SCREENING OF PRE-DIABETES IN PATIENTS PRESENTING WITH POLYCYSTIC OVARIAN SYNDROME: A TERTIARY CARE EXPERIENCE
OBJECTIVE: To screen the females presenting with Polycystic Ovarian Syndrome (PCOS) for underlying pre-diabetes and to correlate pre-diabetes with the various diagnostic criteria of PCOS. METHODS: This descriptive cross-sectional study was conducted at Lady Reading Hospital Peshawar, Pakistan fro...
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| Format: | Article |
| Language: | English |
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Khyber Medical University
2021-12-01
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| Series: | Khyber Medical University Journal |
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| Online Access: | https://www.kmuj.kmu.edu.pk/article/view/21988 |
| _version_ | 1797807345495965696 |
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| author | Akhtar Hussain Sobia Sabir Ali Ibrar Ahmad Muhammad Nawaz Khan Syeda Hira Tahir |
| author_facet | Akhtar Hussain Sobia Sabir Ali Ibrar Ahmad Muhammad Nawaz Khan Syeda Hira Tahir |
| author_sort | Akhtar Hussain |
| collection | DOAJ |
| description | OBJECTIVE: To screen the females presenting with Polycystic Ovarian Syndrome (PCOS) for underlying pre-diabetes and to correlate pre-diabetes with the various diagnostic criteria of PCOS.
METHODS: This descriptive cross-sectional study was conducted at Lady Reading Hospital Peshawar, Pakistan from March, 2020 till December, 2020. One hundred & fifty one cases of PCOS, ranging in age from 17-40 years, were selected through purposive sampling. The Rotterdam criterion was used to diagnose PCOS, the details of history, physical examination and biochemical investigations like luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone, thyroid stimulating hormone (TSH), glycosylted hemoglobin (HBA1c), prolactin and pelvic ultrasound were recorded on a structured questionnaire.
RESULTS: Mean age of the patients was 23.42±4.88 years. Mean BMI was 33.27±26.98 kg/m2. Pre-diabetes was detected in 19.2% (n=29) and overt diabetes in 4.0% (n=6) of the women with PCOS. Hypertension, dyslipidemia and hypothyroidism were reported by 11 (7.2%), 9 (5.9%) and 4 (2.6%) patients respectively. Delayed menstrual cycle was reported by 44.8% (n=52); 27.6% (n=8) & 33.3% (n=2) cases of normoglycemic, prediabetes and diabetes mellitus respectively. Oligomenorrhoea was present in 69.0% (n=20) of pre-diabetics. Moderate and severe hirsutism was present in 44.8% and 10.3% PCOS patients with pre-diabetes. There was no significant correlation between pre-diabetes and the criteria of PCOS diagnosis.
CONCLUSION: Women with PCOS are at increased risk of pre-diabetes and other metabolic complications like obesity, hypertension and dyslipidemia at an earlier age. However, there was no significant correlation between pre-diabetes and the criteria of PCOS diagnosis. |
| first_indexed | 2024-03-13T06:21:10Z |
| format | Article |
| id | doaj.art-e56c638fb6a747c28c109dc9d9701e23 |
| institution | Directory Open Access Journal |
| issn | 2305-2643 2305-2651 |
| language | English |
| last_indexed | 2024-03-13T06:21:10Z |
| publishDate | 2021-12-01 |
| publisher | Khyber Medical University |
| record_format | Article |
| series | Khyber Medical University Journal |
| spelling | doaj.art-e56c638fb6a747c28c109dc9d9701e232023-06-09T19:18:39ZengKhyber Medical UniversityKhyber Medical University Journal2305-26432305-26512021-12-011342374310.35845/kmuj.2021.219881675SCREENING OF PRE-DIABETES IN PATIENTS PRESENTING WITH POLYCYSTIC OVARIAN SYNDROME: A TERTIARY CARE EXPERIENCEAkhtar Hussain0Sobia Sabir Ali1Ibrar Ahmad2Muhammad Nawaz Khan3Syeda Hira Tahir4Department of Diabetes & Endocrinology, MTI, Lady Reading Hospital, Peshawar, PakistanDepartment of Diabetes & Endocrinology, MTI, Lady Reading Hospital, Peshawar, PakistanDepartment of Diabetes & Endocrinology, MTI, Lady Reading Hospital, Peshawar, PakistanDepartment of Diabetes & Endocrinology, MTI, Lady Reading Hospital, Peshawar, PakistanDepartment of Diabetes & Endocrinology, MTI, Lady Reading Hospital, Peshawar, PakistanOBJECTIVE: To screen the females presenting with Polycystic Ovarian Syndrome (PCOS) for underlying pre-diabetes and to correlate pre-diabetes with the various diagnostic criteria of PCOS. METHODS: This descriptive cross-sectional study was conducted at Lady Reading Hospital Peshawar, Pakistan from March, 2020 till December, 2020. One hundred & fifty one cases of PCOS, ranging in age from 17-40 years, were selected through purposive sampling. The Rotterdam criterion was used to diagnose PCOS, the details of history, physical examination and biochemical investigations like luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone, thyroid stimulating hormone (TSH), glycosylted hemoglobin (HBA1c), prolactin and pelvic ultrasound were recorded on a structured questionnaire. RESULTS: Mean age of the patients was 23.42±4.88 years. Mean BMI was 33.27±26.98 kg/m2. Pre-diabetes was detected in 19.2% (n=29) and overt diabetes in 4.0% (n=6) of the women with PCOS. Hypertension, dyslipidemia and hypothyroidism were reported by 11 (7.2%), 9 (5.9%) and 4 (2.6%) patients respectively. Delayed menstrual cycle was reported by 44.8% (n=52); 27.6% (n=8) & 33.3% (n=2) cases of normoglycemic, prediabetes and diabetes mellitus respectively. Oligomenorrhoea was present in 69.0% (n=20) of pre-diabetics. Moderate and severe hirsutism was present in 44.8% and 10.3% PCOS patients with pre-diabetes. There was no significant correlation between pre-diabetes and the criteria of PCOS diagnosis. CONCLUSION: Women with PCOS are at increased risk of pre-diabetes and other metabolic complications like obesity, hypertension and dyslipidemia at an earlier age. However, there was no significant correlation between pre-diabetes and the criteria of PCOS diagnosis.https://www.kmuj.kmu.edu.pk/article/view/21988polycystic ovarian syndromepcosprediabetic stateprediabetesdiabetes mellitusdyslipidemiashypertensionmetabolic complicationsobesity |
| spellingShingle | Akhtar Hussain Sobia Sabir Ali Ibrar Ahmad Muhammad Nawaz Khan Syeda Hira Tahir SCREENING OF PRE-DIABETES IN PATIENTS PRESENTING WITH POLYCYSTIC OVARIAN SYNDROME: A TERTIARY CARE EXPERIENCE Khyber Medical University Journal polycystic ovarian syndrome pcos prediabetic state prediabetes diabetes mellitus dyslipidemias hypertension metabolic complications obesity |
| title | SCREENING OF PRE-DIABETES IN PATIENTS PRESENTING WITH POLYCYSTIC OVARIAN SYNDROME: A TERTIARY CARE EXPERIENCE |
| title_full | SCREENING OF PRE-DIABETES IN PATIENTS PRESENTING WITH POLYCYSTIC OVARIAN SYNDROME: A TERTIARY CARE EXPERIENCE |
| title_fullStr | SCREENING OF PRE-DIABETES IN PATIENTS PRESENTING WITH POLYCYSTIC OVARIAN SYNDROME: A TERTIARY CARE EXPERIENCE |
| title_full_unstemmed | SCREENING OF PRE-DIABETES IN PATIENTS PRESENTING WITH POLYCYSTIC OVARIAN SYNDROME: A TERTIARY CARE EXPERIENCE |
| title_short | SCREENING OF PRE-DIABETES IN PATIENTS PRESENTING WITH POLYCYSTIC OVARIAN SYNDROME: A TERTIARY CARE EXPERIENCE |
| title_sort | screening of pre diabetes in patients presenting with polycystic ovarian syndrome a tertiary care experience |
| topic | polycystic ovarian syndrome pcos prediabetic state prediabetes diabetes mellitus dyslipidemias hypertension metabolic complications obesity |
| url | https://www.kmuj.kmu.edu.pk/article/view/21988 |
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