Use of Sensor Array Analysis to Detect Ovarian Cancer through Breath, Urine, and Blood: A Case-Control Study
Ovarian cancer (OC) is the eighth most common cancer in women. Since screening programs do not exist, it is often diagnosed in advanced stages. Today, the detection of OC is based on clinical examination, transvaginal ultrasound (US), and serum biomarker (Carbohydrate Antigen 125 (CA 125) and Human...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/14/5/561 |
| _version_ | 1797264678223609856 |
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| author | Roberto Angioli Marco Santonico Giorgio Pennazza Roberto Montera Daniela Luvero Alessandra Gatti Alessandro Zompanti Panaiotis Finamore Raffaele Antonelli Incalzi |
| author_facet | Roberto Angioli Marco Santonico Giorgio Pennazza Roberto Montera Daniela Luvero Alessandra Gatti Alessandro Zompanti Panaiotis Finamore Raffaele Antonelli Incalzi |
| author_sort | Roberto Angioli |
| collection | DOAJ |
| description | Ovarian cancer (OC) is the eighth most common cancer in women. Since screening programs do not exist, it is often diagnosed in advanced stages. Today, the detection of OC is based on clinical examination, transvaginal ultrasound (US), and serum biomarker (Carbohydrate Antigen 125 (CA 125) and Human Epididymis Protein 4 (HE4)) dosage, with a sensitivity of 88% and 95%, respectively, and a specificity of 84% for US and 76% for biomarkers. These methods are clearly not enough, and OC in its early stages is often missed. Many scientists have recently focused their attention on volatile organic compounds (VOCs). These are gaseous molecules, found in the breath, that could provide interesting information on several diseases, including solid tumors. To detect VOCs, an electronic nose was invented by a group of researchers. A similar device, the e-tongue, was later created to detect specific molecules in liquids. For the first time in the literature, we investigated the potential use of the electronic nose and the electronic tongue to detect ovarian cancer not just from breath but also from urine, blood, and plasma samples. |
| first_indexed | 2024-04-25T00:32:43Z |
| format | Article |
| id | doaj.art-e564e2e6908f456683e4fef924ec4d7e |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-04-25T00:32:43Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-e564e2e6908f456683e4fef924ec4d7e2024-03-12T16:42:11ZengMDPI AGDiagnostics2075-44182024-03-0114556110.3390/diagnostics14050561Use of Sensor Array Analysis to Detect Ovarian Cancer through Breath, Urine, and Blood: A Case-Control StudyRoberto Angioli0Marco Santonico1Giorgio Pennazza2Roberto Montera3Daniela Luvero4Alessandra Gatti5Alessandro Zompanti6Panaiotis Finamore7Raffaele Antonelli Incalzi8Unit of Gynecology, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 200, 00128 Rome, ItalyUnit of Electronics for Sensor Systems, Department of Science and Technology for Sustainable Development and One Health, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Rome, ItalyUnit of Electronics for Sensor Systems, Department of Engineering, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Rome, ItalyUnit of Gynecology, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 200, 00128 Rome, ItalyUnit of Gynecology, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 200, 00128 Rome, ItalyUnit of Gynecology, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 200, 00128 Rome, ItalyUnit of Electronics for Sensor Systems, Department of Engineering, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Rome, ItalyUnit of Geriatrics, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 200, 00128 Rome, ItalyUnit of Geriatrics, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 200, 00128 Rome, ItalyOvarian cancer (OC) is the eighth most common cancer in women. Since screening programs do not exist, it is often diagnosed in advanced stages. Today, the detection of OC is based on clinical examination, transvaginal ultrasound (US), and serum biomarker (Carbohydrate Antigen 125 (CA 125) and Human Epididymis Protein 4 (HE4)) dosage, with a sensitivity of 88% and 95%, respectively, and a specificity of 84% for US and 76% for biomarkers. These methods are clearly not enough, and OC in its early stages is often missed. Many scientists have recently focused their attention on volatile organic compounds (VOCs). These are gaseous molecules, found in the breath, that could provide interesting information on several diseases, including solid tumors. To detect VOCs, an electronic nose was invented by a group of researchers. A similar device, the e-tongue, was later created to detect specific molecules in liquids. For the first time in the literature, we investigated the potential use of the electronic nose and the electronic tongue to detect ovarian cancer not just from breath but also from urine, blood, and plasma samples.https://www.mdpi.com/2075-4418/14/5/561ovarian cancersensor arraycarbohydrate antigen 125human epididymis protein 4 |
| spellingShingle | Roberto Angioli Marco Santonico Giorgio Pennazza Roberto Montera Daniela Luvero Alessandra Gatti Alessandro Zompanti Panaiotis Finamore Raffaele Antonelli Incalzi Use of Sensor Array Analysis to Detect Ovarian Cancer through Breath, Urine, and Blood: A Case-Control Study Diagnostics ovarian cancer sensor array carbohydrate antigen 125 human epididymis protein 4 |
| title | Use of Sensor Array Analysis to Detect Ovarian Cancer through Breath, Urine, and Blood: A Case-Control Study |
| title_full | Use of Sensor Array Analysis to Detect Ovarian Cancer through Breath, Urine, and Blood: A Case-Control Study |
| title_fullStr | Use of Sensor Array Analysis to Detect Ovarian Cancer through Breath, Urine, and Blood: A Case-Control Study |
| title_full_unstemmed | Use of Sensor Array Analysis to Detect Ovarian Cancer through Breath, Urine, and Blood: A Case-Control Study |
| title_short | Use of Sensor Array Analysis to Detect Ovarian Cancer through Breath, Urine, and Blood: A Case-Control Study |
| title_sort | use of sensor array analysis to detect ovarian cancer through breath urine and blood a case control study |
| topic | ovarian cancer sensor array carbohydrate antigen 125 human epididymis protein 4 |
| url | https://www.mdpi.com/2075-4418/14/5/561 |
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