Links between Diet, Intestinal Anaerobes, Microbial Metabolites and Health
A dense microbial community resides in the human colon, with considerable inter-individual variability in composition, although some species are relatively dominant and widespread in healthy individuals. In disease conditions, there is often a reduction in microbial diversity and perturbations in th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/5/1338 |
| _version_ | 1797600962021425152 |
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| author | Sylvia H. Duncan Elena Conti Liviana Ricci Alan W. Walker |
| author_facet | Sylvia H. Duncan Elena Conti Liviana Ricci Alan W. Walker |
| author_sort | Sylvia H. Duncan |
| collection | DOAJ |
| description | A dense microbial community resides in the human colon, with considerable inter-individual variability in composition, although some species are relatively dominant and widespread in healthy individuals. In disease conditions, there is often a reduction in microbial diversity and perturbations in the composition of the microbiota. Dietary complex carbohydrates that reach the large intestine are important modulators of the composition of the microbiota and their primary metabolic outputs. Specialist gut bacteria may also transform plant phenolics to form a spectrum of products possessing antioxidant and anti-inflammatory activities. Consumption of diets high in animal protein and fat may lead to the formation of potentially deleterious microbial products, including nitroso compounds, hydrogen sulphide, and trimethylamine. Gut anaerobes also form a range of secondary metabolites, including polyketides that may possess antimicrobial activity and thus contribute to microbe–microbe interactions within the colon. The overall metabolic outputs of colonic microbes are derived from an intricate network of microbial metabolic pathways and interactions; however, much still needs to be learnt about the subtleties of these complex networks. In this review we consider the multi-faceted relationships between inter-individual microbiota variation, diet, and health. |
| first_indexed | 2024-03-11T03:55:13Z |
| format | Article |
| id | doaj.art-e56782f5905f40ee90b5bbdb4531e14a |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T03:55:13Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-e56782f5905f40ee90b5bbdb4531e14a2023-11-18T00:35:35ZengMDPI AGBiomedicines2227-90592023-05-01115133810.3390/biomedicines11051338Links between Diet, Intestinal Anaerobes, Microbial Metabolites and HealthSylvia H. Duncan0Elena Conti1Liviana Ricci2Alan W. Walker3Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UKRowett Institute, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UKRowett Institute, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UKRowett Institute, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UKA dense microbial community resides in the human colon, with considerable inter-individual variability in composition, although some species are relatively dominant and widespread in healthy individuals. In disease conditions, there is often a reduction in microbial diversity and perturbations in the composition of the microbiota. Dietary complex carbohydrates that reach the large intestine are important modulators of the composition of the microbiota and their primary metabolic outputs. Specialist gut bacteria may also transform plant phenolics to form a spectrum of products possessing antioxidant and anti-inflammatory activities. Consumption of diets high in animal protein and fat may lead to the formation of potentially deleterious microbial products, including nitroso compounds, hydrogen sulphide, and trimethylamine. Gut anaerobes also form a range of secondary metabolites, including polyketides that may possess antimicrobial activity and thus contribute to microbe–microbe interactions within the colon. The overall metabolic outputs of colonic microbes are derived from an intricate network of microbial metabolic pathways and interactions; however, much still needs to be learnt about the subtleties of these complex networks. In this review we consider the multi-faceted relationships between inter-individual microbiota variation, diet, and health.https://www.mdpi.com/2227-9059/11/5/1338microbial symbiosishost interactionsFirmicutesBacteroidetesdietary macro-nutrientsshort-chain fatty acids |
| spellingShingle | Sylvia H. Duncan Elena Conti Liviana Ricci Alan W. Walker Links between Diet, Intestinal Anaerobes, Microbial Metabolites and Health Biomedicines microbial symbiosis host interactions Firmicutes Bacteroidetes dietary macro-nutrients short-chain fatty acids |
| title | Links between Diet, Intestinal Anaerobes, Microbial Metabolites and Health |
| title_full | Links between Diet, Intestinal Anaerobes, Microbial Metabolites and Health |
| title_fullStr | Links between Diet, Intestinal Anaerobes, Microbial Metabolites and Health |
| title_full_unstemmed | Links between Diet, Intestinal Anaerobes, Microbial Metabolites and Health |
| title_short | Links between Diet, Intestinal Anaerobes, Microbial Metabolites and Health |
| title_sort | links between diet intestinal anaerobes microbial metabolites and health |
| topic | microbial symbiosis host interactions Firmicutes Bacteroidetes dietary macro-nutrients short-chain fatty acids |
| url | https://www.mdpi.com/2227-9059/11/5/1338 |
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