A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary CaVβ subunits
Inhibiting high-voltage-activated calcium channels (HVACCs; CaV1/CaV2) is therapeutic for myriad cardiovascular and neurological diseases. For particular applications, genetically-encoded HVACC blockers may enable channel inhibition with greater tissue-specificity and versatility than is achievable...
Main Authors: | Travis J Morgenstern, Jinseo Park, Qing R Fan, Henry M Colecraft |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-08-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/49253 |
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