Assessment of water enema PET/CT: an effective imaging technique for the diagnosis of incidental colorectal 18F-FDG uptake
Abstract Background To validate the feasibility of water enema PET/CT (WE-PET/CT) in incidental colorectal 18F-FDG uptake and improve the accuracy of diagnosing colorectal neoplastic lesions. Methods We retrospectively analysed the electronic records of 338 patients undergoing common PET/CT and WE-P...
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| Format: | Article |
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BMC
2024-01-01
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| Series: | BMC Medical Imaging |
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| Online Access: | https://doi.org/10.1186/s12880-023-01186-0 |
| _version_ | 1797362815681429504 |
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| author | Rongqin Zhang Meilinuer Abudurexiti Wanglin Qiu Pinbo Huang Ping Hu Wei Fan Zhanwen Zhang |
| author_facet | Rongqin Zhang Meilinuer Abudurexiti Wanglin Qiu Pinbo Huang Ping Hu Wei Fan Zhanwen Zhang |
| author_sort | Rongqin Zhang |
| collection | DOAJ |
| description | Abstract Background To validate the feasibility of water enema PET/CT (WE-PET/CT) in incidental colorectal 18F-FDG uptake and improve the accuracy of diagnosing colorectal neoplastic lesions. Methods We retrospectively analysed the electronic records of 338 patients undergoing common PET/CT and WE-PET/CT at our hospital. PET/CT results were correlated with colonoscopy pathology and follow-up results. The ROC contrast curve was plotted to evaluate the accuracy of SUVmax on common PET/CT and WE-PET/CT for detecting neoplastic lesions. SUVmax and the median retention indexes (RIs) of cancerous, precancerous, and benign lesions and physiologic uptake were compared. Results The sensitivity, specificity and accuracy of diagnosing neoplastic lesions with common PET/CT were 84.0%, 78.3% and 80.2%, respectively. The corresponding results with WE-PET/CT were 95.8%, 96.5% and 96.2%. The AUC of SUVmax on WE-PET/CT was significantly higher than that on common PET/CT (0.935 vs. 0.524, p < 0.001). The median SUVmax on WE-PET/CT was significantly higher than that on common PET/CT in cancerous and precancerous lesions, and significantly decreased in benign lesions and physiologic uptake (p < 0.001). The RI was significantly different between cancerous lesions and physiologic uptake, between precancerous lesions and physiologic uptake, between benign lesions and physiologic uptake, and between cancerous and benign lesions (p < 0.05). Conclusions WE-PET/CT is a noninvasive, well-tolerated and effective technique for diagnosing incidental colorectal 18F-FDG uptake. It is helpful for a timely colonoscopy and can effectively avoid an unnecessary colonoscopy for incidental colorectal 18F-FDG uptake. |
| first_indexed | 2024-03-08T16:11:53Z |
| format | Article |
| id | doaj.art-e565155738e54f10b3eac4bd0ceed4d0 |
| institution | Directory Open Access Journal |
| issn | 1471-2342 |
| language | English |
| last_indexed | 2024-03-08T16:11:53Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj.art-e565155738e54f10b3eac4bd0ceed4d02024-01-07T12:54:25ZengBMCBMC Medical Imaging1471-23422024-01-0124111110.1186/s12880-023-01186-0Assessment of water enema PET/CT: an effective imaging technique for the diagnosis of incidental colorectal 18F-FDG uptakeRongqin Zhang0Meilinuer Abudurexiti1Wanglin Qiu2Pinbo Huang3Ping Hu4Wei Fan5Zhanwen Zhang6Department of Nuclear Medicine, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-Sen University Cancer CenterDepartment of Nuclear Medicine, The First People’s Hospital of Xinjiang Kashgar AreaDepartment of Nuclear Medicine and Molecular Imaging, The Sixth Affiliated Hospital, Sun Yat-sen UniversityDepartment of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityDepartment of Nuclear Medicine and Molecular Imaging, The Sixth Affiliated Hospital, Sun Yat-sen UniversityDepartment of Nuclear Medicine, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-Sen University Cancer CenterDepartment of Nuclear Medicine and Molecular Imaging, The Sixth Affiliated Hospital, Sun Yat-sen UniversityAbstract Background To validate the feasibility of water enema PET/CT (WE-PET/CT) in incidental colorectal 18F-FDG uptake and improve the accuracy of diagnosing colorectal neoplastic lesions. Methods We retrospectively analysed the electronic records of 338 patients undergoing common PET/CT and WE-PET/CT at our hospital. PET/CT results were correlated with colonoscopy pathology and follow-up results. The ROC contrast curve was plotted to evaluate the accuracy of SUVmax on common PET/CT and WE-PET/CT for detecting neoplastic lesions. SUVmax and the median retention indexes (RIs) of cancerous, precancerous, and benign lesions and physiologic uptake were compared. Results The sensitivity, specificity and accuracy of diagnosing neoplastic lesions with common PET/CT were 84.0%, 78.3% and 80.2%, respectively. The corresponding results with WE-PET/CT were 95.8%, 96.5% and 96.2%. The AUC of SUVmax on WE-PET/CT was significantly higher than that on common PET/CT (0.935 vs. 0.524, p < 0.001). The median SUVmax on WE-PET/CT was significantly higher than that on common PET/CT in cancerous and precancerous lesions, and significantly decreased in benign lesions and physiologic uptake (p < 0.001). The RI was significantly different between cancerous lesions and physiologic uptake, between precancerous lesions and physiologic uptake, between benign lesions and physiologic uptake, and between cancerous and benign lesions (p < 0.05). Conclusions WE-PET/CT is a noninvasive, well-tolerated and effective technique for diagnosing incidental colorectal 18F-FDG uptake. It is helpful for a timely colonoscopy and can effectively avoid an unnecessary colonoscopy for incidental colorectal 18F-FDG uptake.https://doi.org/10.1186/s12880-023-01186-0Incidental colorectal lesionsPositron emission tomographyColorectal 18F-FDG uptakeWater enema |
| spellingShingle | Rongqin Zhang Meilinuer Abudurexiti Wanglin Qiu Pinbo Huang Ping Hu Wei Fan Zhanwen Zhang Assessment of water enema PET/CT: an effective imaging technique for the diagnosis of incidental colorectal 18F-FDG uptake BMC Medical Imaging Incidental colorectal lesions Positron emission tomography Colorectal 18F-FDG uptake Water enema |
| title | Assessment of water enema PET/CT: an effective imaging technique for the diagnosis of incidental colorectal 18F-FDG uptake |
| title_full | Assessment of water enema PET/CT: an effective imaging technique for the diagnosis of incidental colorectal 18F-FDG uptake |
| title_fullStr | Assessment of water enema PET/CT: an effective imaging technique for the diagnosis of incidental colorectal 18F-FDG uptake |
| title_full_unstemmed | Assessment of water enema PET/CT: an effective imaging technique for the diagnosis of incidental colorectal 18F-FDG uptake |
| title_short | Assessment of water enema PET/CT: an effective imaging technique for the diagnosis of incidental colorectal 18F-FDG uptake |
| title_sort | assessment of water enema pet ct an effective imaging technique for the diagnosis of incidental colorectal 18f fdg uptake |
| topic | Incidental colorectal lesions Positron emission tomography Colorectal 18F-FDG uptake Water enema |
| url | https://doi.org/10.1186/s12880-023-01186-0 |
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