Oxidative stress and Parkinson’s Disease
Parkinson disease is a chronic, progressive neurological disease that is associated with a loss of dopaminergic neurons in the substantia nigra of the brain. The molecular mechanisms underlying the loss of these neurons still remain elusive. Oxidative stress is thought to play an important role in d...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-07-01
|
| Series: | Frontiers in Neuroanatomy |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00091/full |
| _version_ | 1818967119667134464 |
|---|---|
| author | Javier eBlesa Javier eBlesa Javier eBlesa Ines eTrigo-Damas Ines eTrigo-Damas Anna eQuiroga-Varela Vernice Ruffin Jackson-Lewis |
| author_facet | Javier eBlesa Javier eBlesa Javier eBlesa Ines eTrigo-Damas Ines eTrigo-Damas Anna eQuiroga-Varela Vernice Ruffin Jackson-Lewis |
| author_sort | Javier eBlesa |
| collection | DOAJ |
| description | Parkinson disease is a chronic, progressive neurological disease that is associated with a loss of dopaminergic neurons in the substantia nigra of the brain. The molecular mechanisms underlying the loss of these neurons still remain elusive. Oxidative stress is thought to play an important role in dopaminergic neurotoxicity. Complex I deficiencies of the respiratory chain account for the majority of unfavorable neuronal degeneration in Parkinson’s Disease. Environmental factors, such as neurotoxins, insecticides like rotenone, pesticides like Paraquat, dopamine itself and genetic mutations in Parkinson’s Disease related proteins contribute to mitochondrial dysfunction which precedes reactive oxygen species formation. In this mini review, we give an update of the classical pathways involving these mechanisms of neurodegeneration, the biochemical and molecular events that mediate or regulate DA neuronal vulnerability, and the role of PD-related gene products in modulating cellular responses to oxidative stress in the course of the neurodegenerative process. |
| first_indexed | 2024-12-20T13:43:44Z |
| format | Article |
| id | doaj.art-e55fb90e52724cc797f923e3919bda40 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-12-20T13:43:44Z |
| publishDate | 2015-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-e55fb90e52724cc797f923e3919bda402022-12-21T19:38:45ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292015-07-01910.3389/fnana.2015.00091147963Oxidative stress and Parkinson’s DiseaseJavier eBlesa0Javier eBlesa1Javier eBlesa2Ines eTrigo-Damas3Ines eTrigo-Damas4Anna eQuiroga-Varela5Vernice Ruffin Jackson-Lewis6CINAC, HM Puerta del Sur, Hospitales de Madrid and Medical School, CEU-San Pablo UniversityCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)Columbia UniversityCINAC, HM Puerta del Sur, Hospitales de Madrid and Medical School, CEU-San Pablo UniversityCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)Clinica Neurologica, Università di Perugia, Ospedale S. Maria della MisericordiaColumbia UniversityParkinson disease is a chronic, progressive neurological disease that is associated with a loss of dopaminergic neurons in the substantia nigra of the brain. The molecular mechanisms underlying the loss of these neurons still remain elusive. Oxidative stress is thought to play an important role in dopaminergic neurotoxicity. Complex I deficiencies of the respiratory chain account for the majority of unfavorable neuronal degeneration in Parkinson’s Disease. Environmental factors, such as neurotoxins, insecticides like rotenone, pesticides like Paraquat, dopamine itself and genetic mutations in Parkinson’s Disease related proteins contribute to mitochondrial dysfunction which precedes reactive oxygen species formation. In this mini review, we give an update of the classical pathways involving these mechanisms of neurodegeneration, the biochemical and molecular events that mediate or regulate DA neuronal vulnerability, and the role of PD-related gene products in modulating cellular responses to oxidative stress in the course of the neurodegenerative process.http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00091/fullDopamineOxidative StressParkinson DiseaseMitochondrial dysfunctionNeuroinflammation |
| spellingShingle | Javier eBlesa Javier eBlesa Javier eBlesa Ines eTrigo-Damas Ines eTrigo-Damas Anna eQuiroga-Varela Vernice Ruffin Jackson-Lewis Oxidative stress and Parkinson’s Disease Frontiers in Neuroanatomy Dopamine Oxidative Stress Parkinson Disease Mitochondrial dysfunction Neuroinflammation |
| title | Oxidative stress and Parkinson’s Disease |
| title_full | Oxidative stress and Parkinson’s Disease |
| title_fullStr | Oxidative stress and Parkinson’s Disease |
| title_full_unstemmed | Oxidative stress and Parkinson’s Disease |
| title_short | Oxidative stress and Parkinson’s Disease |
| title_sort | oxidative stress and parkinson s disease |
| topic | Dopamine Oxidative Stress Parkinson Disease Mitochondrial dysfunction Neuroinflammation |
| url | http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00091/full |
| work_keys_str_mv | AT javiereblesa oxidativestressandparkinsonsdisease AT javiereblesa oxidativestressandparkinsonsdisease AT javiereblesa oxidativestressandparkinsonsdisease AT inesetrigodamas oxidativestressandparkinsonsdisease AT inesetrigodamas oxidativestressandparkinsonsdisease AT annaequirogavarela oxidativestressandparkinsonsdisease AT verniceruffinjacksonlewis oxidativestressandparkinsonsdisease |