Intestinal Barrier Permeability in Allergic Diseases
The role of intestinal permeability (IP) markers among children and adults with food allergies is not fully understood, and the identification of biological indicators/markers that predict growth retardation in children with allergic diseases and atopy has not been well explained. Studies have shown...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/9/1893 |
| _version_ | 1797503409035673600 |
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| author | Monika Niewiem Urszula Grzybowska-Chlebowczyk |
| author_facet | Monika Niewiem Urszula Grzybowska-Chlebowczyk |
| author_sort | Monika Niewiem |
| collection | DOAJ |
| description | The role of intestinal permeability (IP) markers among children and adults with food allergies is not fully understood, and the identification of biological indicators/markers that predict growth retardation in children with allergic diseases and atopy has not been well explained. Studies have shown that patients with atopic diseases respond abnormally to food allergens. Accordingly, differences in the types of immune complexes formed in response to antigen challenges are significant, which seems to underlie the systemic signs of the food allergy. Increased intestinal permeability over the course of a food allergy allows allergens to penetrate through the intestinal barrier and stimulate the submucosal immune system. Additionally, the release of cytokines and inflammatory mediators enhances the degradation of the epithelial barrier and leads to an improper cycle, resulting in increased intestinal permeability. Several studies have also demonstrated increased permeability of the epithelial cells in those afflicted with atopic eczema and bronchial asthma. Ongoing research is aimed at finding various indicators to assess IP in patients with atopic diseases. |
| first_indexed | 2024-03-10T03:50:12Z |
| format | Article |
| id | doaj.art-e560ab63641642828efc7e3ea5ab048e |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T03:50:12Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e560ab63641642828efc7e3ea5ab048e2023-11-23T08:59:54ZengMDPI AGNutrients2072-66432022-04-01149189310.3390/nu14091893Intestinal Barrier Permeability in Allergic DiseasesMonika Niewiem0Urszula Grzybowska-Chlebowczyk1Department of Pediatrics, Faculty of Medical Sciences, Medical University of Silesia in Katowice, 40-752 Katowice, PolandDepartment of Pediatrics, Faculty of Medical Sciences, Medical University of Silesia in Katowice, 40-752 Katowice, PolandThe role of intestinal permeability (IP) markers among children and adults with food allergies is not fully understood, and the identification of biological indicators/markers that predict growth retardation in children with allergic diseases and atopy has not been well explained. Studies have shown that patients with atopic diseases respond abnormally to food allergens. Accordingly, differences in the types of immune complexes formed in response to antigen challenges are significant, which seems to underlie the systemic signs of the food allergy. Increased intestinal permeability over the course of a food allergy allows allergens to penetrate through the intestinal barrier and stimulate the submucosal immune system. Additionally, the release of cytokines and inflammatory mediators enhances the degradation of the epithelial barrier and leads to an improper cycle, resulting in increased intestinal permeability. Several studies have also demonstrated increased permeability of the epithelial cells in those afflicted with atopic eczema and bronchial asthma. Ongoing research is aimed at finding various indicators to assess IP in patients with atopic diseases.https://www.mdpi.com/2072-6643/14/9/1893food allergychildrentight junctionsdysbiosismicrobiome |
| spellingShingle | Monika Niewiem Urszula Grzybowska-Chlebowczyk Intestinal Barrier Permeability in Allergic Diseases Nutrients food allergy children tight junctions dysbiosis microbiome |
| title | Intestinal Barrier Permeability in Allergic Diseases |
| title_full | Intestinal Barrier Permeability in Allergic Diseases |
| title_fullStr | Intestinal Barrier Permeability in Allergic Diseases |
| title_full_unstemmed | Intestinal Barrier Permeability in Allergic Diseases |
| title_short | Intestinal Barrier Permeability in Allergic Diseases |
| title_sort | intestinal barrier permeability in allergic diseases |
| topic | food allergy children tight junctions dysbiosis microbiome |
| url | https://www.mdpi.com/2072-6643/14/9/1893 |
| work_keys_str_mv | AT monikaniewiem intestinalbarrierpermeabilityinallergicdiseases AT urszulagrzybowskachlebowczyk intestinalbarrierpermeabilityinallergicdiseases |