β-Lactam Antibiotics—Drug-Drug Interaction Mediated by Organic Anion Transporters OAT1 and OAT3

β-Lactam Antibiotics—Drug-Drug Interaction Mediated by Organic Anion Transporters OAT1 and OAT3

Organic anion transporters OAT1 and OAT3 play a key role in elimination of most β-lactam antibiotics. Since nonsteroidal anti-inflammatory drugs, antivirals, antitumor agents, and some other drugs are also substrates of OAT1/3, this enables drug-drug interaction (DDI). The aim of the study was to an...

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Bibliographic Details
Main Authors:	I. A. Mazerkina, V. A. Evteev, A. B. Prokofiev, O. V. Muslimova, E. Yu. Demchenkova
Format:	Article
Language:	Russian
Published:	Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’) 2020-09-01
Series:	Регуляторные исследования и экспертиза лекарственных средств
Subjects:	organic anion transporters β-lactam antibiotics drug-drug interaction inhibition of organic anion transporters prediction of drug-drug interaction
Online Access:	https://www.vedomostincesmp.ru/jour/article/view/308

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