Comparison of acoustic radiation force impulse imaging (ARFI) to liver biopsy histologic scores in the evaluation of chronic liver disease: A pilot study
Background and aims. Acoustic Radiation Force Impulse Imaging (ARFI) is a novel non invasive technique studying the localized mechanical properties of tissue by utilising short, high intensity acoustic pulses (shear wave pulses) to assess the mechanical response (tissue displacement), providing a me...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2010-07-01
|
| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119316394 |
| _version_ | 1818602661833867264 |
|---|---|
| author | Maznar Haque Charlotte Robinson David Owen Eric M. Yoshida Alison Harris |
| author_facet | Maznar Haque Charlotte Robinson David Owen Eric M. Yoshida Alison Harris |
| author_sort | Maznar Haque |
| collection | DOAJ |
| description | Background and aims. Acoustic Radiation Force Impulse Imaging (ARFI) is a novel non invasive technique studying the localized mechanical properties of tissue by utilising short, high intensity acoustic pulses (shear wave pulses) to assess the mechanical response (tissue displacement), providing a measure of tissue elasticity. The aim of this study is to investigate the feasibility of ARFI imaging as a non-invasive method for the assessment of liver fibrosis compared to liver biopsy scores.Materials and methods. A prospective blind comparison study of ARFI elastography (Virtual Touch Imaging™, ACUSON S2000 Ultrasound Unit, Siemens, Mountain View CA) in a consecutive series of patients who underwent liver biopsy for assessment of fibrosis in chronic liver disease. ARFI shear-wave propagation velocity was measured in meters per second. Mean ARFI velocities were compared with both Batts-Ludwig (F0 to F4) and Modified Ishak scores (F0 to F4) for fibrosis in liver biopsy findings. Twenty-one patients with chronic liver disease (Hepatitis C (HCV) = 16, Hepatitis B (HBV) = 1, both HCV and HBV = 1 Alcoholic liver disease (ALD) = 1, others = 2) underwent ARFI and liver biopsy on the same day.Results. The Spearman correlation coefficients between the median values of the ARFI measurements and the histological fibrosis stage of the Modified Ishak score and Batts-Lud-≥ wig score were both highly significant (p < 0.01) with rho = 0.69 and rho = 0.72 respectively. The median ARFI (total 180 replications; minimum 5, maximum 10 measurements per patients) velocities for our study population range from 0.92 to 4.17 m/sec. Areas under the receiver operating characteristic curve for the accuracy of ARFI imaging was 1.00 and 0.35, for the diagnosis of moderate fibrosis (histologic fibrosis stage, F ≥ 2) and 0.85 and 0.85 respectively for Ishak and Batts-Ludwig score, for the diagnosis of cirrhosis.Conclusion. ARFI imaging has a strong correlation with the fibrosis stage of both Batts-Ludwig and shak score in chronic liver disease. It’s accuracy in prediction of severe fibrosis and cirrhosis is maximal in comparison with earlier stages. |
| first_indexed | 2024-12-16T13:10:50Z |
| format | Article |
| id | doaj.art-e569e7de1abe4d5a882884360847a3ce |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-16T13:10:50Z |
| publishDate | 2010-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-e569e7de1abe4d5a882884360847a3ce2022-12-21T22:30:38ZengElsevierAnnals of Hepatology1665-26812010-07-0193289293Comparison of acoustic radiation force impulse imaging (ARFI) to liver biopsy histologic scores in the evaluation of chronic liver disease: A pilot studyMaznar Haque0Charlotte Robinson1David Owen2Eric M. Yoshida3Alison Harris4Division of Gastroenterology. University of British Columbia and the Vancouver General Hospital, Canada.Departments of Radiology. University of British Columbia and the Vancouver General Hospital, Canada.Department of Pathology, University of British Columbia and the Vancouver General Hospital, Canada.Division of Gastroenterology. University of British Columbia and the Vancouver General Hospital, Canada.Departments of Radiology. University of British Columbia and the Vancouver General Hospital, Canada.; Correspondence and reprint request: Dr. Alison Harris, Vancouver General Hospital1. Department of Radiology, 899 W12th Avenue, Vancouver, BC, V5Z 1M9, Tel.: 604-875-4111 Fax: 604-875-4228Background and aims. Acoustic Radiation Force Impulse Imaging (ARFI) is a novel non invasive technique studying the localized mechanical properties of tissue by utilising short, high intensity acoustic pulses (shear wave pulses) to assess the mechanical response (tissue displacement), providing a measure of tissue elasticity. The aim of this study is to investigate the feasibility of ARFI imaging as a non-invasive method for the assessment of liver fibrosis compared to liver biopsy scores.Materials and methods. A prospective blind comparison study of ARFI elastography (Virtual Touch Imaging™, ACUSON S2000 Ultrasound Unit, Siemens, Mountain View CA) in a consecutive series of patients who underwent liver biopsy for assessment of fibrosis in chronic liver disease. ARFI shear-wave propagation velocity was measured in meters per second. Mean ARFI velocities were compared with both Batts-Ludwig (F0 to F4) and Modified Ishak scores (F0 to F4) for fibrosis in liver biopsy findings. Twenty-one patients with chronic liver disease (Hepatitis C (HCV) = 16, Hepatitis B (HBV) = 1, both HCV and HBV = 1 Alcoholic liver disease (ALD) = 1, others = 2) underwent ARFI and liver biopsy on the same day.Results. The Spearman correlation coefficients between the median values of the ARFI measurements and the histological fibrosis stage of the Modified Ishak score and Batts-Lud-≥ wig score were both highly significant (p < 0.01) with rho = 0.69 and rho = 0.72 respectively. The median ARFI (total 180 replications; minimum 5, maximum 10 measurements per patients) velocities for our study population range from 0.92 to 4.17 m/sec. Areas under the receiver operating characteristic curve for the accuracy of ARFI imaging was 1.00 and 0.35, for the diagnosis of moderate fibrosis (histologic fibrosis stage, F ≥ 2) and 0.85 and 0.85 respectively for Ishak and Batts-Ludwig score, for the diagnosis of cirrhosis.Conclusion. ARFI imaging has a strong correlation with the fibrosis stage of both Batts-Ludwig and shak score in chronic liver disease. It’s accuracy in prediction of severe fibrosis and cirrhosis is maximal in comparison with earlier stages.http://www.sciencedirect.com/science/article/pii/S1665268119316394Chronic Liver DiseaseLiver BiopsyNon-invasiveARFIAcoustic Radiation Force Impulse Imaging |
| spellingShingle | Maznar Haque Charlotte Robinson David Owen Eric M. Yoshida Alison Harris Comparison of acoustic radiation force impulse imaging (ARFI) to liver biopsy histologic scores in the evaluation of chronic liver disease: A pilot study Annals of Hepatology Chronic Liver Disease Liver Biopsy Non-invasive ARFI Acoustic Radiation Force Impulse Imaging |
| title | Comparison of acoustic radiation force impulse imaging (ARFI) to liver biopsy histologic scores in the evaluation of chronic liver disease: A pilot study |
| title_full | Comparison of acoustic radiation force impulse imaging (ARFI) to liver biopsy histologic scores in the evaluation of chronic liver disease: A pilot study |
| title_fullStr | Comparison of acoustic radiation force impulse imaging (ARFI) to liver biopsy histologic scores in the evaluation of chronic liver disease: A pilot study |
| title_full_unstemmed | Comparison of acoustic radiation force impulse imaging (ARFI) to liver biopsy histologic scores in the evaluation of chronic liver disease: A pilot study |
| title_short | Comparison of acoustic radiation force impulse imaging (ARFI) to liver biopsy histologic scores in the evaluation of chronic liver disease: A pilot study |
| title_sort | comparison of acoustic radiation force impulse imaging arfi to liver biopsy histologic scores in the evaluation of chronic liver disease a pilot study |
| topic | Chronic Liver Disease Liver Biopsy Non-invasive ARFI Acoustic Radiation Force Impulse Imaging |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119316394 |
| work_keys_str_mv | AT maznarhaque comparisonofacousticradiationforceimpulseimagingarfitoliverbiopsyhistologicscoresintheevaluationofchronicliverdiseaseapilotstudy AT charlotterobinson comparisonofacousticradiationforceimpulseimagingarfitoliverbiopsyhistologicscoresintheevaluationofchronicliverdiseaseapilotstudy AT davidowen comparisonofacousticradiationforceimpulseimagingarfitoliverbiopsyhistologicscoresintheevaluationofchronicliverdiseaseapilotstudy AT ericmyoshida comparisonofacousticradiationforceimpulseimagingarfitoliverbiopsyhistologicscoresintheevaluationofchronicliverdiseaseapilotstudy AT alisonharris comparisonofacousticradiationforceimpulseimagingarfitoliverbiopsyhistologicscoresintheevaluationofchronicliverdiseaseapilotstudy |