Can Conization Specimens Predict Sentinel Lymph Node Status in Early-Stage Cervical Cancer? A SENTICOL Group Study
Background: The prognosis of patients with cervical cancer is significantly worsened in case of lymph node involvement. The goal of this study was to determine whether pathologic features in conization specimens can predict the sentinel lymph node (SLN) status in early-stage cervical cancer. Methods...
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| Format: | Article |
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MDPI AG
2021-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/21/5423 |
| _version_ | 1797512746057596928 |
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| author | Vincent Balaya Benedetta Guani Julie Mereaux Laurent Magaud Basile Pache Hélène Bonsang-Kitzis Charlotte Ngô David Desseauve Patrice Mathevet Fabrice Lécuru on behalf of the SENTICOL Group |
| author_facet | Vincent Balaya Benedetta Guani Julie Mereaux Laurent Magaud Basile Pache Hélène Bonsang-Kitzis Charlotte Ngô David Desseauve Patrice Mathevet Fabrice Lécuru on behalf of the SENTICOL Group |
| author_sort | Vincent Balaya |
| collection | DOAJ |
| description | Background: The prognosis of patients with cervical cancer is significantly worsened in case of lymph node involvement. The goal of this study was to determine whether pathologic features in conization specimens can predict the sentinel lymph node (SLN) status in early-stage cervical cancer. Methods: An ancillary analysis of two prospective multicentric database on SLN biopsy for cervical cancer (SENTICOL I and II) was carried out. Patients with IA to IB2 2018 FIGO stage, who underwent preoperative conization before SLN biopsy were included. Results: Between January 2005 and July 2012, 161 patients from 25 French centers fulfilled the inclusion criteria. Macrometastases, micrometastases and Isolated tumor cells (ITCs) were found in 4 (2.5%), 6 (3.7%) and 5 (3.1%) patients respectively. Compared to negative SLN patients, patients with micrometastatic and macrometastatic SLN were more likely to have lymphovascular space invasion (LVSI) (60% vs. 29.5%, <i>p</i> = 0.04) and deep stromal invasion (DSI) ≥ 10 mm (50% vs. 17.8%, <i>p</i> = 0.04). Among the 93 patients with DSI < 10 mm and absence of LVSI on conization specimens, three patients (3.2%) had ITCs and only one (1.1%) had micrometastases. Conclusions: Patients with DSI < 10 mm and no LVSI in conization specimens had lower risk of micro- and macrometastatic SLN. In this subpopulation, full node dissection may be questionable in case of SLN unilateral detection. |
| first_indexed | 2024-03-10T06:06:02Z |
| format | Article |
| id | doaj.art-e55e382a13524ea297d3274102c4757e |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T06:06:02Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e55e382a13524ea297d3274102c4757e2023-11-22T20:35:02ZengMDPI AGCancers2072-66942021-10-011321542310.3390/cancers13215423Can Conization Specimens Predict Sentinel Lymph Node Status in Early-Stage Cervical Cancer? A SENTICOL Group StudyVincent Balaya0Benedetta Guani1Julie Mereaux2Laurent Magaud3Basile Pache4Hélène Bonsang-Kitzis5Charlotte Ngô6David Desseauve7Patrice Mathevet8Fabrice Lécuru9on behalf of the SENTICOL GroupGynecology Department, Centre Hospitalo-Universitaire Vaudois, 1011 Lausanne, SwitzerlandGynecology Department, Centre Hospitalo-Universitaire Vaudois, 1011 Lausanne, SwitzerlandBreast, Gynecology and Reconstructive Surgery Unit, Curie Institute, 75005 Paris, FranceClinical Research and Epidemiology Department, Public Health Center, Hospices Civils de Lyon, F-69003 Lyon, FranceGynecology Department, Centre Hospitalo-Universitaire Vaudois, 1011 Lausanne, SwitzerlandGynecological and Breast Surgery and Cancerology Center, RAMSAY-Générale de Santé, Hôpital Privé des Peupliers, 75013 Paris, FranceGynecological and Breast Surgery and Cancerology Center, RAMSAY-Générale de Santé, Hôpital Privé des Peupliers, 75013 Paris, FranceGynecology Department, Centre Hospitalo-Universitaire Vaudois, 1011 Lausanne, SwitzerlandGynecology Department, Centre Hospitalo-Universitaire Vaudois, 1011 Lausanne, SwitzerlandBreast, Gynecology and Reconstructive Surgery Unit, Curie Institute, 75005 Paris, FranceBackground: The prognosis of patients with cervical cancer is significantly worsened in case of lymph node involvement. The goal of this study was to determine whether pathologic features in conization specimens can predict the sentinel lymph node (SLN) status in early-stage cervical cancer. Methods: An ancillary analysis of two prospective multicentric database on SLN biopsy for cervical cancer (SENTICOL I and II) was carried out. Patients with IA to IB2 2018 FIGO stage, who underwent preoperative conization before SLN biopsy were included. Results: Between January 2005 and July 2012, 161 patients from 25 French centers fulfilled the inclusion criteria. Macrometastases, micrometastases and Isolated tumor cells (ITCs) were found in 4 (2.5%), 6 (3.7%) and 5 (3.1%) patients respectively. Compared to negative SLN patients, patients with micrometastatic and macrometastatic SLN were more likely to have lymphovascular space invasion (LVSI) (60% vs. 29.5%, <i>p</i> = 0.04) and deep stromal invasion (DSI) ≥ 10 mm (50% vs. 17.8%, <i>p</i> = 0.04). Among the 93 patients with DSI < 10 mm and absence of LVSI on conization specimens, three patients (3.2%) had ITCs and only one (1.1%) had micrometastases. Conclusions: Patients with DSI < 10 mm and no LVSI in conization specimens had lower risk of micro- and macrometastatic SLN. In this subpopulation, full node dissection may be questionable in case of SLN unilateral detection.https://www.mdpi.com/2072-6694/13/21/5423cervical cancersentinel lymph nodeconizationSENTICOLstromal invasionlymphovascular space invasion |
| spellingShingle | Vincent Balaya Benedetta Guani Julie Mereaux Laurent Magaud Basile Pache Hélène Bonsang-Kitzis Charlotte Ngô David Desseauve Patrice Mathevet Fabrice Lécuru on behalf of the SENTICOL Group Can Conization Specimens Predict Sentinel Lymph Node Status in Early-Stage Cervical Cancer? A SENTICOL Group Study Cancers cervical cancer sentinel lymph node conization SENTICOL stromal invasion lymphovascular space invasion |
| title | Can Conization Specimens Predict Sentinel Lymph Node Status in Early-Stage Cervical Cancer? A SENTICOL Group Study |
| title_full | Can Conization Specimens Predict Sentinel Lymph Node Status in Early-Stage Cervical Cancer? A SENTICOL Group Study |
| title_fullStr | Can Conization Specimens Predict Sentinel Lymph Node Status in Early-Stage Cervical Cancer? A SENTICOL Group Study |
| title_full_unstemmed | Can Conization Specimens Predict Sentinel Lymph Node Status in Early-Stage Cervical Cancer? A SENTICOL Group Study |
| title_short | Can Conization Specimens Predict Sentinel Lymph Node Status in Early-Stage Cervical Cancer? A SENTICOL Group Study |
| title_sort | can conization specimens predict sentinel lymph node status in early stage cervical cancer a senticol group study |
| topic | cervical cancer sentinel lymph node conization SENTICOL stromal invasion lymphovascular space invasion |
| url | https://www.mdpi.com/2072-6694/13/21/5423 |
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