Ultralow-intensity NIR light triggered on-demand drug release by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy
Junhui Shi,1 Zhengyan Zhao,2 Zongjun Liu,3 Ruozheng Wu,1 You Wang11School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, People’s Republic of China; 2State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, People&rsq...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-05-01
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| Series: | International Journal of Nanomedicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/ultralow-intensity-nir-light-triggered-on-demand-drug-release-by-emplo-peer-reviewed-article-IJN |
| _version_ | 1819008784635265024 |
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| author | Shi J Zhao Z Liu Z Wu R Wang Y |
| author_facet | Shi J Zhao Z Liu Z Wu R Wang Y |
| author_sort | Shi J |
| collection | DOAJ |
| description | Junhui Shi,1 Zhengyan Zhao,2 Zongjun Liu,3 Ruozheng Wu,1 You Wang11School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, People’s Republic of China; 2State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, People’s Republic of China; 3School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, People’s Republic of ChinaBackground: The design of novel nanoparticles with higher therapeutic efficacy and lower side effects, is still difficult but encouraging in cancer therapy. Specifically, for upconversion nanoparticles (UCNP)-based drug release, a high intensity of NIR light (1.4∼5.0 W/cm2,) above the maximum permissible exposure (0.33 W/cm2, for 980 nm) is commonly used and severely limits its practical application.Methods: The highly emissive UCNP is first synthesized and then coated with mesoporous silica (MS) shell (UCMS). Next, the surface of UCMS is modified with the thioether (-S-BP) linker, leading to UCMS-S-BP nanoparticles. Finally, after the drug doxorubicin (Dox) is loaded into the pore channels of UCMS, the pore openings are blocked by the β-cyclodextrin (β-CD) gatekeeper through the association with the -S-BP linker (UCMS(Dox)-S-BP@β-CD).Results: Upon 980 nm NIR light irradiation with an ultralow intensity of 0.30 W/cm,2 it is found that the loaded Dox can be released through the cleavage of thioether linkers triggering dissociation of β-CD gatekeepers. The in vitro results exhibited significantly therapeutic efficacy with 85.2% of HeLa cells killed in this study.Conclusions: An ultralow-intensity NIR light triggered on-demand drug release system has been developed by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy to avoid the potential photodamage on healthy neighbor cells.Keywords: drug release, ultralow intensity, density functional theory, near infrared light, upconversion nanoparticles |
| first_indexed | 2024-12-21T00:45:59Z |
| format | Article |
| id | doaj.art-e55e482b541b43008f0b3659d28b069f |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-21T00:45:59Z |
| publishDate | 2019-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-e55e482b541b43008f0b3659d28b069f2022-12-21T19:21:31ZengDove Medical PressInternational Journal of Nanomedicine1178-20132019-05-01Volume 144017402846185Ultralow-intensity NIR light triggered on-demand drug release by employing highly emissive UCNP and photocleavable linker with low bond dissociation energyShi JZhao ZLiu ZWu RWang YJunhui Shi,1 Zhengyan Zhao,2 Zongjun Liu,3 Ruozheng Wu,1 You Wang11School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, People’s Republic of China; 2State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, People’s Republic of China; 3School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, People’s Republic of ChinaBackground: The design of novel nanoparticles with higher therapeutic efficacy and lower side effects, is still difficult but encouraging in cancer therapy. Specifically, for upconversion nanoparticles (UCNP)-based drug release, a high intensity of NIR light (1.4∼5.0 W/cm2,) above the maximum permissible exposure (0.33 W/cm2, for 980 nm) is commonly used and severely limits its practical application.Methods: The highly emissive UCNP is first synthesized and then coated with mesoporous silica (MS) shell (UCMS). Next, the surface of UCMS is modified with the thioether (-S-BP) linker, leading to UCMS-S-BP nanoparticles. Finally, after the drug doxorubicin (Dox) is loaded into the pore channels of UCMS, the pore openings are blocked by the β-cyclodextrin (β-CD) gatekeeper through the association with the -S-BP linker (UCMS(Dox)-S-BP@β-CD).Results: Upon 980 nm NIR light irradiation with an ultralow intensity of 0.30 W/cm,2 it is found that the loaded Dox can be released through the cleavage of thioether linkers triggering dissociation of β-CD gatekeepers. The in vitro results exhibited significantly therapeutic efficacy with 85.2% of HeLa cells killed in this study.Conclusions: An ultralow-intensity NIR light triggered on-demand drug release system has been developed by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy to avoid the potential photodamage on healthy neighbor cells.Keywords: drug release, ultralow intensity, density functional theory, near infrared light, upconversion nanoparticleshttps://www.dovepress.com/ultralow-intensity-nir-light-triggered-on-demand-drug-release-by-emplo-peer-reviewed-article-IJNdrug releaseultralow intensitydensity functional theorynear infrared lightupconversion nanoparticles |
| spellingShingle | Shi J Zhao Z Liu Z Wu R Wang Y Ultralow-intensity NIR light triggered on-demand drug release by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy International Journal of Nanomedicine drug release ultralow intensity density functional theory near infrared light upconversion nanoparticles |
| title | Ultralow-intensity NIR light triggered on-demand drug release by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy |
| title_full | Ultralow-intensity NIR light triggered on-demand drug release by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy |
| title_fullStr | Ultralow-intensity NIR light triggered on-demand drug release by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy |
| title_full_unstemmed | Ultralow-intensity NIR light triggered on-demand drug release by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy |
| title_short | Ultralow-intensity NIR light triggered on-demand drug release by employing highly emissive UCNP and photocleavable linker with low bond dissociation energy |
| title_sort | ultralow intensity nir light triggered on demand drug release by employing highly emissive ucnp and photocleavable linker with low bond dissociation energy |
| topic | drug release ultralow intensity density functional theory near infrared light upconversion nanoparticles |
| url | https://www.dovepress.com/ultralow-intensity-nir-light-triggered-on-demand-drug-release-by-emplo-peer-reviewed-article-IJN |
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