Myomatrix arrays for high-definition muscle recording
Neurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding of motor control has grown rapidly thanks to new methods for recording and analyzing populations of many individual neurons over time. In contrast, current methods for recording the nerv...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2023-12-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/88551 |
| _version_ | 1827579286060531712 |
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| author | Bryce Chung Muneeb Zia Kyle A Thomas Jonathan A Michaels Amanda Jacob Andrea Pack Matthew J Williams Kailash Nagapudi Lay Heng Teng Eduardo Arrambide Logan Ouellette Nicole Oey Rhuna Gibbs Philip Anschutz Jiaao Lu Yu Wu Mehrdad Kashefi Tomomichi Oya Rhonda Kersten Alice C Mosberger Sean O'Connell Runming Wang Hugo Marques Ana Rita Mendes Constanze Lenschow Gayathri Kondakath Jeong Jun Kim William Olson Kiara N Quinn Pierce Perkins Graziana Gatto Ayesha Thanawalla Susan Coltman Taegyo Kim Trevor Smith Ben Binder-Markey Martin Zaback Christopher K Thompson Simon Giszter Abigail Person Martyn Goulding Eiman Azim Nitish Thakor Daniel O'Connor Barry Trimmer Susana Q Lima Megan R Carey Chethan Pandarinath Rui M Costa J Andrew Pruszynski Muhannad Bakir Samuel J Sober |
| author_facet | Bryce Chung Muneeb Zia Kyle A Thomas Jonathan A Michaels Amanda Jacob Andrea Pack Matthew J Williams Kailash Nagapudi Lay Heng Teng Eduardo Arrambide Logan Ouellette Nicole Oey Rhuna Gibbs Philip Anschutz Jiaao Lu Yu Wu Mehrdad Kashefi Tomomichi Oya Rhonda Kersten Alice C Mosberger Sean O'Connell Runming Wang Hugo Marques Ana Rita Mendes Constanze Lenschow Gayathri Kondakath Jeong Jun Kim William Olson Kiara N Quinn Pierce Perkins Graziana Gatto Ayesha Thanawalla Susan Coltman Taegyo Kim Trevor Smith Ben Binder-Markey Martin Zaback Christopher K Thompson Simon Giszter Abigail Person Martyn Goulding Eiman Azim Nitish Thakor Daniel O'Connor Barry Trimmer Susana Q Lima Megan R Carey Chethan Pandarinath Rui M Costa J Andrew Pruszynski Muhannad Bakir Samuel J Sober |
| author_sort | Bryce Chung |
| collection | DOAJ |
| description | Neurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding of motor control has grown rapidly thanks to new methods for recording and analyzing populations of many individual neurons over time. In contrast, current methods for recording the nervous system’s actual motor output – the activation of muscle fibers by motor neurons – typically cannot detect the individual electrical events produced by muscle fibers during natural behaviors and scale poorly across species and muscle groups. Here we present a novel class of electrode devices (‘Myomatrix arrays’) that record muscle activity at unprecedented resolution across muscles and behaviors. High-density, flexible electrode arrays allow for stable recordings from the muscle fibers activated by a single motor neuron, called a ‘motor unit,’ during natural behaviors in many species, including mice, rats, primates, songbirds, frogs, and insects. This technology therefore allows the nervous system’s motor output to be monitored in unprecedented detail during complex behaviors across species and muscle morphologies. We anticipate that this technology will allow rapid advances in understanding the neural control of behavior and identifying pathologies of the motor system. |
| first_indexed | 2024-03-08T21:59:36Z |
| format | Article |
| id | doaj.art-e563cae1ff0846e3ac2f96ce86dc95ca |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-03-08T21:59:36Z |
| publishDate | 2023-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-e563cae1ff0846e3ac2f96ce86dc95ca2023-12-19T15:59:34ZengeLife Sciences Publications LtdeLife2050-084X2023-12-011210.7554/eLife.88551Myomatrix arrays for high-definition muscle recordingBryce Chung0Muneeb Zia1Kyle A Thomas2Jonathan A Michaels3https://orcid.org/0000-0002-5179-3181Amanda Jacob4Andrea Pack5Matthew J Williams6Kailash Nagapudi7Lay Heng Teng8Eduardo Arrambide9Logan Ouellette10Nicole Oey11Rhuna Gibbs12Philip Anschutz13Jiaao Lu14https://orcid.org/0000-0002-7973-1679Yu Wu15Mehrdad Kashefi16https://orcid.org/0000-0001-5981-5923Tomomichi Oya17https://orcid.org/0000-0003-1233-6356Rhonda Kersten18Alice C Mosberger19https://orcid.org/0000-0003-1114-1469Sean O'Connell20Runming Wang21Hugo Marques22https://orcid.org/0000-0002-8709-4841Ana Rita Mendes23Constanze Lenschow24Gayathri Kondakath25Jeong Jun Kim26William Olson27Kiara N Quinn28Pierce Perkins29Graziana Gatto30https://orcid.org/0000-0002-4244-8925Ayesha Thanawalla31Susan Coltman32Taegyo Kim33Trevor Smith34Ben Binder-Markey35https://orcid.org/0000-0001-8920-4381Martin Zaback36Christopher K Thompson37Simon Giszter38Abigail Person39https://orcid.org/0000-0001-9805-7600Martyn Goulding40Eiman Azim41https://orcid.org/0000-0002-1015-1772Nitish Thakor42Daniel O'Connor43Barry Trimmer44Susana Q Lima45Megan R Carey46https://orcid.org/0000-0002-4499-1657Chethan Pandarinath47Rui M Costa48https://orcid.org/0000-0003-1707-1051J Andrew Pruszynski49https://orcid.org/0000-0003-0786-0081Muhannad Bakir50Samuel J Sober51https://orcid.org/0000-0002-1140-7469Department of Biology, Emory University, Atlanta, United StatesSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, United StatesGraduate Program in Biomedical Engineering at Emory University and Georgia Tech, Atlanta, United StatesDepartment of Physiology and Pharmacology, Western University, London, CanadaDepartment of Biology, Emory University, Atlanta, United StatesNeuroscience Graduate Program, Emory University, Atlanta, United StatesGraduate Program in Biomedical Engineering at Emory University and Georgia Tech, Atlanta, United StatesDepartment of Biology, Emory University, Atlanta, United StatesDepartment of Biology, Emory University, Atlanta, United StatesDepartment of Biology, Emory University, Atlanta, United StatesDepartment of Biology, Emory University, Atlanta, United StatesDepartment of Biology, Emory University, Atlanta, United StatesDepartment of Biology, Emory University, Atlanta, United StatesGraduate Program in BioEngineering, Georgia Tech, Atlanta, United StatesGraduate Program in Electrical and Computer Engineering, Georgia Tech, Atlanta, United StatesSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, United StatesDepartment of Physiology and Pharmacology, Western University, London, CanadaDepartment of Physiology and Pharmacology, Western University, London, CanadaDepartment of Physiology and Pharmacology, Western University, London, CanadaZuckerman Mind Brain Behavior Institute at Columbia University, New York, United StatesGraduate Program in Biomedical Engineering at Emory University and Georgia Tech, Atlanta, United StatesDepartment of Biomedical Engineering at Emory University and Georgia Tech, Atlanta, United StatesChampalimaud Neuroscience Programme, Champalimaud Foundation, Lisbon, PortugalChampalimaud Neuroscience Programme, Champalimaud Foundation, Lisbon, PortugalChampalimaud Neuroscience Programme, Champalimaud Foundation, Lisbon, PortugalDepartment of Biology, Tufts University, Medford, United StatesSolomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, United StatesSolomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, United StatesDepartments of Biomedical Engineering and Neurology, Johns Hopkins School of Medicine, Baltimore, United StatesDepartments of Biomedical Engineering and Neurology, Johns Hopkins School of Medicine, Baltimore, United StatesSalk Institute for Biological Studies, La Jolla, United StatesSalk Institute for Biological Studies, La Jolla, United StatesDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, United StatesDepartment of Neurobiology & Anatomy, Drexel University, College of Medicine, Philadelphia, United StatesDepartment of Neurobiology & Anatomy, Drexel University, College of Medicine, Philadelphia, United StatesDepartment of Physical Therapy and Rehabilitation Sciences, Drexel University College of Nursing and Health Professions, Philadelphia, United StatesDepartment of Health and Rehabilitation Sciences, Temple University, Philadelphia, United StatesDepartment of Health and Rehabilitation Sciences, Temple University, Philadelphia, United StatesDepartment of Neurobiology & Anatomy, Drexel University, College of Medicine, Philadelphia, United StatesDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, United States; Allen Institute, Seattle, United StatesSalk Institute for Biological Studies, La Jolla, United StatesSalk Institute for Biological Studies, La Jolla, United StatesDepartments of Biomedical Engineering and Neurology, Johns Hopkins School of Medicine, Baltimore, United StatesSolomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, United StatesDepartment of Biology, Tufts University, Medford, United StatesChampalimaud Neuroscience Programme, Champalimaud Foundation, Lisbon, PortugalChampalimaud Neuroscience Programme, Champalimaud Foundation, Lisbon, PortugalDepartment of Biomedical Engineering at Emory University and Georgia Tech, Atlanta, United StatesZuckerman Mind Brain Behavior Institute at Columbia University, New York, United StatesDepartment of Physiology and Pharmacology, Western University, London, CanadaSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, United StatesDepartment of Biology, Emory University, Atlanta, United StatesNeurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding of motor control has grown rapidly thanks to new methods for recording and analyzing populations of many individual neurons over time. In contrast, current methods for recording the nervous system’s actual motor output – the activation of muscle fibers by motor neurons – typically cannot detect the individual electrical events produced by muscle fibers during natural behaviors and scale poorly across species and muscle groups. Here we present a novel class of electrode devices (‘Myomatrix arrays’) that record muscle activity at unprecedented resolution across muscles and behaviors. High-density, flexible electrode arrays allow for stable recordings from the muscle fibers activated by a single motor neuron, called a ‘motor unit,’ during natural behaviors in many species, including mice, rats, primates, songbirds, frogs, and insects. This technology therefore allows the nervous system’s motor output to be monitored in unprecedented detail during complex behaviors across species and muscle morphologies. We anticipate that this technology will allow rapid advances in understanding the neural control of behavior and identifying pathologies of the motor system.https://elifesciences.org/articles/88551Bengalese finchfroghawk mothEMGelectrodemotor systems |
| spellingShingle | Bryce Chung Muneeb Zia Kyle A Thomas Jonathan A Michaels Amanda Jacob Andrea Pack Matthew J Williams Kailash Nagapudi Lay Heng Teng Eduardo Arrambide Logan Ouellette Nicole Oey Rhuna Gibbs Philip Anschutz Jiaao Lu Yu Wu Mehrdad Kashefi Tomomichi Oya Rhonda Kersten Alice C Mosberger Sean O'Connell Runming Wang Hugo Marques Ana Rita Mendes Constanze Lenschow Gayathri Kondakath Jeong Jun Kim William Olson Kiara N Quinn Pierce Perkins Graziana Gatto Ayesha Thanawalla Susan Coltman Taegyo Kim Trevor Smith Ben Binder-Markey Martin Zaback Christopher K Thompson Simon Giszter Abigail Person Martyn Goulding Eiman Azim Nitish Thakor Daniel O'Connor Barry Trimmer Susana Q Lima Megan R Carey Chethan Pandarinath Rui M Costa J Andrew Pruszynski Muhannad Bakir Samuel J Sober Myomatrix arrays for high-definition muscle recording eLife Bengalese finch frog hawk moth EMG electrode motor systems |
| title | Myomatrix arrays for high-definition muscle recording |
| title_full | Myomatrix arrays for high-definition muscle recording |
| title_fullStr | Myomatrix arrays for high-definition muscle recording |
| title_full_unstemmed | Myomatrix arrays for high-definition muscle recording |
| title_short | Myomatrix arrays for high-definition muscle recording |
| title_sort | myomatrix arrays for high definition muscle recording |
| topic | Bengalese finch frog hawk moth EMG electrode motor systems |
| url | https://elifesciences.org/articles/88551 |
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