Epidemiology and antifungal resistance in invasive aspergillosis according to primary disease - review of the literature
<p>Abstract</p> <p>Aspergilli, less susceptible to antifungals emerge and resistance to azoles have been found mainly in <it>Aspergillus fumigatus; </it>this has launched a new phase in handling aspergillosis. Resistant strains have currently been reported from Belgium,...
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| Format: | Article |
| Language: | English |
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BMC
2011-04-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | http://www.eurjmedres.com/content/16/4/153 |
| _version_ | 1818835712046268416 |
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| author | Mayr A Lass-Flörl C |
| author_facet | Mayr A Lass-Flörl C |
| author_sort | Mayr A |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Aspergilli, less susceptible to antifungals emerge and resistance to azoles have been found mainly in <it>Aspergillus fumigatus; </it>this has launched a new phase in handling aspergillosis. Resistant strains have currently been reported from Belgium, Canada, China, Denmark, France, Norway, Spain, Sweden, The Netherlands, UK and the USA. Centres in the UK (Manchester) and The Netherlands (Nijmegen) have described particularly high frequencies (15 and 10% respectively), and a significant increase in azole resistance in recent years. The reason of this high incidence may be due to long term azole therapy in patients with chronic aspergillosis in Manchester, and due to high use of agricultural azoles in Nijmegen. The primary underlying mechanism of resistance is as a result of alterations in the <it>cyp51A </it>target gene, with a variety of mutations found in clinical isolates and one genotype identified in the environmental (LH98). Reports on well documented in vitro and in vivo resistance to echinocandins are rare for <it>Aspergillus </it>species and resistance may be under-diagnosed as susceptibility testing is less frequently performed due to technical reasons.</p> |
| first_indexed | 2024-12-19T02:55:04Z |
| format | Article |
| id | doaj.art-e55a1325839b42ebbd5ac15f1bab1ad8 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-12-19T02:55:04Z |
| publishDate | 2011-04-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-e55a1325839b42ebbd5ac15f1bab1ad82022-12-21T20:38:23ZengBMCEuropean Journal of Medical Research2047-783X2011-04-0116415310.1186/2047-783X-16-4-153Epidemiology and antifungal resistance in invasive aspergillosis according to primary disease - review of the literatureMayr ALass-Flörl C<p>Abstract</p> <p>Aspergilli, less susceptible to antifungals emerge and resistance to azoles have been found mainly in <it>Aspergillus fumigatus; </it>this has launched a new phase in handling aspergillosis. Resistant strains have currently been reported from Belgium, Canada, China, Denmark, France, Norway, Spain, Sweden, The Netherlands, UK and the USA. Centres in the UK (Manchester) and The Netherlands (Nijmegen) have described particularly high frequencies (15 and 10% respectively), and a significant increase in azole resistance in recent years. The reason of this high incidence may be due to long term azole therapy in patients with chronic aspergillosis in Manchester, and due to high use of agricultural azoles in Nijmegen. The primary underlying mechanism of resistance is as a result of alterations in the <it>cyp51A </it>target gene, with a variety of mutations found in clinical isolates and one genotype identified in the environmental (LH98). Reports on well documented in vitro and in vivo resistance to echinocandins are rare for <it>Aspergillus </it>species and resistance may be under-diagnosed as susceptibility testing is less frequently performed due to technical reasons.</p>http://www.eurjmedres.com/content/16/4/153Epidemiologyantifungal resistance<it>Aspergillus </it>azolescandins |
| spellingShingle | Mayr A Lass-Flörl C Epidemiology and antifungal resistance in invasive aspergillosis according to primary disease - review of the literature European Journal of Medical Research Epidemiology antifungal resistance <it>Aspergillus </it> azoles candins |
| title | Epidemiology and antifungal resistance in invasive aspergillosis according to primary disease - review of the literature |
| title_full | Epidemiology and antifungal resistance in invasive aspergillosis according to primary disease - review of the literature |
| title_fullStr | Epidemiology and antifungal resistance in invasive aspergillosis according to primary disease - review of the literature |
| title_full_unstemmed | Epidemiology and antifungal resistance in invasive aspergillosis according to primary disease - review of the literature |
| title_short | Epidemiology and antifungal resistance in invasive aspergillosis according to primary disease - review of the literature |
| title_sort | epidemiology and antifungal resistance in invasive aspergillosis according to primary disease review of the literature |
| topic | Epidemiology antifungal resistance <it>Aspergillus </it> azoles candins |
| url | http://www.eurjmedres.com/content/16/4/153 |
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