Pain Center, Department of Physiology, College of Medicine, Gachon University, Incheon 21999, Gyeonggi-do, KoreaDepartment of Neurosurgery, School of Medicine, CHA University, CHA Bundang Medical Center, Seongnam-si 13496, Gyeonggi-do, KoreaGachon Pain Center, Department of Physiology, College of Medicine, Gachon University, Incheon 21999, Gyeonggi-do, KoreaDepartment of Neurosurgery, School of Medicine, CHA University, CHA Bundang Medical Center, Seongnam-si 13496, Gyeonggi-do, KoreaNeuropathic pain (NP) is a complex, debilitating, chronic pain state, heterogeneous in nature and caused by a lesion or disease affecting the somatosensory system. Its pathogenesis involves a wide range of molecular pathways. NP treatment is extremely challenging, due to its complex underlying disease mechanisms. Current pharmacological and nonpharmacological approaches can provide long-lasting pain relief to a limited percentage of patients and lack safe and effective treatment options. Therefore, scientists are focusing on the introduction of novel treatment approaches, such as stem cell therapy. A growing number of reports have highlighted the potential of stem cells for treating NP. In this review, we briefly introduce NP, current pharmacological and nonpharmacological treatments, and preclinical studies of stem cells to treat NP. In addition, we summarize stem cell mechanisms—including neuromodulation in treating NP. Literature searches were conducted using PubMed to provide an overview of the neuroprotective effects of stem cells with particular emphasis on recent translational research regarding stem cell-based treatment of NP, highlighting its potential as a novel therapeutic approach.https://www.mdpi.com/1422-0067/22/9/4853mesenchymal stem cellneural stem cellneuropathic painneuroinflammationneuromodulation
spellingShingle Hari Prasad Joshi
Hyun-Jung Jo
Yong-Ho Kim
Seong-Bae An
Chul-Kyu Park
Inbo Han
Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain
International Journal of Molecular Sciences
mesenchymal stem cell
neural stem cell
neuropathic pain
neuroinflammation
neuromodulation
title Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain
title_full Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain
title_fullStr Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain
title_full_unstemmed Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain
title_short Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain
title_sort stem cell therapy for modulating neuroinflammation in neuropathic pain
topic mesenchymal stem cell
neural stem cell
neuropathic pain
neuroinflammation
neuromodulation
url https://www.mdpi.com/1422-0067/22/9/4853
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AT seongbaean stemcelltherapyformodulatingneuroinflammationinneuropathicpain
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