Preparation and in Vitro Evaluation for Different Types of Ondansetron Hydrochloride Transdermal Patches
This research aims to develop transdermal patches of Ondansetron hydrochloride (OSH) with different types of polymers, ethyl cellulose and, polyvinyl pyrrolidone k30 in a ratio (3:0.5,3:1,3:2,2:1,1:1) with propylene glycol 20%w/w as a plasticizer. Prepared transdermal patches were evaluated for phy...
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| Format: | Article |
| Language: | English |
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College of Pharmacy University of Baghdad
2023-06-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/1801 |
| _version_ | 1797802411574689792 |
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| author | Karima Abd allatif Jameela Ali Hasian |
| author_facet | Karima Abd allatif Jameela Ali Hasian |
| author_sort | Karima Abd allatif |
| collection | DOAJ |
| description |
This research aims to develop transdermal patches of Ondansetron hydrochloride (OSH) with different types of polymers, ethyl cellulose and, polyvinyl pyrrolidone k30 in a ratio (3:0.5,3:1,3:2,2:1,1:1) with propylene glycol 20%w/w as a plasticizer. Prepared transdermal patches were evaluated for physical properties. The compatibility between the drug and excipients was studied by Differential scanning calorimetry (DSC), where there is no interaction between the drug and polymers. From the statistical study, there is a statistical difference between all the prepared formulations p<0.05. In-vitro Release study of transdermal patches was performed by using a paddle over the disc. The release profile of OSH followed Korsmeyer - Peppas Model in P2, P4 formulations and, Higuchi Model in P1, P3, P5 formulations. The best formulation P6 carrying EC:PVP in ratio1:1 released 96.47% of ondansetron hydrochloride during 12 h. The release profile of P6 followed the Higuchi model and correlation coefficient (r2 = 0.9815)
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| first_indexed | 2024-03-13T05:05:18Z |
| format | Article |
| id | doaj.art-e56eead08a9e4c5a97dde0ccc47ec462 |
| institution | Directory Open Access Journal |
| issn | 2521-3512 1683-3597 |
| language | English |
| last_indexed | 2024-03-13T05:05:18Z |
| publishDate | 2023-06-01 |
| publisher | College of Pharmacy University of Baghdad |
| record_format | Article |
| series | Iraqi Journal of Pharmaceutical Sciences |
| spelling | doaj.art-e56eead08a9e4c5a97dde0ccc47ec4622023-06-16T19:53:56ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences2521-35121683-35972023-06-0132110.31351/vol32iss1pp147-155 Preparation and in Vitro Evaluation for Different Types of Ondansetron Hydrochloride Transdermal PatchesKarima Abd allatif0Jameela Ali Hasian1Department of Pharmaceutical Technology, Damascus University, Syria.Department of Pharmaceutics, Faculty of Pharmacy, Damascus University, Syria. This research aims to develop transdermal patches of Ondansetron hydrochloride (OSH) with different types of polymers, ethyl cellulose and, polyvinyl pyrrolidone k30 in a ratio (3:0.5,3:1,3:2,2:1,1:1) with propylene glycol 20%w/w as a plasticizer. Prepared transdermal patches were evaluated for physical properties. The compatibility between the drug and excipients was studied by Differential scanning calorimetry (DSC), where there is no interaction between the drug and polymers. From the statistical study, there is a statistical difference between all the prepared formulations p<0.05. In-vitro Release study of transdermal patches was performed by using a paddle over the disc. The release profile of OSH followed Korsmeyer - Peppas Model in P2, P4 formulations and, Higuchi Model in P1, P3, P5 formulations. The best formulation P6 carrying EC:PVP in ratio1:1 released 96.47% of ondansetron hydrochloride during 12 h. The release profile of P6 followed the Higuchi model and correlation coefficient (r2 = 0.9815) https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/1801Keywords: ondansetron hydrochloride, transdermal patches, ethyl cellulose, propylene glycol, polyvinyl pyrrolidone. |
| spellingShingle | Karima Abd allatif Jameela Ali Hasian Preparation and in Vitro Evaluation for Different Types of Ondansetron Hydrochloride Transdermal Patches Iraqi Journal of Pharmaceutical Sciences Keywords: ondansetron hydrochloride, transdermal patches, ethyl cellulose, propylene glycol, polyvinyl pyrrolidone. |
| title | Preparation and in Vitro Evaluation for Different Types of Ondansetron Hydrochloride Transdermal Patches |
| title_full | Preparation and in Vitro Evaluation for Different Types of Ondansetron Hydrochloride Transdermal Patches |
| title_fullStr | Preparation and in Vitro Evaluation for Different Types of Ondansetron Hydrochloride Transdermal Patches |
| title_full_unstemmed | Preparation and in Vitro Evaluation for Different Types of Ondansetron Hydrochloride Transdermal Patches |
| title_short | Preparation and in Vitro Evaluation for Different Types of Ondansetron Hydrochloride Transdermal Patches |
| title_sort | preparation and in vitro evaluation for different types of ondansetron hydrochloride transdermal patches |
| topic | Keywords: ondansetron hydrochloride, transdermal patches, ethyl cellulose, propylene glycol, polyvinyl pyrrolidone. |
| url | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/1801 |
| work_keys_str_mv | AT karimaabdallatif preparationandinvitroevaluationfordifferenttypesofondansetronhydrochloridetransdermalpatches AT jameelaalihasian preparationandinvitroevaluationfordifferenttypesofondansetronhydrochloridetransdermalpatches |