Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018 [version 2; peer review: 2 approved]
Background: Vancomycin is an antibiotic of growing importance in the treatment of hospital-acquired infections; with a particular emphasis on its value in the fight against Methicillin-resistant Staphylococcus aureus. Increasing reports of Vancomycin resistance have raised concerns about the effecti...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2021-11-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/8-1708/v2 |
| _version_ | 1818986992363372544 |
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| author | Tagwa A. M. Salih Bashir A. Yousef Mohamed A. M. Salih Khalid S. Eltom |
| author_facet | Tagwa A. M. Salih Bashir A. Yousef Mohamed A. M. Salih Khalid S. Eltom |
| author_sort | Tagwa A. M. Salih |
| collection | DOAJ |
| description | Background: Vancomycin is an antibiotic of growing importance in the treatment of hospital-acquired infections; with a particular emphasis on its value in the fight against Methicillin-resistant Staphylococcus aureus. Increasing reports of Vancomycin resistance have raised concerns about the effectiveness of this drug. Drug utilization evaluation has an important role in controlling rational use of antibiotics to prevent the emergence of resistance. Methods: We conducted a retrospective 6-months study at Jafar Ibn Auf pediatric hospital. Data including patient's demographics, diagnosis, Dosage regimen, and treatment duration were reviewed. The concordance of practice with the Hospital Infection Control Practices Advisory Committee (HICPAC) guidelines and principles of antibiotic therapy was assessed. Results: 127 medical records were reviewed in this study. Sepsis (29%) and Pneumonia (19.6%) were the most common indications. Culture test was requested in 20.5% of patients. Monitoring of serum creatinine was carried in 81.1% of patients. Based on HICPAC guidelines vancomycin was administered appropriately in 67.7% percent of cases. Considering the infusion rate, most of patients with specific order were received vancomycin in 1 hour. Conclusions: The results showed that vancomycin was used empirically without subsequent adjustment of the antimicrobial agent according to culture and sensitivity data and lack of paying enough attention to the infusion rate and serum creatinine monitoring. |
| first_indexed | 2024-12-20T18:59:36Z |
| format | Article |
| id | doaj.art-e56e8117127d43e6b015b7a58efe6d3f |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-20T18:59:36Z |
| publishDate | 2021-11-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-e56e8117127d43e6b015b7a58efe6d3f2022-12-21T19:29:26ZengF1000 Research LtdF1000Research2046-14022021-11-01810.12688/f1000research.19370.279346Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018 [version 2; peer review: 2 approved]Tagwa A. M. Salih0Bashir A. Yousef1Mohamed A. M. Salih2Khalid S. Eltom3Department of Pharmacology, Faculty of Pharmacy, Sudan International University, Khartoum, Khartoum, 11111, SudanDepartment of Pharmacology, Faculty of Pharmacy, University of Khartoum, Khartoum, Khartoum, 11111, SudanDepartment of Clinical chemistry, Faculty of Medical Laboratory, Karary University, Khartoum, Khartoum, 11111, SudanDepartment of Pediatrics, Faculty of Medicine, National Ribat University, Khartoum, Khartoum, 11111, SudanBackground: Vancomycin is an antibiotic of growing importance in the treatment of hospital-acquired infections; with a particular emphasis on its value in the fight against Methicillin-resistant Staphylococcus aureus. Increasing reports of Vancomycin resistance have raised concerns about the effectiveness of this drug. Drug utilization evaluation has an important role in controlling rational use of antibiotics to prevent the emergence of resistance. Methods: We conducted a retrospective 6-months study at Jafar Ibn Auf pediatric hospital. Data including patient's demographics, diagnosis, Dosage regimen, and treatment duration were reviewed. The concordance of practice with the Hospital Infection Control Practices Advisory Committee (HICPAC) guidelines and principles of antibiotic therapy was assessed. Results: 127 medical records were reviewed in this study. Sepsis (29%) and Pneumonia (19.6%) were the most common indications. Culture test was requested in 20.5% of patients. Monitoring of serum creatinine was carried in 81.1% of patients. Based on HICPAC guidelines vancomycin was administered appropriately in 67.7% percent of cases. Considering the infusion rate, most of patients with specific order were received vancomycin in 1 hour. Conclusions: The results showed that vancomycin was used empirically without subsequent adjustment of the antimicrobial agent according to culture and sensitivity data and lack of paying enough attention to the infusion rate and serum creatinine monitoring.https://f1000research.com/articles/8-1708/v2 |
| spellingShingle | Tagwa A. M. Salih Bashir A. Yousef Mohamed A. M. Salih Khalid S. Eltom Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018 [version 2; peer review: 2 approved] F1000Research |
| title | Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018 [version 2; peer review: 2 approved] |
| title_full | Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018 [version 2; peer review: 2 approved] |
| title_fullStr | Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018 [version 2; peer review: 2 approved] |
| title_full_unstemmed | Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018 [version 2; peer review: 2 approved] |
| title_short | Drug Utilization Evaluation of Vancomycin among Patients in Jafar Ibn Auf Pediatric Hospital, 2018 [version 2; peer review: 2 approved] |
| title_sort | drug utilization evaluation of vancomycin among patients in jafar ibn auf pediatric hospital 2018 version 2 peer review 2 approved |
| url | https://f1000research.com/articles/8-1708/v2 |
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